Operative Blood Loss, Blood Transfusion, and 30-Day Mortality in Older Patients After Major Noncardiac Surgery

Wu, Wen‐Chih; Smith, Tracy; Henderson, William G.; Eaton, Charles B.; Poses, Roy M.; Uttley, Georgette; Mor, Vincent; Sharma, Satish C.; Vezeridis, Michael P.; Khuri, Shukri F.; Friedmann, Peter D.

doi:10.1097/sla.0b013e3181e3e43f

Cited by 196 publications

(137 citation statements)

References 30 publications

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“…This would significantly reduce perioperative complications and the length of hospitalization. So, perioperative alogenous blood transfusion administration that is by itself linked to numerous complications would be thus reduced (26,27). Due to the limitations of our study, further prospective study in larger sample of patients is necessary.…”

Section: Discussionmentioning

confidence: 99%

Transurethral Resection of the Prostate and Pre-Operative Anemia, in Men Older Than 60 Years

Nestorov¹,

Gvozdenović²,

Šarkanović³

et al. 2016

ARC Journal of Anesthesiology

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Section: Discussionmentioning

confidence: 99%

Transurethral Resection of the Prostate and Pre-Operative Anemia, in Men Older Than 60 Years

Nestorov¹,

Gvozdenović²,

Šarkanović³

et al. 2016

ARC Journal of Anesthesiology

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“…16 Despite these issues, transfusion of red blood cells is still regarded as lifesaving in the setting of severe acute blood loss. 42 The risk of transfusion of red blood cells…”

Section: Current Trends In Red Blood Cell Transfusionmentioning

confidence: 99%

“…16 Malgré ces inquiétudes, la transfusion d'érythrocytes est encore considérée comme une mesure qui sauve des vies dans le contexte d'une perte de sang aiguë grave. 42 …”

Section: L'objectif Des Transfusions D'érythrocytesunclassified

Assessment and treatment of preoperative anemia: Continuing Professional Development

Hare

Baker

Pavenski

2011

Can J Anesth/J Can Anesth

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“…Perioperative EBL included intraoperative EBL, visual estimation and documentation by the anesthesiologist, and postoperative drain output. The formula by Wu et al [14,15] built from the National Surgical Quality Improvement Program data regarding surgical blood loss (EBL in milliliters = [31.265 * preoperative hematocrit] -[29.83 * postoperative hematocrit] + [269.67 * units of red blood cells transfused]) was used to confirm the accuracy of EBL (p = 0.503; 95% CI, À128.6 to 63.40), Preoperative autologous blood donation was offered to all patients and varied from zero to two units depending on patient preferences. Clinical records from routine followups were available for all patients and checked for incidence of DVT or PE.…”

Section: Methodsmentioning

confidence: 99%

Does Tranexamic Acid Reduce Blood Loss and Transfusion Requirements Associated With the Periacetabular Osteotomy?

Wingerter

Keith

Schoenecker

et al. 2015

Clinical Orthopaedics &Amp; Related Research

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Background Tranexamic acid (TXA) has shown safety and efficacy in reducing blood loss associated with various surgical procedures. However, to our knowledge there are no studies evaluating the effect of TXA on blood loss and transfusion requirements associated with periacetabular osteotomy (PAO). Questions/purposes The main purpose of this study is to determine whether TXA reduces blood loss and transfusion use in patients undergoing PAO for symptomatic acetabular dysplasia. Our secondary purpose was to compare the frequency of symptomatic thromboembolic events between patients undergoing surgery with and without TXA. Methods A consecutive series of 100 periacetabular osteotomies performed by one surgeon was reviewed to compare the groups immediately before and after implementation of routine use of tranexamic acid (two retrospective cohorts). TXA dosing followed an established protocol with a standard dose of 1 g infused intravenously during 10 minutes before skin incision and an additional 1 g intravenously at wound closure. Outcome measures include total estimated blood loss perioperatively and transfusion requirements. Total estimated blood loss was calculated using a formula built from the National Surgical Quality Improvement Program data regarding surgical blood loss. Results The mean perioperative total estimated blood loss was less in the patients receiving TXA compared with blood loss in patients who did not receive TXA (706 mL versus 1021 mL; p \ 0.001; 95% CI, À495 to À134). Twenty-six (52%) of the 50 patients who did not receive TXA had postoperative blood transfusions compared with 15 (30%) of 50 who received TXA (odds ratio, 0.395; 95% CI, p = 0.0414). No symptomatic deep vein thromboses or symptomatic pulmonary emboli were identified in either group. Conclusions TXA reduces estimated blood loss and the frequency of transfusions in patients undergoing PAO for treatment of symptomatic acetabular dysplasia. Future prospective studies should confirm our findings to determine whether patients undergoing PAO should receive routine perioperative TXA. Level of Evidence Level III, therapeutic study.

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Operative Blood Loss, Blood Transfusion, and 30-Day Mortality in Older Patients After Major Noncardiac Surgery

Cited by 196 publications

References 30 publications

Transurethral Resection of the Prostate and Pre-Operative Anemia, in Men Older Than 60 Years

Transurethral Resection of the Prostate and Pre-Operative Anemia, in Men Older Than 60 Years

Assessment and treatment of preoperative anemia: Continuing Professional Development

Does Tranexamic Acid Reduce Blood Loss and Transfusion Requirements Associated With the Periacetabular Osteotomy?

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