Optical Coherence Tomography and Histopathology Assessment After Implantation of First- and Second-Generation Drug-Eluting Stents in a Porcine Coronary Model

Vessel Response After First- and Second-Generation Drug-Eluting Stent Detected by Optical Coherence Tomography

“…13 Otsuka et al found that the inflammation score was low and fibrin deposition less frequent in lesions treated with EES than in those with SES or paclitaxel-eluting stent (PES). These results are concordant with those of the present study by Hiranuma et al 11 Interestingly, despite the differences in inflammation, neoatherosclerosis was similarly found in lesions treated with SES, PES and EES. Again, pathological examination does not provide serial changes of the same stented lesion.…”

A comparison of drug eluting stent biocompatibility between third generation NOBORI biolimus A9-eluting stent and second generation XIENCE V everolimus-eluting stent in a porcine coronary artery model

“…Nakazawa reported that BES and EES showed similar biocompatibility while sirolimus-eluting stents (SES) showed severe inflammatory reactions in porcine coronary arteries [11]. Also, Hiranuma showed no significant differences between BES and EES by optical coherence tomography at one month after stent implantation [12]. Nevertheless, we recognized superiority of BES to EES in the current experiments.…”

“…Similar with recent clinical trials, most of previous preclinical studies comparing BES and EES have failed to show the differences between the biodegradable polymer stents and the durable polymer stents [11,12]. Nakazawa reported that BES and EES showed similar biocompatibility while sirolimus-eluting stents (SES) showed severe inflammatory reactions in porcine coronary arteries [11].…”

Association of Adventitial Vasa Vasorum and Inflammation With Coronary Hyperconstriction After Drug-Eluting Stent Implantation in Pigs In Vivo

“…Third, vascular healing processes in the present study with Göttingen miniature pigs, including neointimal formation and inflammation, were different from those in the previous study with Yukatan miniature pigs; 34 this was probably due to differences in the extent of vascular injury and species of miniature pigs. 35 Fourth, we used intracoronary serotonin to examine coronary vasoconstriction, as previously described. 13- 16 It is known that in porcine coronary arteries, acetylcholine does not cause endothelium-dependent relaxations due to the lack of cholinergic receptors on the endothelium.…”