Optical and surface plasmon resonance sensing properties for chitosan/carboxyl-functionalized graphene quantum dots thin film

Ramdzan, Nur Syahira Md; Fen, Yap Wing; Omar, Nur Alia Sheh; Anas, Nur Ain Asyiqin; Daniyal, ‬Wan Mohd Ebtisyam Mustaqim Mohd; Saleviter, Silvan; Zainudin, Afiq Azri

doi:10.1016/j.ijleo.2018.10.071

Cited by 50 publications

(28 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Surface plasmon resonance (SPR) sensing. SPR measurements were conducted based on Kretschmann configuration [65][66][67][68] by evaporating Au/DSU/NH 2 rGO-PAMAM/IgM sensor film onto the prism surface. The prism was placed on an optical stage driven by a stepper motor with a resolution of 0.001° (Newport MM 3000) to let the incident light from laser beam (632.8 nm, 5 mW) pass through the prism and hits a gold layer to generate the surface plasmon waves at the interface.…”

mentioning

confidence: 99%

Sensitive Detection of Dengue Virus Type 2 E-Proteins Signals Using Self-Assembled Monolayers/Reduced Graphene Oxide-PAMAM Dendrimer Thin Film-SPR Optical Sensor

Omar

Fen

Abdullah

et al. 2020

Sci Rep

Self Cite

123

View full text Add to dashboard Cite

In this work, sensitive detection of dengue virus type 2 E-proteins (DENV-2 E-proteins) was performed in the range of 0.08 pM to 0.5 pM. The successful DENV detection at very low concentration is a matter of concern for targeting the early detection after the onset of dengue symptoms. Here, we developed a SPR sensor based on self-assembled monolayer/reduced graphene oxide-polyamidoamine dendrimer (SAM/NH 2 rGO/PAMAM) thin film to detect DENV-2 E-proteins. Surface characterizations involving X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR) confirms the incorporation of NH 2 rGO-PAMAM nanoparticles in the prepared sensor films. The specificity, sensitivity, binding affinity, and selectivity of the SPR sensor were then evaluated. Results indicated that the variation of the sensing layer due to different spin speed, time incubation, and concentration provided a better interaction between the analyte and sensing layer. The linear dependence of the SPR sensor showed good linearity (R 2 = 0.92) with the lowest detection of 0.08 pM DENV-2 E-proteins. By using the Langmuir model, the equilibrium association constant was obtained at very high value of 6.6844 TM −1 (R 2 = 0.99). High selectivity of the SPR sensor towards DENV-2 E-proteins was achieved in the presence of other competitors. Dengue virus (DENV) is the most common arthropod-borne viral disease that poses a serious global problem. According to World Health Organization (WHO), the dengue virus is the leading cause of death of 22 000, annually. As of today, the need for hospitalization and medical treatment are constantly dense due to the fact that 390 million people in the world are still infected with DENV 1. Its four distinct serotypes (DENV-1. DENV-2, DENV-3, and DENV-4) are capable of causing a range of clinical symptoms ranging from mild fevers to the severe dengue haemorrhagic fever (DHF) and be potentially life-threatening 2-10. Despite its large burden to human health, no effective vaccine and antiviral therapy are available for the virus 11,12. Early treatment for DENV is only by maintaining the body fluid of the patient, as it is critical in fighting the severe symptoms of DENV 13,14. Hence, an early, rapid, and accurate diagnosis at the onset of infection is the demand of the day in the most epidemic settings. Present discoveries in dengue diagnostics that can help in the early diagnosis are targeting the host-virus itself. DENV consists of a single-stranded positive-sense RNA virus that encodes 10 different types of proteins. Seven of

show abstract

mentioning

confidence: 99%

Sensitive Detection of Dengue Virus Type 2 E-Proteins Signals Using Self-Assembled Monolayers/Reduced Graphene Oxide-PAMAM Dendrimer Thin Film-SPR Optical Sensor

Omar

Fen

Abdullah

et al. 2020

Sci Rep

Self Cite

123

View full text Add to dashboard Cite

show abstract

“…Recently, Ramdzan et al designed an SPR sensor using chitosan and carboxyl-functionalized GQDs [361]. The existence of C=O, C-O, C-H and O-H bonds in a thin film comprising GQDs and chitosan was confirmed by FT-IR spectra, while its optical characteristics were approved by UV-Vis and PL spectroscopy.…”

Section: Photoelectrochemical and Miscellaneous Gqd Sensors In Biomedmentioning

confidence: 99%

“…Schematic representation of an surface plasmon resonance (SPR)sensor. Adapted from Ramdzan et al[361].…”

mentioning

confidence: 99%

Applications of Graphene Quantum Dots in Biomedical Sensors

Mansuriya

Altıntaş

2020

Sensors

190

View full text Add to dashboard Cite

Due to the proliferative cancer rates, cardiovascular diseases, neurodegenerative disorders, autoimmune diseases and a plethora of infections across the globe, it is essential to introduce strategies that can rapidly and specifically detect the ultralow concentrations of relevant biomarkers, pathogens, toxins and pharmaceuticals in biological matrices. Considering these pathophysiologies, various research works have become necessary to fabricate biosensors for their early diagnosis and treatment, using nanomaterials like quantum dots (QDs). These nanomaterials effectively ameliorate the sensor performance with respect to their reproducibility, selectivity as well as sensitivity. In particular, graphene quantum dots (GQDs), which are ideally graphene fragments of nanometer size, constitute discrete features such as acting as attractive fluorophores and excellent electro-catalysts owing to their photo-stability, water-solubility, biocompatibility, non-toxicity and lucrativeness that make them favorable candidates for a wide range of novel biomedical applications. Herein, we reviewed about 300 biomedical studies reported over the last five years which entail the state of art as well as some pioneering ideas with respect to the prominent role of GQDs, especially in the development of optical, electrochemical and photoelectrochemical biosensors. Additionally, we outline the ideal properties of GQDs, their eclectic methods of synthesis, and the general principle behind several biosensing techniques.

show abstract

“…. Although CG was widely applied in semiconductors , , supercapacitors , electrochemiluminescence , biosensors , and hydrogels , less literature is available on its application in membrane separation comparing with GO. To the best of our knowledge, Gao et al , prepared CG and CG/polyamide nanofiltration membranes and applied them for dye solution desalination.…”

Section: Introductionmentioning

confidence: 99%

Poly(vinyl alcohol)/Carboxyl Graphene Membranes for Ethanol Dehydration by Pervaporation

et al. 2020

View full text Add to dashboard Cite

Carboxyl graphene (CG) with two functions of hybridization and crosslinking was incorporated into poly(vinyl alcohol) (PVA) matrix to form PVA/CG mixed‐matrix membranes (MMMs). The membranes demonstrated excellent mechanical properties and thermal stability. The improved hydrophilicity and formed crosslinking structure led to moderate swelling. The membrane crystallinity decreased and the free volume was promoted with increasing CG loading amount. The pervaporation (PV) separation performance for ethanol dehydration indicated that both permeation flux and separation factor were enhanced simultaneously at the optimum CG loading. Subsequently, the permeation flux continued to increase while the separation factor declined at higher CG loadings.

show abstract

Optical and surface plasmon resonance sensing properties for chitosan/carboxyl-functionalized graphene quantum dots thin film

Cited by 50 publications

References 25 publications

Sensitive Detection of Dengue Virus Type 2 E-Proteins Signals Using Self-Assembled Monolayers/Reduced Graphene Oxide-PAMAM Dendrimer Thin Film-SPR Optical Sensor

Sensitive Detection of Dengue Virus Type 2 E-Proteins Signals Using Self-Assembled Monolayers/Reduced Graphene Oxide-PAMAM Dendrimer Thin Film-SPR Optical Sensor

Applications of Graphene Quantum Dots in Biomedical Sensors

Poly(vinyl alcohol)/Carboxyl Graphene Membranes for Ethanol Dehydration by Pervaporation

Contact Info

Product

Resources

About