Optic Flow Processing in Patients With Macular Degeneration

Guénot, Jade; Trotter, Yves; Fricker, Paul; Cherubini, Marta; Soler, V.; Cottereau, Benoit R.

doi:10.1167/iovs.63.12.21

Cited by 4 publications

(10 citation statements)

References 43 publications

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“…Our results are not totally in line with this observation as the scotoma effect in our data was independent of the age group and of the pattern. In a previous study based on the same experimental protocol 32 , we had found that performances were unaffected when central vision was masked. This discrepancy might be explained by the fact that the effect of the arti cial scotoma is small and only detectable with a large group of participants (n = 84 in this study versus n = 12 in the previous one).…”

Section: Discussionmentioning

confidence: 81%

“…Rotational patterns are very rarely used in studies on optic ow processing in humans (see however Strong et al 42 or Guénot et al 32 ) whereas this pattern is quite frequent in everyday life because of the head rotation during walking. Rather curiously, we found that older participants had lower thresholds than younger ones when they had to discriminate between noisy dot patterns rotating either clockwise or counterclockwise.…”

Section: Discussionmentioning

confidence: 99%

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Processing of ego-motion compatible optic flow in the elderly

Guénot,

Trotter,

Delaval

et al. 2023

Preprint

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Aging impacts human observer’s performance in a wide range of visual tasks and notably in motion discrimination. Despite numerous studies, we still poorly understand how optic flow processing is impacted in the elderly. Here, we estimated motion coherence thresholds in two groups of young (age: 18–30, n = 42) and old (70–90, n = 42) adult participants for the three components of optic flow (translational, radial and rotational patterns). Stimuli were dynamic random-dot kinematograms (RDKs) projected on a large screen. Participants had to report their perceived direction of motion (leftward versus rightward for translational, inward versus outward for radial and clockwise versus anti-clockwise for rotational patterns). Stimuli had an average speed of 7°/s (additional recordings were performed at 14°/s) and were either presented full-field or with an artificial scotoma masking central vision. Statistical analyses showed that if thresholds in older adults were similar to those measured in younger participants for translational patterns, thresholds for radial patterns were significantly increased in our slowest condition and thresholds for rotational patterns were significantly decreased. Altogether, these findings support the idea that aging does not lead to a general decline in visual perception but rather has specific effects on the processing of each optic flow component.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Processing of ego-motion compatible optic flow in the elderly

Guénot,

Trotter,

Delaval

et al. 2023

Preprint

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“…Studies examining motion perception (in terms of both threshold and direction detection) have found similar performance in older adults with and without CFL. 53 , 59 Loss of the central visual field, therefore, does not limit (or enhance) individuals’ ability to accurately detect and process visual motion, although it also does not appear to enhance these functions. Others have found a similar degree of vection—the feeling of self-motion induced by dynamic visual cues—in both eyes of individuals with monocular CFL 60 and between individuals with and without CFL.…”

Section: Discussionmentioning

confidence: 99%

Visual Field Dependence Persists in Age-Related Central Visual Field Loss

Agathos,

Shanidze

2024

Invest. Ophthalmol. Vis. Sci.

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Purpose To examine whether the age-related increase in visual field dependence persists in older adults with central field loss (CFL). Methods Twenty individuals with CFL were grouped into participants with age-related binocular CFL (CFL, n = 9), age-related monocular CFL/relative scotomata (mCFL, n = 8), and CFL occurring at a young age (yCFL, n = 3). Seventeen controls were age-matched to the older CFL groups (OA) and three to the yCFL group (yOA). Participants judged the tilt direction of a rod presented at various orientations under conditions with and without a visual reference. Visual field dependence was determined as the difference in judgment bias between trials with and without the visual reference. Visual field dependence was examined between groups and relative to visual acuity and contrast sensitivity. Results All older groups performed similarly without the visual reference. The CFL group showed greater visual field dependence than the OA group (Mann–Whitney U test; U = 39, P = 0.045). However, there was no group difference when considering all three older groups (Kruskal–Wallis ANOVA; H (2, N = 34) = 4.31, P = 0.116). Poorer contrast sensitivity correlated with greater visual field dependence ( P = 0.017; ρ = −0.43). Conclusions Visual field dependence persists in older adults with CFL and seems exacerbated in those with dense binocular scotomata. This could be attributed to the sensitivity of the spared peripheral retina to orientation and motion cues. The relationship with contrast sensitivity further suggests that a decline in visual function is associated with an increase in visual field dependence beyond the effects of normal aging. These observations can guide tailored care and rehabilitation in older adults with CFL.

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“…For each participant, the position of the PRL was determined following the trilateration procedure described by Maniglia et al (2018) (see also Guénot et al, 2022 ). First, the fovea was localized through a high-resolution scan of the retinal fundus with a Spectral-Domain Optical Coherence Tomography (Spectralis OCT, Heidelberg Engineering, Heidelberg, Germany).…”

Section: Methodsmentioning

confidence: 99%

tRNS boosts visual perceptual learning in participants with bilateral macular degeneration

Contemori,

Maniglia,

Guénot

et al. 2024

Front. Aging Neurosci.

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Perceptual learning (PL) has shown promise in enhancing residual visual functions in patients with age-related macular degeneration (MD), however it requires prolonged training and evidence of generalization to untrained visual functions is limited. Recent studies suggest that combining transcranial random noise stimulation (tRNS) with perceptual learning produces faster and larger visual improvements in participants with normal vision. Thus, this approach might hold the key to improve PL effects in MD. To test this, we trained two groups of MD participants on a contrast detection task with (n = 5) or without (n = 7) concomitant occipital tRNS. The training consisted of a lateral masking paradigm in which the participant had to detect a central low contrast Gabor target. Transfer tasks, including contrast sensitivity, near and far visual acuity, and visual crowding, were measured at pre-, mid and post-tests. Combining tRNS and perceptual learning led to greater improvements in the trained task, evidenced by a larger increment in contrast sensitivity and reduced inhibition at the shortest target to flankers’ distance. The overall amount of transfer was similar between the two groups. These results suggest that coupling tRNS and perceptual learning has promising potential applications as a clinical rehabilitation strategy to improve vision in MD patients.

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Optic Flow Processing in Patients With Macular Degeneration

Cited by 4 publications

References 43 publications

Processing of ego-motion compatible optic flow in the elderly

Processing of ego-motion compatible optic flow in the elderly

Visual Field Dependence Persists in Age-Related Central Visual Field Loss

tRNS boosts visual perceptual learning in participants with bilateral macular degeneration

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