Open Science Datasets from PREVENT-AD, a Longitudinal Cohort of Pre-symptomatic Alzheimer’s Disease

Tremblay‐Mercier, Jennifer; Madjar, Cécile; Das, Samir; Binette, Alexa Pichet; Dyke, Stephanie O.M.; Étienne, Pierre; Lafaille‐Magnan, Marie‐Élyse; Remz, Jordana; Bellec, Pierre; Collins, D. Louis; Rajah, M. Natasha; Bohbot, Véronique D.; Leoutsakos, Jeannie‐Marie; Iturria-Medina, Yasser; Kat, Justin; Hoge, Richard D.; Gauthier, Serge; Tardif, Christine; Chakravarty, M. Mallar; Poline, Jean‐Baptiste; Rosa‐Neto, Pedro; Evans, Alan C.; Villeneuve, Sylvia; Poirier, Judes; Breitner, John C.S.

doi:10.1101/2020.03.04.976670

Cited by 8 publications

(5 citation statements)

References 59 publications

(57 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…APOE gene variant was determined using pyrosequencing with PyroMark Q96 (Qiagen, Toronto, ON, Canada). For further detail on the methods used in the PREVENT-AD cohort, see Tremblay-Mercier et al [40].…”

Section: Apoe Genotypingmentioning

confidence: 99%

APOE4 Status is Related to Differences in Memory-Related Brain Function in Asymptomatic Older Adults with Family History of Alzheimer’s Disease: Baseline Analysis of the PREVENT-AD Task Functional MRI Dataset

Rabipour

Rajagopal

et al. 2020

JAD

Self Cite

View full text Add to dashboard Cite

Background: Episodic memory decline is one of the earliest symptoms of late-onset Alzheimer's disease (AD). Older adults with the apolipoprotein E 4 (+APOE4) genetic risk factor for AD may exhibit altered patterns of memory-related brain activity years prior to initial symptom onset. Objective: Here we report the baseline episodic memory task functional MRI results from the PRe-symptomatic EValuation of Experimental or Novel Treatments for Alzheimer's Disease cohort in Montreal, Canada, in which 327 healthy older adults were scanned within 15 years of their parent's conversion to AD.

show abstract

Section: Apoe Genotypingmentioning

confidence: 99%

APOE4 Status is Related to Differences in Memory-Related Brain Function in Asymptomatic Older Adults with Family History of Alzheimer’s Disease: Baseline Analysis of the PREVENT-AD Task Functional MRI Dataset

Rabipour

Rajagopal

et al. 2020

JAD

Self Cite

View full text Add to dashboard Cite

show abstract

“…Over the last years, the AD field witnessed a fortunate shift to a more accessible and comprehensible data culture. New studies such as PREVENT-AD [ 24 ] and EPAD [ 25 ] recently joined the ranks of ADNI, DIAN [ 26 ], and others by making their data accessible to third party researchers. Currently running studies, for example the Deep Frequent Phenotype Study [ 27 ], already emphasized that the collected data will be published.…”

Section: Discussionmentioning

confidence: 99%

ANMerge: A Comprehensive and Accessible Alzheimer’s Disease Patient-Level Dataset

Birkenbihl

Westwood

Shi

et al. 2021

JAD

View full text Add to dashboard Cite

Background: Accessible datasets are of fundamental importance to the advancement of Alzheimer’s disease (AD) research. The AddNeuroMed consortium conducted a longitudinal observational cohort study with the aim to discover AD biomarkers. During this study, a broad selection of data modalities was measured including clinical assessments, magnetic resonance imaging, genotyping, transcriptomic profiling, and blood plasma proteomics. Some of the collected data were shared with third-party researchers. However, this data was incomplete, erroneous, and lacking in interoperability. Objective: To provide the research community with an accessible, multimodal, patient-level AD cohort dataset. Methods: We systematically addressed several limitations of the originally shared data and provided additional unreleased data to enhance the patient-level dataset. Results: In this work, we publish and describe ANMerge, a new version of the AddNeuroMed dataset. ANMerge includes multimodal data from 1,702 study participants and is accessible to the research community via a centralized portal. Conclusion: ANMerge is an information rich patient-level data resource that can serve as a discovery and validation cohort for data-driven AD research, such as, for example, machine learning and artificial intelligence approaches.

show abstract

“…All procedures were approved by the McGill University Faculty of Medicine Institutional Review Board. All research complied with ethical principles of the Declaration of Helsinki [46,50].…”

Section: Prevent-admentioning

confidence: 99%

MSR1 and NEP Are Correlated with Alzheimer’s Disease Amyloid Pathology and Apolipoprotein Alterations

Miron

Picard

Labonté

et al. 2022

JAD

View full text Add to dashboard Cite

Background: In mouse models of amyloidosis, macrophage receptor 1 (MSR1) and neprilysin (NEP) have been shown to interact to reduce amyloid burden in the brain. Objective: The purpose of this study is to analyze these two gene products in combination with apolipoproteins and Aβ 1 - 42 in the cerebrospinal fluid (CSF) and plasma of individuals at different stages of Alzheimer’s disease (AD), as well as in autopsied brain samples from ROSMAP (Religious Orders Study and Memory and Aging Project). Methods: CSF/plasma levels of MSR1 and NEP were measured using the sensitive primer extension assay technology. CSF Aβ 1 - 42 was assessed with ELISA, while CSF ApoE and ApoJ were measured with the Luminex’s multiplex technology. Brain MSR1, APOE, and CLU (ApoJ) mRNA levels were measured with RNA-Seq and contrasted to amyloid plaques pathology using CERAD staging. Results: While plasma and CSF MSR1 levels are significantly correlated, this correlation was not observed for NEP. In addition to be highly correlated to one another, CSF levels of both MSR1 and NEP are strongly correlated with AD status and CSF Aβ 1 - 42, ApoE, and ApoJ levels. In the cortical tissues of subjects from ROSMAP, MSR1 mRNA levels are correlated with CLU mRNA levels and the CERAD scores but not with APOE mRNA levels. Conclusion: The discrepancies observed between CSF/plasma levels of MSR1 and NEP with CSF Aβ 1 - 42 and ApoE concentrations can be explained by many factors, such as the disease stage or the involvement of the blood-brain barrier breakdown that leads to the infiltration of peripheral monocytes or macrophages.

show abstract

Open Science Datasets from PREVENT-AD, a Longitudinal Cohort of Pre-symptomatic Alzheimer’s Disease

Cited by 8 publications

References 59 publications

APOE4 Status is Related to Differences in Memory-Related Brain Function in Asymptomatic Older Adults with Family History of Alzheimer’s Disease: Baseline Analysis of the PREVENT-AD Task Functional MRI Dataset

APOE4 Status is Related to Differences in Memory-Related Brain Function in Asymptomatic Older Adults with Family History of Alzheimer’s Disease: Baseline Analysis of the PREVENT-AD Task Functional MRI Dataset

ANMerge: A Comprehensive and Accessible Alzheimer’s Disease Patient-Level Dataset

MSR1 and NEP Are Correlated with Alzheimer’s Disease Amyloid Pathology and Apolipoprotein Alterations

Contact Info

Product

Resources

About