Opioidergic mechanisms mediating aggressive behavior in the cat

Shaikh, Majid B.; Dalsass, Mario; Siegel, Allan

doi:10.1002/1098-2337(1990)16:3/4<191::aid-ab2480160306>3.0.co;2-7

Cited by 20 publications

(5 citation statements)

References 65 publications

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“…A series of studies indicates that opiate agonists are likely to be effective in controlling aggressive behavior in opiate-addicted patients, as confirmed by the fall in levels of aggressiveness which follows adequate methadone treatment [ 51 , 52 ]. Moreover, aggressive symptoms are among the features that may be found in the habit of applying a self-medication theory [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Do methadone and buprenorphine have the same impact on psychopathological symptoms of heroin addicts?

et al. 2011

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BackgroundThe idea that the impact of opioid agonist treatment is influenced by the psychopathological profile of heroin addicts has not yet been investigated, and is based on the concept of a specific therapeutic action displayed by opioid agents on psychopathological symptoms. In the present report we compared the effects of buprenorphine and methadone on the psychopathological symptoms of 213 patients (106 on buprenorphine and 107 on methadone) in a follow-up study lasting 12 months.MethodsDrug addiction history was collected by means of the Drug Addiction History Rating Scale (DAH-RS) and psychopathological features were collected by means of the Symptom Checklist-90 (SCL-90), using a special five-factor solution. Toxicological urinalyses were carried out for each patient during the treatment period.ResultsNo statistically significant differences were detected in psychopathological symptoms, including 'worthlessness-being trapped', 'somatization', and 'panic-anxiety'. Methadone proved to be more effective on patients characterized by 'sensitivity-psychoticism', whereas buprenorphine was more effective on patients displaying a 'violence-suicide' symptomatology.ConclusionsHeroin-dependent patients with psychiatric comorbidities may benefit from opioid agonist treatment not only because it targets their addictive problem, but also, precisely due to this, because it is effective against their mental disorder too.

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Section: Discussionmentioning

confidence: 99%

Do methadone and buprenorphine have the same impact on psychopathological symptoms of heroin addicts?

et al. 2011

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“…Haney and Miczek [1989], using female mice, observed that during the first week of lactation morphine showed a trend to reduce attack behaviour toward female intruders. Shaikh et al [1990] found that in the cat, opioid peptides suppress affective defense behaviour elicited with electrode stimulation of the midbrain periaqueductal gray.…”

Section: Introductionmentioning

confidence: 99%

Effects of morphine hydrochloride on social encounters between male mice

Espert¹,

Navarro

Salvador³

et al. 1993

Aggr. Behav.

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The effects of a single injection of morphine hydrochloride (0.3, 0.6, or 1.25 mg/kg) or physiological saline (0.9% NaCI) on the agonistic behaviour elicited by isolation in male mice were examined. Individually housed mice were exposed to anosmic “standard opponents” 30 minutes after drug administration, and the encounters were videotaped and evaluated using an ethologically based analysis. Morphine (at 0.6 and 1.25 mg/kg) significantly and dose‐dependently decreased time spent in offensive (“threat” and “attack”) and “digging” behaviours but markedly increased “non‐social exploration” without a significant increase of “immobility.” The lowest dose was completely ineffective in producing changes in any of the behaviours studied. It is concluded that these results present a specific ethopharmacological profile characterized by suppression of aggressive behaviour, increase in non‐social explotation, and no evident impairment of motor activity. © 1993 Wiley‐Liss, Inc.

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“…The assessment of the role of opioids in modulating aggressive behavior is no easy matter, as most studies on the subject deal with animal models, where acts of aggression result in defensive behavior against preying. In the literature a variety of evidence allows the following conclusions to be reached [139,140,141,142,143,144].…”

Section: Treatment Of Violence During Methadone Maintenance Treatmentmentioning

confidence: 99%

“…The measured effects depended on time and dosage. In the same model, preying behaviors showed that cats had acquired a more extended period of latency after naloxone administration [141].…”

Section: Treatment Of Violence During Methadone Maintenance Treatmentmentioning

confidence: 99%

What we have learned from the Methadone Maintenance Treatment of Dual Disorder Heroin Use Disorder patients

Maremmani¹,

Pacini²,

Maremmani

2019

IJERPH

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Mental Disorders and Heroin Use Disorder (HUD) often co-occur and constitute correlated risk factors that the authors believe are best considered from a unitary perspective. In this article we review and discuss data collected by the V.P. Dole Research Group in Dual Disorder (V.P. Dole DD-RG) patients according to the following six discussion points: (1) Treatment of personality disorders during Methadone Maintenance Treatment (MMT); (2) Treatment of Mood Disorders during MMT; (3) Treatment of Anxiety Disorders during MMT; (4) Treatment of Psychotic Disorders during MMT; (5) Treatment of violence during MMT; (6) Treatment of Alcohol Use Disorder (AUD) during MMT. In treating Mood Disorder in HUD patients, we must bear in mind the interactions (potentiation and side effects) between psychopharmacology, used substances and agonist opioid medications; the use of psychiatric medications as an anti-craving drug, and the possible use of agonist and antagonist opioid medications in treating the other mental disorders. In treating chronic psychosis in HUD patients, we must consider the potentiation and side effects of antipsychotic drugs consequent on HUD treatment, worsening addiction hypophoria and inducing a more severe reward deficiency syndrome (RDS) in hypophoric patients. Violence and AUD during MMT can benefit from adequate dosages of methadone and co-medication with Sodium gamma-hydroxybutyrate (GHB). The experience of our V.P. Dole DD-RG suggests the following: (a) DD is the new paradigm in neuroscience in deepening our understanding of mental health; (b) To successfully treat DD patients a double competence is needed; (c) In managing DD patients priority must be given to Substance Use Disorder (SUD) treatment (stabilizing patients); (d) Antidepressant use is ancillary to SUD treatment; antipsychotic use must be restricted to acute phases; mood stabilizers must be preferred; any use of Benzodiazepines (BDZs) must be avoided.

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Opioidergic mechanisms mediating aggressive behavior in the cat

Cited by 20 publications

References 65 publications

Do methadone and buprenorphine have the same impact on psychopathological symptoms of heroin addicts?

Do methadone and buprenorphine have the same impact on psychopathological symptoms of heroin addicts?

Effects of morphine hydrochloride on social encounters between male mice

What we have learned from the Methadone Maintenance Treatment of Dual Disorder Heroin Use Disorder patients

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