Opioids and Down’s syndrome

Mafrica, Federica; Fodale, Vincenzo

doi:10.5055/jom.2006.0015

Cited by 12 publications

(11 citation statements)

References 43 publications

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“…More research is already shedding light on the mechanisms of glioma cell migration and invasion. Intersectin1 (ITNS1; also called EHSH1, Dap160, or ESE‐1) is a highly conserved protein during evolution and possesses multiple domains (Mafrica and Fodale,2006). It has two isoforms: the long isoform (ITSN1‐l) and the short isoform (ITSN1‐s).…”

mentioning

confidence: 99%

Intersectin1‐s is involved in migration and invasion of human glioma cells

Wang

et al. 2011

J of Neuroscience Research

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Malignant gliomas have a tendency to invade diffusely into surrounding healthy brain tissues, thereby precluding their successful surgical removal. Intersectin1 (ITSN1) as a molecular linker in the central nervous system is well known as an important regulator of endocytosis and exocytosis. ITSN1 has two isoforms: ITSN1-l and ITSN1-s. In this study, we show that siRNA-mediated down regulation of ITSN1-s inhibited migration and invasion of glioma cells. In addition, we demonstrate the possible mechanisms by which ITSN1-s functions in migration and invasion. Several key proteins, including cofilin, LIMK, PAK, FAK, integrin β1, and MMP-9, which are critical for cells migration and invasion, were probably involved in ITSN1-s signaling pathways. These results suggest that ITSN1-s contributes to glioma cells migration and invasion by regulating the formation of cytoskeleton, influencing adhesion and increasing expression of MMP-9. Our results indicate that ITSN1-s is a critical factor in gliomas invasion and identify that ITSN1-s is a new potentially antiinvasion target for therapeutic intervention in gliomas.

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confidence: 99%

Intersectin1‐s is involved in migration and invasion of human glioma cells

Wang

et al. 2011

J of Neuroscience Research

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“…Of the 16 articles included, five did not match our preset outcomes, although having been selected according to keywords and inclusion criteria. Four were narrative reviews (Mafrica & Fodale, 2006; Mafrica et al, 2006; McGuire & Kennedy, 2013; Symons et al, 2008) and one was a brief report (Doody & Bailey, 2019). They are nevertheless briefly summarized below.…”

Section: Resultsmentioning

confidence: 99%

“…Mafrica and Fodale (2006) published a topical review on opioids and Down syndrome, discussing in depth opioid pharmacokinetics and pharmacodynamics within the perspective of potential alteration in opioid pathways in the target population. Clues on perioperative opioid dosing and adverse effects are given on the basis of case reports (Mafrica & Fodale, 2006).…”

Section: Resultsmentioning

confidence: 99%

“…However, this topic deserves special attention, since adults with ID are frequently suffering for various somatic and psychiatric co‐morbidities, often leading to polymedication, risk of drug–drug interactions and adverse effects. Moreover, pharmacodynamic properties of analgesics may be modified in adults with ID, as most of these drugs have a central mechanism of action (Mafrica & Fodale, 2006; Mafrica, Schifilliti, & Fodale, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Pain interventions in adults with intellectual disability: A scoping review and pharmacological considerations

Lonchampt

Gerber²,

Aubry³

et al. 2020

European Journal of Pain

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Background and Objective Having to deal on a daily routine with prescriptions in adults with intellectual disability (ID), we systematically reviewed the literature on the specificities of pain interventions in that population, focusing on medication and trying to gather practical information on appropriate pain treatments. Given the scarcity of the literature on the topic, we also discussed the pharmacological considerations to be taken into account when prescribing analgesic drugs in that vulnerable population. Databases and Data Treatment Articles on pain and ID were searched in the Medline and Google scholar electronic databases using the key words "Intellectual Disability," "Developmental Disability" and specific keywords for pharmacological and non‐pharmacological pain interventions. Preset outcomes about pharmacological treatment specificity, efficacy and safety were then collected. Results One hundred and fifty‐two articles were found and 16 were retained based on our inclusion and exclusion criteria. Of the 16 articles, five were topical reviews. Among the 11 remaining articles, five discussed pharmacological interventions, four considered non‐pharmacological interventions and two discussed both. As anticipated, the literature matching our specific outcomes about the pharmacological treatment of pain was scarce and for the most part not designed to answer the questions of specificity, efficacy and safety of pain treatment in adults with ID. Conclusion The specificity of analgesic treatments in adults with ID is a totally unexplored domain. In the absence of clinical guidelines, pharmacological facts—such as inter‐individual variability in drug response, pharmacokinetic and pharmacodynamic interactions, frequent co‐morbidities and ease of administration—must be systematically integrated, when prescribing in the population of adults with ID. Significance This review synthesizes the state of research on pain interventions in adults with ID and is one of the rare articles addressing the specificities of analgesic prescriptions in this population.

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“…Some syndromes associated with learning difficulties may have increased sensitivity to opioids e.g. Down syndrome (79).…”

Section: Management Of Anesthesia For Children With Learning Disabilitymentioning

confidence: 99%