OPRM1 and BDNF polymorphisms associated with a compensatory neurophysiologic signature in knee osteoarthritis patients

Gonçalves, Fernanda de Toledo; Marques, Lucas Murrins; Pessotto, Anne Victório; Barbosa, Sara Pinto; Imamura, Marta; Simis, Marcel; Fregni, Felipe; Battistella, Linamara

doi:10.1016/j.neucli.2023.102917

Cited by 4 publications

(1 citation statement)

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“…Several very recent clinical studies have found a correlation between BDNF polymorphism and inflammatory pain. Compared to non-carriers, subjects suffering from osteoarthritis with BDNF polymorphisms were less likely to improve pain after rehabilitation [224] and, at EEG, displayed decreased alpha oscillations in the frontal area, likely reflecting the disruption of resting states to also compensate for the increased injury associated with arthritis [225]. Other investigations have disclosed an association between BDNF polymorphism and fibromyalgia (reviewed in [226]), and a systematic review and meta-analysis study demonstrated that the circulating BDNF levels were significantly higher in patients suffering from fibromyalgia than in controls [227].…”

Section: Bdnf Polymorphisms Related To Pain Signalingmentioning

confidence: 99%

Brain-Derived Neurotrophic Factor, Nociception and Pain

Merighi

2024

Preprint

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This review article discusses the involvement of the Brain-Derived Neurotrophic Factor (BDNF) in the control of pain. BDNF, a neurotrophin known for its essential role in neuronal survival and plasticity, has garnered significant attention for its potential implications as a modulator of nociception and pain. This comprehensive review aims to provide insights into the multifaceted interactions between BDNF and pain pathways, encompassing both physiological and pathological pain conditions. I delve into the molecular mechanisms underlying BDNF's involvement in pain processing and discuss potential therapeutic applications of BDNF and its mimetics in managing pain. Furthermore, I highlight recent advancements and challenges in translating BDNF-related research into clinical practice.

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Section: Bdnf Polymorphisms Related To Pain Signalingmentioning

confidence: 99%

Brain-Derived Neurotrophic Factor, Nociception and Pain

Merighi

2024

Preprint

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Endogenous opiates and behavior: 2023

Bodnar

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Peptides

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Brain-Derived Neurotrophic Factor, Nociception, and Pain

Merighi

2024

Biomolecules

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This article examines the involvement of the brain-derived neurotrophic factor (BDNF) in the control of nociception and pain. BDNF, a neurotrophin known for its essential role in neuronal survival and plasticity, has garnered significant attention for its potential implications as a modulator of synaptic transmission. This comprehensive review aims to provide insights into the multifaceted interactions between BDNF and pain pathways, encompassing both physiological and pathological pain conditions. I delve into the molecular mechanisms underlying BDNF’s involvement in pain processing and discuss potential therapeutic applications of BDNF and its mimetics in managing pain. Furthermore, I highlight recent advancements and challenges in translating BDNF-related research into clinical practice.

show abstract

OPRM1 and BDNF polymorphisms associated with a compensatory neurophysiologic signature in knee osteoarthritis patients

Cited by 4 publications

References 57 publications

Brain-Derived Neurotrophic Factor, Nociception and Pain

Brain-Derived Neurotrophic Factor, Nociception and Pain

Endogenous opiates and behavior: 2023

Brain-Derived Neurotrophic Factor, Nociception, and Pain

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