Opiate Action on Sleep and Breathing

Lydic, Ralph; Keifer, John C.; Baghdoyan, Helen A.; Craft, Robert M.; Angel, Chelsea

doi:10.1016/b978-0-323-24288-2.00024-6

Cited by 2 publications

(3 citation statements)

References 137 publications

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“…The evidence in this review demonstrates the feasibility of combining targeted and untargeted metabolomics to identify candidate molecules that modulate visceral functions of the prefrontal cortex. The discoveries reviewed here are consistent with evidence that the prefrontal cortex contributes to regulation of behavioral states (9,12,20,150,151) and breathing (7,24,59,65,76,143,152,153).…”

Section: Conclusion Tensions and Future Directionssupporting

confidence: 84%

“…As schematized, (FIGURE 1B, LEFT) these studies used dialysis delivery of morphine directly into the prefrontal cortex of C57BL/6J (B6) mice (24,71). Measures were made of eight neurotransmitters (FIGURE 2, A--H) shown previously to modulate breathing and sleep (13,14,18,(72)(73)(74)(75)(76)(77). Morphine administration caused a significant increase in the concentration of acetylcholine (FIGURE 2A) and a significant decrease in the concentration of adenosine (FIGURE 2D).…”

Section: Prefrontal Cortex Opioids Alter Neurochemistry and Breathingmentioning

confidence: 99%

“…For many years these traits were mistakenly interpreted as signs of sleep. Clinical and preclinical studies using polysomnography have shown that opioids inhibit sleep and disrupt the normal periodicity of the sleep-wake cycle (18,76,82,83) Misinterpreting opioid-induced blunting of wakefulness as sleep has been facilitated by the fact that opioids cause a dose-dependent dissociated state that comprises a mixture of traits that do not normally occur together (cf. FIGURE 3, A AND B).…”

Section: Prefrontal Cortex Opioids Alter Neurochemistry and Breathingmentioning

confidence: 99%

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Prefrontal Cortex Metabolome Is Modified by Opioids, Anesthesia, and Sleep

Lydic

Baghdoyan

2021

Physiology

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Obtundation of wakefulness caused by opioids and loss of wakefulness caused by anesthetics and sleep significantly alter concentrations of molecules comprising the prefrontal cortex (PFC) metabolome. Quantifying state-selective changes in the PFC metabolome is essential for advancing functional metabolomics. Diverse functions of the PFC suggest the PFC metabolome as a potential therapeutic entry point for countermeasures to state-selective autonomic dysfunction.

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Section: Conclusion Tensions and Future Directionssupporting

confidence: 84%

Section: Prefrontal Cortex Opioids Alter Neurochemistry and Breathingmentioning

confidence: 99%

Section: Prefrontal Cortex Opioids Alter Neurochemistry and Breathingmentioning

confidence: 99%

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Prefrontal Cortex Metabolome Is Modified by Opioids, Anesthesia, and Sleep

Lydic

Baghdoyan

2021

Physiology

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Opioids cause dissociated states of consciousness in C57BL/6J mice

O’Brien

Locklear

Glovak

et al. 2021

Journal of Neurophysiology

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The electroencephalogram (EEG) provides an objective, neural correlate of consciousness. Opioid receptors modulate mammalian neuronal excitability, and this fact was used to characterize how opioids administered to mice alter EEG power and states of consciousness. The present study tested the hypothesis that antinociceptive doses of fentanyl, morphine, or buprenorphine differentially alter the EEG and states of sleep and wakefulness in adult, male C57BL/6J mice. Mice were anesthetized and implanted with telemeters that enabled wireless recordings of cortical EEG and electromyogram (EMG). After surgical recovery, EEG and EMG were used to objectively score states of consciousness as wakefulness, rapid eye movement (REM) sleep, or non-REM (NREM) sleep. Measures of EEG power (dB) were quantified as delta (0.5 to 4 Hz), theta (4 to 8 Hz), alpha (8 to 13 Hz), sigma (12 to 15 Hz), beta (13 to 30 Hz), and gamma (30 to 60 Hz). Compared to saline (control), fentanyl and morphine decreased NREM sleep, morphine eliminated REM sleep, and buprenorphine eliminated NREM sleep and REM sleep. Opioids significantly and differentially disrupted the temporal organization of sleep/wake states, altered specific EEG frequency bands, and caused dissociated states of consciousness. The results are discussed relative to the fact that opioids, pain, and sleep modulate interacting states of consciousness.

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Opiate Action on Sleep and Breathing

Cited by 2 publications

References 137 publications

Prefrontal Cortex Metabolome Is Modified by Opioids, Anesthesia, and Sleep

Prefrontal Cortex Metabolome Is Modified by Opioids, Anesthesia, and Sleep

Opioids cause dissociated states of consciousness in C57BL/6J mice

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