Opipramol dihydrochloride

Abstract

The title compound (systematic name: 4-{3-[2-aza­tricyclo­[9.4.0.03,8]penta­deca-1(15),3,5,7,11,13-hexaen-2-yl]prop­yl}-1-(2-hy­droxy­eth­yl)piperazine-1,4-diium dichloride), C23H31N3O+·2Cl−, is the dihydro­chloride of a piperazine derivative bearing a bulky 3-(5H-dibenz[b,f]azepin-5-yl)propyl substituent. Protonation took place on both N atoms of the piperazine unit. The diaza­cyclo­hexane ring adopts a chair conformation. N—H⋯Cl, O—H⋯Cl and C—H⋯Cl hydrogen bonding as well as C—H⋯O contacts connect the components into a three-dimensional network in the crystal. Two C—H⋯π contacts are also observed.

The crystal structure of 4-hydroxybenzene-1,3-diaminium dichloride, C6H10Cl2N2O

“…Furthermore, the benefit of choosing the adequate size of counterions to crystallize ionic compounds has been confirmed on many occasions [12]. In continuation of our interest in metrical features of large cations [13][14][15] the title structure has been determined. Furthermore, the molecular and crystal structure of metaphenylene diamine has been determined earlier [16].…”

The crystal structure of methacholine chloride, C8H18ClNO2

“…Furthermore, the benefit of chosing the adequate size of counterions to crystallize ionic compounds has been confirmed on many occasions [12]. In continuation of our interest in metrical features of large cations [13][14][15] the structure of the title compound has been determined. Methacholine chloride is a synthetic derivative of acetylcholine, a neurotransmitter.…”

The crystal structure of 4-chloro-1-methylpiperidin-1-ium chloride, C6H13Cl2N

“…Furthermore, the benefit of choosing the adequate size of counterions to crystallize ionic compounds has been confirmed on many occasions [12]. In continuation of our interest in metrical features of large cations [13][14][15] the structure of the title compound has been determined. A comparable molecular connectivity pattern has been characterized structurally previously in form of the chloride [16] and perchlorate [17] salts of 4-chloro quinuclidinium.…”