Open-tubular Electrochromatographic Chiral Separation of Amino Acids Using an Organic Nanocrystals Immobilized Capillary

Kitagawa, Fumihiko; Sudaki, Hiroshi; Sueyoshi, Kenji; Otsuka, Koji

doi:10.2116/analsci.29.107

Cited by 10 publications

(8 citation statements)

References 28 publications

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“…Up to 14 peaks for glycoisoforms of ovalbumin were observed using borate buffer (40 mM, pH 9.0) and a capillary coated with ZrO 2 nanoparticles . Cinchonidine nanocrystals also appear to show promise for the field of OT‐CEC .…”

Section: Improvement Of Ce Separationmentioning

confidence: 99%

CE and nanomaterials – Part II: Nanomaterials in CE

Adam

Vaculovičová

2017

Electrophoresis

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The scope of this two-part review is to summarize publications dealing with CE and nanomaterials together. This topic can be viewed from two broad perspectives, and this article is trying to highlight these two approaches: (i) CE of nanomaterials, and (ii) nanomaterials in CE. The second part aims at summarization of publications dealing with application of nanomaterials for enhancement of CE performance either in terms of increasing the separation resolution or for improvement of the detection. To increase the resolution, nanomaterials are employed as either surface modification of the capillary wall forming open tubular column or as additives to the separation electrolyte resulting in a pseudostationary phase. Moreover, nanomaterials have proven to be very beneficial for increasing also the sensitivity of detection employed in CE or even they enable the detection (e.g., fluorescent tags of nonfluorescent molecules).

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Section: Improvement Of Ce Separationmentioning

confidence: 99%

CE and nanomaterials – Part II: Nanomaterials in CE

Adam

Vaculovičová

2017

Electrophoresis

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“…Kitagawa et al. embedded cinchonidine nanocrystals onto the cationic PDDA via electrostatic LbL deposition . Qu and coworkers have fabricated an octadecyltrichlorosilane (C 18 )‐derivatized silica nanoparticle‐based coating using a “multilayer‐by‐multilayer” deposition approach .…”

Section: Preparation Approaches For Ot‐cec Coatingsmentioning

confidence: 99%

“…Separations in OT‐CEC are dictated inter alia by the electrophoretic mobility of the analytes, the magnitude of the EOF and the chromatographic affinity of the analytes for the coating on the inner capillary wall. The types of interaction encountered may be hydrophobic , aromatic as manifested via the classically known π–π stacking , hydrophilic (dipole–dipole and hydrogen bonding) , and ionic interactions . These interactions are responsible for the reversed‐phase, ion‐exchange, hydrophilic interaction, mixed mode, and chiral characteristics of these separations, as indicated in Table , third column.…”

Section: Modes Of Separationmentioning

confidence: 99%

“…Other reported chiral selectors have included the well‐known cinchona alkaloids , vancomycin glycopeptide , l ‐histidine and copper(II) ligand exchanger , dopamine , and BSA . Polysaccharide‐based chiral SPs have also found application.…”

Section: Modes Of Separationmentioning

confidence: 99%

“…Biomolecules and natural compounds ranging from simple sugars , amino acids [, peptides , nucleosides , phenolics , flavonoids , and aroma compounds to high molecular weight macromolecules like proteins have also been investigated. The CEC separation of proteins and/or peptides has been highlighted in a number of earlier reviews , the most recent of which was in 2009.…”

Section: Applicationsmentioning

confidence: 99%

See 2 more Smart Citations

Open tubular‐capillary electrochromatography: Developments and applications from 2013 to 2015

et al. 2016

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Open tubular CEC (OT-CEC) separates analyte mixtures by a combination of electrophoretic, electro-osmotic, and/or chromatographic effects. OT-CEC research is an active and growing field, with studies encompassing a wide range of investigations related to new strategies for chemical modification of the inner surface of the capillary, leading to the introduction of novel stationary phase coatings. This review has examined the literature on OT-CEC from 2013 to August 2015 and highlights the developments in the fabrication of highly selective stationary phases, based on materials that include cyclodextrin chiral selectors, graphene and graphene oxide, metal-organic frameworks, molecularly imprinted polymers, nanoparticles, nanolatex particles, nanocomposites, in situ generated polymers, block polymers, tentacle-type polymers, polyelectrolyte multilayers, polysaccharides, phospholipids, and proteins. This review, while considering the development of novel OT-CEC coating materials, specifically examines different immobilization or coating methodologies and approaches and also discusses the separation mechanisms that occur with these new materials. These OT-CEC coatings are intended mainly to separate low molecular weight molecules relevant to the pharmaceutical, agricultural, and food industries as well as for use in environmental monitoring.

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Organic/Hybrid Nanoparticles and Single‐Walled Carbon Nanotubes: Preparation Methods and Chiral Applications

et al. 2014

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Nanoparticles are molecular-sized solids with at least one dimension measuring between 1-100 nm or 10-1000 nm depending on the individual discipline's perspective. They are aggregates of anywhere from a few hundreds to tens of thousands of atoms which render them larger than molecules but smaller than bulk solids. Consequently, they frequently exhibit physical and chemical properties somewhere between. On the other hand, nanocrystals are a special class of nanoparticles which have started gaining attention recently owing to their unique crystalline structures which provide a larger surface area and promising applications including chiral separations. Hybrid nanoparticles are supported by the growing interest of chemists, physicists, and biologists, who are researching to fully exploit them. These materials can be defined as molecular or nano-composites with mixed (organic or bio) and inorganic components, where at least one of the component domain has a dimension ranging from a few Å to several nanometers. Similarly, and due to their extraordinary physical, chemical, and electrical properties, single-walled carbon nanotubes have been the subject of intense research. In this short review, the focus is mainly on the current well-established simple preparation techniques of chiral organic and hybrid nanoparticles as well as single-walled carbon nanotubes and their applications in separation science. Of particular interest, cinchonidine, chitosan, and β-CD-modified gold nanoparticles (GNPs) are discussed as model examples for organic and hybrid nanoparticles. Likewise, the chemical vapor deposition method, used in the preparation of single-walled carbon nanotubes, is discussed. The enantioseparation applications of these model nanomaterials is also presented.

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Open-tubular Electrochromatographic Chiral Separation of Amino Acids Using an Organic Nanocrystals Immobilized Capillary

Cited by 10 publications

References 28 publications

CE and nanomaterials – Part II: Nanomaterials in CE

CE and nanomaterials – Part II: Nanomaterials in CE

Open tubular‐capillary electrochromatography: Developments and applications from 2013 to 2015

Organic/Hybrid Nanoparticles and Single‐Walled Carbon Nanotubes: Preparation Methods and Chiral Applications

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