Optic Disc Melanocytoma Associated with Choroidal Neovascular Membrane: An Unusual Presentation

Management of Choroidal Neovascularization Associated with Optic Disc Melanocytoma with Intravitreal Aflibercept: A Case Report and Review of the Literature

“…There are several methods of management choroidal neovascular membrane associated with optic disc melanocytoma including photodynamic therapy, submacular surgery, and intravitreal anti-VEGF injection [3, 4, 9] (Table 1).…”

Optic nerve melanocytoma: pathophysiology, clinical considerations, and diagnostic novelties

“…In the second case, there was a choroidal neovascular membrane with macular edema, which was treated with bevacizumab with good visual results 12 . The incidence of this pathology has been described in 1% of patients with melanocytoma 12,34 .…”

“…Malignancy, although rare, is also possible, and has been evidenced in 1 to 2% of the cases 12,14,15,17,[19][20][21][22][23]25,34 . Some of the characteristics that may lead to suspicion of malignant transformation are, for example, a small lesion that initially only compromises the optic disc and then grows and extends causing visual loss secondary to vascular occlusion 9,10 .…”

“…By retinal fluorescein angiography, there is hypofluorescence and autohypofluorescence 4,19,21,34,38 , probably secondary to pigmented and densely compacted cells 19.38 , with relatively little vascularization and lipofuscin absence 38 . By autofluorescence, the adjacent retina is isoautofluorescent 41 .…”

“…Among the lesions that must be considered when evaluating a patient with suspected melanocytoma, are juxtapapillary choroidal melanocytoma, choroidal nevus, RPE hyperplasia, combined retinal hamartoma and RPE, RPE adenoma, melanoma of the optic nerve, peripapillary vitreous hemorrhage, choroidal melanoma and optic nerve pit, among others [24][25][26]34,37,40 .…”