Optical coherence tomography angiography and Humphrey field analyser for macular capillary non-perfusion evaluation in branch retinal vein occlusion

Abstract

We non-invasively evaluated macular non-perfused areas (m-NPAs) of branch retinal vein occlusion (BRVO) using optical coherence tomography (OCT) angiography and the Humphrey visual field analyser 10-2 programme (HFA 10-2). We enrolled 30 patients (30 eyes) with macular oedema secondary to BRVO. OCT angiography was used to photograph the macula at 6 × 6-mm; sizes of m-NPAs in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were measured in four areas. For HFA 10-2, we divided the actual measurement threshold of 68 points into four areas and calculated the mean central visual field sensitivity (CVFS). The correlation between the mean m-NPA and mean CVFS (dB) in each area was examined. There was a strong correlation between the m-NPA of each region detected in SCP and DCP, and the mean CVFS of each corresponding area (SCP: r = − 0.83, r = − 0.64, r = − 0.73, and r = − 0.79; DCP: r = − 0.82, r = − 0.71, r = − 0.71, and r = − 0.70), p values were < 0.001 for all. m-NPAs were associated with decreased visual field sensitivity in BRVO. Non-invasive m-NPA evaluation was possible using OCT angiography and HFA 10-2.

Relationship Between Retinal Hemorrhage on Green and Red Channels of Ultra-Widefield Fundus Images and Retinal Perfusion in Acute Branch Retinal Vein Occlusion

“…Although optical coherence tomography angiography allows for rapid and noninvasive assessment of retinal microvascular status, it is generally suitable for evaluating NPAs in the macula only. 22 Most devices have a limited imaging range, and even with a montage of multiple guide direction images, they cannot match the range of UWFFA. 20 Moreover, large retinal hemorrhages in acute BRVO may result in poor image quality, which hampers the evaluation of NPAs.…”

Anti-Vascular Endothelial Growth Factor Treatment for Macular Edema in Eyes with Branch Retinal Vein Occlusion with vs Without Glaucoma – Does Glaucoma Affect Visual Outcome in Eyes with BRVO-ME After antiVEGF Injections?

“… 21 The visual field sensitivity reduction reflects the non-perfusion region caused by ischemic damage in BRVO with a strong correlation. 22 Moreover, several reports have mentioned RNFL reduction in eyes with BRVO, which implies degeneration of retinal ganglion cells. 23 , 24 Although we considered the possibility of some relationships between BRVO and glaucoma, since the present study was based on a retrospective medical record review, there was no systematic information other than the open-angle glaucoma diagnosis before the onset of BRVO-ME.…”