Opportunistic Computed Tomography Screening Shows a High Incidence of Osteoporosis in Ankylosing Spondylitis Patients With Acute Vertebral Fractures

Emohare, Osa; Cagan, Amanda; Polly, David W.; Gertner, Elie

doi:10.1016/j.jocd.2014.07.006

Cited by 20 publications

(8 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Instead of areal BMD measured by DXA, QCT enables differentiation of spongiosa from cortical bone with a high imaging quality, and thereby improves volumetric BMD assessment in the presence of syndesmophytes at different degrees of osteoporosis . Various studies have found QCT may provide a more accurate BMD estimation in advanced AS patients than that of DXA for the spine or the hip…”

Section: Recommendationsmentioning

confidence: 99%

Clinical practice recommendations for the use of imaging in the diagnosis and management of axial spondyloarthritis in Taiwan

et al. 2019

View full text Add to dashboard Cite

Objective: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease bearing challenges in early diagnosis. To improve clinical diagnosis and management of axSpA, recommendations were developed with current axSpA classification criteria and recent advances in medical imaging applications. Methods: A systematic literature review was conducted by 10 rheumatologists and radiologists in Taiwan to retrieve research evidence on the utilization of imaging modalities, including conventional radiography (CR), magnetic resonance imaging (MRI), computed tomography (CT), ultrasound (US), quantitative sacroiliac scintigraphy (QSS), and dual-energy X-ray absorptiometry (DXA). The panel of experts proposed six key issues on the role of imaging in early diagnosis of axSpA, monitoring of disease activity and structural changes, predicting treatment effects, and assessing complications such as osteoporosis and spinal fracture. The consensus was established on the basis of research evidence, clinical experiences and expert opinions. For each | 25 WEI Et al.

show abstract

Section: Recommendationsmentioning

confidence: 99%

Clinical practice recommendations for the use of imaging in the diagnosis and management of axial spondyloarthritis in Taiwan

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Other studies have highlighted the possibility of underdiagnosis of osteoporosis among the AS population [14, 15]. In addition, few studies have explored the incidence of osteoporosis among AS patients, and those that have, are relatively small-scale (504 cases [16] and 17 cases [17]).…”

Section: Introductionmentioning

confidence: 99%

Should clinicians pay more attention to the potential underdiagnosis of osteoporosis in patients with ankylosing spondylitis? A national population-based study in Taiwan

Hu¹,

Lu²,

Chen³

et al. 2019

PLoS ONE

View full text Add to dashboard Cite

ObjectivesThere are limited studies describing the association between ankylosing spondylitis (AS) and osteoporosis. We conducted a nationwide retrospective cohort study to investigate this epidemiologic evidence.MethodsData were obtained from the Taiwan National Health Insurance Research Database (NHIRD). Of 10,290 participants, 2,058 patients with AS and 8,232 patients without AS were enrolled from the NHIRD between 2000 to 2013. Cumulative incidences of osteoporosis were compared between 2 groups. Cox regression model was used to estimate the hazard ratio (HR) of developing osteoporosis after controlling for demographic and other co-morbidities, and subgroup analyses were conducted to examine the risk factors for osteoporosis in AS patients.ResultsThe incidence rate ratio (IRR) of osteoporosis in AS patients was 2.17 times higher than that non-AS group (95% confidence interval [CI], 1.83–2.57). The adjusted HRs of osteoporosis for AS patients after controlling for demographic characteristics and comorbid medical disorders was 1.99 (95% CI 1.68–2.36). Among AS group, after adjustment for major comorbidities, old age (≥65 years, HR 4.32, 95% CI 3.01–6.18), female sex (HR 2.48, 95% CI 1.87–3.28), dyslipidemia (HR 1.44, 95% CI 1.01–2.06) were risk factors associated with osteoporosis.ConclusionsThis cohort study demonstrated that patients with AS had a higher risk of developing osteoporosis, especially in those aged over 65, female sex and with dyslipidemia in this patient group.

show abstract

“…Osteoporotic fractures, particularly hip fractures, result in disability related to difficulty with ambulation and the performance of activities of daily living [2] and are thus associated with increased nursing home and rehabilitation hospital admissions [2,3 & ]. Many inflammatory conditions that rheumatologists encounter, including rheumatoid arthritis (RA), psoriatic arthritis and ankylosing spondylitis, are associated with osteoporosis [5,6]. Many inflammatory conditions that rheumatologists encounter, including rheumatoid arthritis (RA), psoriatic arthritis and ankylosing spondylitis, are associated with osteoporosis [5,6].…”

Section: Introductionmentioning

confidence: 99%

Current approaches to osteoporosis treatment

Lim

Bolster²

2015

Current Opinion in Rheumatology

View full text Add to dashboard Cite

show abstract

Opportunistic Computed Tomography Screening Shows a High Incidence of Osteoporosis in Ankylosing Spondylitis Patients With Acute Vertebral Fractures

Cited by 20 publications

References 11 publications

Clinical practice recommendations for the use of imaging in the diagnosis and management of axial spondyloarthritis in Taiwan

Clinical practice recommendations for the use of imaging in the diagnosis and management of axial spondyloarthritis in Taiwan

Should clinicians pay more attention to the potential underdiagnosis of osteoporosis in patients with ankylosing spondylitis? A national population-based study in Taiwan

Current approaches to osteoporosis treatment

Contact Info

Product

Resources

About