Opioid‐Induced Alterations of TLR4 Protein Expression in a Human Microglial Cell Line

.Inhibitory effects of dynorphin 3-14 on the lipopolysaccharide-induced toll-like receptor 4 signalling pathway.Peptides http://dx.doi.org/10.1016/j.peptides. 2017.02.004 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.  DYN 3-14 inhibits NF-κB/p65 activation in response to LPS stimulation. DYN 3-14 differentially modulates the release of IL-1β and TNF-α induced by LPS. DYN 3-14 inhibits LPS-induced TLR4 signalling in a competitive manner. The endogenous opioids DYN 3-14 is a potential TLR4 antagonist.

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Inhibitory effects of dynorphin 3-14 on the lipopolysaccharide-induced toll-like receptor 4 signalling pathway

Rahiman

Morgan

Gray

et al. 2017

Peptides

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Opioid‐Induced Alterations of TLR4 Protein Expression in a Human Microglial Cell Line

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Inhibitory effects of dynorphin 3-14 on the lipopolysaccharide-induced toll-like receptor 4 signalling pathway

Inhibitory effects of dynorphin 3-14 on the lipopolysaccharide-induced toll-like receptor 4 signalling pathway

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