Opossum alcohol dehydrogenases: Sequences, structures, phylogeny and evolution

Holmes, Roger S.

doi:10.1016/j.cbi.2008.09.009

Cited by 6 publications

(1 citation statement)

References 48 publications

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“…According to recent studies, the human ALDH gene superfamily comprises 19 genes encoding enzymes critical for NAD (P) + —dependent oxidation of endogenous and exogenous aldehydes [120]. Meanwhile, there are at least seven genes in the ADH family [121]. ADH2 , ADH3 , and ALDH2 are thought to be the pivotal genetic determinants in ethanol metabolism and alcoholism in humans.…”

Section: Mechanisms Of Alcoholic Diseasesmentioning

confidence: 99%

Alcohol and Acetaldehyde in Public Health: From Marvel to Menace

Guo

Ren

2010

IJERPH

136

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Alcohol abuse is a serious medical and social problem. Although light to moderate alcohol consumption is beneficial to cardiovascular health, heavy drinking often results in organ damage and social problems. In addition, genetic susceptibility to the effect of alcohol on cancer and coronary heart disease differs across the population. A number of mechanisms including direct the toxicity of ethanol, its metabolites [e.g., acetaldehyde and fatty acid ethyl esters (FAEEs)] and oxidative stress may mediate alcoholic complications. Acetaldehyde, the primary metabolic product of ethanol, is an important candidate toxin in developing alcoholic diseases. Meanwhile, free radicals produced during ethanol metabolism and FAEEs are also important triggers for alcoholic damages.

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Section: Mechanisms Of Alcoholic Diseasesmentioning

confidence: 99%

Alcohol and Acetaldehyde in Public Health: From Marvel to Menace

Guo

Ren

2010

IJERPH

136

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Duplicated Gene Evolution of the Primate Alcohol Dehydrogenase Family

Oota

Kídd

2011

Post-Genome Biology of Primates

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Opossum Aldehyde Dehydrogenases: Evidence for Four ALDH1A1-like Genes on Chromosome 6 and ALDH1A2 and ALDH1A3 Genes on Chromosome 1

Holmes

2009

Biochem Genet

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Evidence is presented for six opossum ALDH1A genes, including four ALDH1A1-like genes on chromosome 6 and ALDH1A2- and ALDH1A3-like genes on chromosome 1. Predicted structures for the opossum aldehyde dehydrogenase (ALDH) subunits and the intron-exon boundaries for opossum ALDH genes showed a high degree of similarity with other mammalian ALDHs. Phylogenetic analyses supported the proposed designation of these opossum class 1 ALDHs as ALDH1A-like, ALDH1A2-like, and ALDH1A3-like and are therefore likely to play important roles in retinal and peroxidic aldehyde metabolism. Alignments of predicted opossum ALDH1A amino acid sequences with sheep ALDH1A1 and rat ALDH1A2 sequences demonstrated conservation of key residues previously shown to participate in catalysis and coenzyme binding. Amino acid substitution rates observed for family 1A ALDHs during vertebrate evolution indicated that ALDH1A2-like genes are evolving slower than ALDH1A1- and ALDH1A3-like genes. It is proposed that the common ancestor for ALDH1A genes predates the appearance of birds during vertebrate evolution.

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Opossum alcohol dehydrogenases: Sequences, structures, phylogeny and evolution

Cited by 6 publications

References 48 publications

Alcohol and Acetaldehyde in Public Health: From Marvel to Menace

Alcohol and Acetaldehyde in Public Health: From Marvel to Menace

Duplicated Gene Evolution of the Primate Alcohol Dehydrogenase Family

Opossum Aldehyde Dehydrogenases: Evidence for Four ALDH1A1-like Genes on Chromosome 6 and ALDH1A2 and ALDH1A3 Genes on Chromosome 1

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