Optic Nerve Tilt, Crescent, Ovality, and Torsion in a Multi-Ethnic Cohort of Young Adults With and Without Myopia

Marsh‐Tootle, Wendy; Harb, Elise; Hou, Wei; Zhang, Qinghua; Anderson, Heather A; Weise, Katherine K.; Norton, Thomas T.; Gwiazda, Jane; Hyman, Leslie

doi:10.1167/iovs.16-20860

Cited by 27 publications

(42 citation statements)

References 46 publications

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“…Tumors that only affect the ON are referred to as optic nerve gliomas (ONGs). In general, OPGs are uncommon and account for only about 1% of intracranial tumors [69]. However, they are the most common primary tumors of the optic nerve, comprising about 65% of all intrinsic ON tumors [70].…”

Section: Primary Tumors Of the Optic Nerve 41 Optic Pathway Glioma mentioning

confidence: 99%

“…More than two-thirds of OPGs are detected in the first decade of life and up to 90% before the end of the second decade [69]. ONGs are most often benign and slowly growing.…”

Section: Primary Tumors Of the Optic Nerve 41 Optic Pathway Glioma mentioning

confidence: 99%

“…ONGs are most often benign and slowly growing. The most common presenting findings in descending order are proptosis (94%), vision loss (87.5%), optic disc pallor (59%), disc edema (35%), and strabismus (27%) [69]. However, the presentation of ONGs is variable and mostly depends on the segment of the optic nerve affected by the tumor.…”

Section: Primary Tumors Of the Optic Nerve 41 Optic Pathway Glioma mentioning

confidence: 99%

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Optic Nerve: Developmental Anomalies and Common Tumors

Alkatan¹,

Alshowaeir²,

Alzahem³

2019

Optic Nerve

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The optic nerve, also known as the second cranial nerve, is composed of axons that transmit visual information from the neurosensory retina to the visual cortex. There are multiple pathologies that can affect the human optic nerve. Congenital anomalies of the optic nerve include myelinated nerve fibers, morning glory syndrome, optic nerve choristoma, optic nerve coloboma, optic nerve hypoplasia and aplasia, and others. Tumors that can affect the optic nerve (ON) may occur primarily from within the nerve itself, from the surrounding optic nerve sheath (ONS), or secondarily spreading to the nerve from a distant site. They include optic pathway glioma, medulloepithelioma, oligodendroglioma, optic nerve sheath meningioma, and others. Here in this chapter, we will review the optic nerve anatomy, embryology, and physiology in addition to assessment of optic nerve function. Moreover, the clinical features, imaging findings, pathology, and treatment options of the most common and some rare congenital anomalies and primary tumors of the ON and sheath will be reviewed.

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Section: Primary Tumors Of the Optic Nerve 41 Optic Pathway Glioma mentioning

confidence: 99%

“…More than two-thirds of OPGs are detected in the first decade of life and up to 90% before the end of the second decade [69]. ONGs are most often benign and slowly growing.…”

Section: Primary Tumors Of the Optic Nerve 41 Optic Pathway Glioma mentioning

confidence: 99%

Section: Primary Tumors Of the Optic Nerve 41 Optic Pathway Glioma mentioning

confidence: 99%

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Optic Nerve: Developmental Anomalies and Common Tumors

Alkatan¹,

Alshowaeir²,

Alzahem³

2019

Optic Nerve

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“…However, PPA -BM was associated with a longer axial length but not with glaucoma [2][3][4][5]. A previous study showed that optic nerve head (ONH) tilt was associated with PPA +BM and PPA -BM widths, which suggested that the microstructure of PPA might reflect the myopic remodeling of the ONH [6]. However, PPA's formation and significance are not fully understood.…”

Section: Introductionmentioning

confidence: 98%

Association of macular thickness with parapapillary atrophy in myopic eyes

Piao

Guo

et al. 2020

BMC Ophthalmol

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Background: To investigate whether macular structure could be affected by axial elongation and to determine the association between macular intraretinal thickness and the microstructure of β-zone parapapillary atrophy (PPA) in myopic eyes. Methods: The study recruited 113 healthy myopic subjects (113 eyes). Images of the macula, subfoveal choroid, and optic nerve head were acquired using spectral-domain optical coherence tomography (SD-OCT). An automatic segmentation algorithm was used to segment the macular images into 7 intraretinal layers. PPA widths with and without Bruch's membrane (PPA +BM and PPA-BM , respectively) were evaluated. Linear regression analysis was performed to evaluate the association between macular intraretinal thickness and axial length and the microstructure of PPA. Results: An increase in axial length was associated with a decrease in whole macular thickness of the peripheral region and an increase in whole macular thickness of the central region. Thickness alterations of the macular intraretinal layers were most apparent in the peripheral region. A significant correlation was found between PPA-BM width and macular intraretinal layer thickness, whereas no significant correlation was found between PPA +BM width and macular intraretinal layer thickness. Moreover, both PPA +BM and PPA-BM widths significantly correlated with subfoveal choroidal thickness. Conclusions: Macular intraretinal layer thickness may be affected by PPA-BM width. These findings indicate that the microstructure of PPA should be considered when evaluating the macula in patient with myopia and glaucoma.

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Section: Introductionmentioning

confidence: 98%

Association of macular thickness with parapapillary atrophy in myopic eyes

Piao

Guo

et al. 2020

Preprint

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KEYWORDSmacular thickness, axial length, myopia, β-parapapillary atrophy with Bruch's membrane, β-parapapillary atrophy without Bruch's membrane Abstract Background: To investigate whether macular structure could be affected by axial elongation and to determine the association between macular intraretinal thickness and the microstructure of β-zone parapapillary atrophy (PPA) in myopic eyes. Methods:The study recruited 113 healthy myopic subjects (113 eyes). Images of the macula, subfoveal choroid, and optic nerve head were acquired using spectral-domain optical coherence tomography (SD-OCT). An automatic segmentation algorithm was used to segment the macular images into 7 intraretinal layers. PPA widths with and without Bruch's membrane (PPA +BM and PPA -BM , respectively) were evaluated. Linear regression analysis was performed to evaluate the association between macular intraretinal thickness and axial length and the microstructure of PPA. Results: An increase in axial length was associated with a decrease in whole macular thickness of the peripheral region and an increase in whole macular thickness of the central region. Thickness alterations of the macular intraretinal layers were most apparent in the peripheral region. A significant correlation was found between PPA -BM width and macular intraretinal layer thickness, whereas no significant correlation was found between PPA +BM width and macular intraretinal layer thickness. Moreover, both PPA +BM and PPA -BM widths significantly correlated with subfoveal choroidal thickness. Conclusions: Macular intraretinal layer thickness may be affected by PPA -BM width. These findings indicate that the microstructure of PPA should be considered when evaluating the macula in patient with myopia and glaucoma.

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Optic Nerve Tilt, Crescent, Ovality, and Torsion in a Multi-Ethnic Cohort of Young Adults With and Without Myopia

Cited by 27 publications

References 46 publications

Optic Nerve: Developmental Anomalies and Common Tumors

Optic Nerve: Developmental Anomalies and Common Tumors

Association of macular thickness with parapapillary atrophy in myopic eyes

Association of macular thickness with parapapillary atrophy in myopic eyes

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