Optic disc edema as a possible complication of Imatinib mesylate (Gleevec)

Abstract

Optic disc edema should be considered one of the complications associated with imatinib. We propose discontinuation of the treatment for a short period when optic disc edema occurs.

Bilateral papilledema on sunitinib therapy for advanced renal cell carcinoma

“…Fluid retention is a recognized side effect; however, its ocular complications are rare, and the more commonly reported manifestation is periorbital edema, rather than papilledema [13][14][15]. The current literature suggests the development of periorbital edema may be linked to PDGF receptor b inhibition; the receptor is thought to have a role in the regulation of interstitial fluid pressure and is avidly expressed on the dermal dendrocytes of the periorbital tissues [16,17].…”

Bartonella henselae neuroretinitis in a 15-year-old girl with chronic myelogenous leukemia

“…Imatinib was discontinued because it has been known to cause disk edema as a side effect in patients. 1 On 7-day follow-up examination, the patient's vision improved to 20/400 and her afferent pupillary defect resolved. Funduscopic examination revealed marked resolution of disk and macular edema along with a new appearance of lipid exudates in a macular star pattern.…”

Ocular side effects of biological agents in oncology: what should the clinician be aware of?

“…There are two reports in the literature about the development of optic disc edema under therapy with imatinib. One patient had unilateral disc edema, the other bilateral 36,37. It might represent a mild form of papillitis.…”