Optical and MRI Multifunctional Nanoprobe for Targeting Gliomas

Veiseh, Omid; Sun, Conroy; Gunn, Jonathan; Kohler, Nathan; Gabikian, Patrik; Lee, Dong‐Hoon; Bhattarai, Narayan; Ellenbogen, Richard G.; Sze, Raymond W.; Hallahan, Andrew R.; Olson, Jim; Zhang, Miqin

doi:10.1021/nl0502569

Cited by 538 publications

(416 citation statements)

References 21 publications

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“…69 In this case, the contrast agent consisted of a SPIOchlorotoxin peptide conjugate. 148 In another embodiment, SPIO-herceptin was able to mark the HEr-2/neu (c-erb B-2) tyrosine kinase receptor. 9,44 This target has been found to be overexpressed on breast cancer cells in 25% of women with metastatic breast cancer.…”

Section: Cancer Imagingmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

et al. 2006

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Abstract-The field of molecular imaging has recently seen rapid advances in the development of novel contrast agents and the implementation of insightful approaches to monitor biological processes non-invasively. In particular, superparamagnetic iron oxide nanoparticles (SPIO) have demonstrated their utility as an important tool for enhancing magnetic resonance contrast, allowing researchers to monitor not only anatomical changes, but physiological and molecular changes as well. Applications have ranged from detecting inflammatory diseases via the accumulation of non-targeted SPIO in infiltrating macrophages to the specific identification of cell surface markers expressed on tumors. In this article, we attempt to illustrate the broad utility of SPIO in molecular imaging, including some of the recent developments, such as the transformation of SPIO into an activatable probe termed the magnetic relaxation switch.

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Section: Cancer Imagingmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

et al. 2006

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“…Through interaction with MMP-2/MT1-MMP it induces the internalization into caveolar rafts and, within 10-30 minutes depletes Cl − channels from the cell surface. Internalization occurs in conjunction with the Cltx peptide (Deshane et al, 2003) and this feature has been exploited recently to manufacture a Cltx-based multi-functional nanoprobe that either targets glioma cells or detecting them by magnetic resonance imaging and fluorescence microscopy (Veiseh et al, 2005). Moreover, the finding that the molecule is captured intracellularly by tumor cells and, hence, cannot be cleared explains why [131]I-labeled Cltx is still visualized in tumors 8 days after administration in clinical trials (Hockaday et al, 2005).…”

Section: A Putative CL − Channel Inhibitor (Cltx) Is Currently In Climentioning

confidence: 99%

A role for ion channels in glioma cell invasion

McFerrin¹,

2005

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Many cells, including neuronal and glial progenitor cells, stem cells and microglial cells, have the capacity to move through the extracellular spaces of the developing and mature brain. This is particularly pronounced in astrocyte-derived tumors, gliomas, which diffusely infiltrate the normal brain. Although a significant body of literature exists regarding signals that are involved in the guidance of cells and their processes, little attention has been paid to cell-shape and cell-volume changes of migratory cells. However, extracellular spaces in the brain are very narrow and represent a major obstacle that requires cells to dynamically regulate their volume. Recent studies in glioma cells show that this involves the secretion of Cl − and K + with water. Pharmacological inhibition of Cl − channels impairs their ability to migrate and limits tumor progression in experimental tumor models. One Cl − -channel inhibitor, chlorotoxin, is currently in Phase II clinical trials to treat malignant glioma. This article reviews our current knowledge of cell-volume changes and the role of ion channels during the migration of glioma cells. It also discusses evidence that supports the importance of channel-mediated cell-volume changes in the migration of immature neurons and progenitor cells during development. New unpublished data is presented, which demonstrates that Cl − and K + channels involved in cell shrinkage localize to lipid-raft domains on the invadipodia of glioma cells and that their presence might be regulated by trafficking of these proteins in and out of lipid rafts.

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“…However, it has been shown that as the reverse micelle is heated up, improvement of the crystallinity of iron oxide and other ferrite is achieved. [129] In addition, scaling up is complicated due to the sensitivity of preparation conditions, the need for large amounts of organic solvent, and difficulty to remove the surfactants.…”

Section: Reverse Micelle (Microemulsion)mentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

203

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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Optical and MRI Multifunctional Nanoprobe for Targeting Gliomas

Cited by 538 publications

References 21 publications

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

A role for ion channels in glioma cell invasion

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

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