Optical coherence tomography angiography changes in cardiovascular systemic diseases and risk factors: A Review

Monteiro-Henriques, Inês; Rocha‐Sousa, Amândio; Breda, João Barbosa

doi:10.1111/aos.14851

Cited by 54 publications

(52 citation statements)

References 64 publications

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“…Indeed, previous studies have already outlined, using arterial spin labeling MRI scans, the contribution of vascular factors in the detection of other neurodegenerative disorders, such as Alzheimer's disease, mild cognitive impairment, and Parkinson's disease [31,32]. Moreover, several studies reported the close relationship between the alterations in retinal perfusion by OCTA and the systemic vascular impairment involving cardiovascular and central nervous systems [33,34]. These results supported the hypothesis that retinal VD could represent a valid biomarker to detect the early systemic vascular damages.…”

Section: Discussionmentioning

confidence: 98%

Retinal and Choriocapillary Vascular Changes in Early Stages of Multiple Sclerosis: A Prospective Study

Montorio

Lanzillo

Carotenuto

et al. 2021

JCM

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Optical Coherence Tomography Angiography (OCTA) abnormalities occur in multiple sclerosis (MS) over the course of the disease. OCTA investigations at early MS stages are lacking. We aimed to investigate vessel density in macular and papillary regions over two years after an initial demyelinating event (IDE). Vessel density was analyzed in superficial, deep, choriocapillaris and radial peripapillary plexus at baseline, and after one and two years. We also evaluated structural OCT parameter changes of the ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL). We evaluated 30 eyes from 15 IDE patients (7 females, 8 males, mean age 28.4 ± 9.6 years) and 30 eyes from 15 healthy controls. After 2 years, we reported in the IDE group a reduced vessel density in the superficial capillary plexus, deep capillary plexus and radial peripapillary capillary plexus with respect to the baseline (coeff. β = −2.779, p = 0.013; coeff. β = −4.055, p = 0.018 and coeff. β = −2.687, p ≤ 0.001; respectively), while GCC and RNFL thicknesses did not change. Vessel density reduction was not associated with an expanded disability status scale (EDSS) change, relapse occurrence or magnetic resonance imaging activity. The analysis of healthy controls did not reveal any impairment in OCT and OCTA parameters over 2 years of follow-up. Retinal vascular loss occurs in patients with an IDE independently from clinical and radiological disease activity. Retinal vessel density could represent a novel early biomarker to monitor the MS pathological burden.

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Section: Discussionmentioning

confidence: 98%

Retinal and Choriocapillary Vascular Changes in Early Stages of Multiple Sclerosis: A Prospective Study

Montorio

Lanzillo

Carotenuto

et al. 2021

JCM

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“…In conclusion, the present study demonstrated that OCT is an objective method of diagnosis that can inform us about OSAS patients' clinical situations in an easy and noninvasive way by studying the retinal structure. As recent reviews also confirm [54,55], OCT could be useful for undertaking the follow-up of the treatment of this disorder, showing retinal changes that help to monitor endothelial dysfunction in OSAS, such as foveal thickness and the average thickness of retinal nerve fibers. In severe OSAS, retina thickness increased six months after treatment.…”

Section: Discussionmentioning

confidence: 90%

Assessment of the Effectiveness of Obstructive Sleep Apnea Treatment Using Optical Coherence Tomography to Evaluate Retinal Findings

Tejero-Garcés

Puyuelo

Casas

et al. 2022

JCM

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Retinal findings may change in patients with obstructive sleep apnea syndrome (OSAS). The present study aims to evaluate several retinal findings, such as macula layer thickness, the peripapillary retinal nerve fiber layer, and the optic nerve head in patients with OSAS, using optical coherence tomography (OCT); it also aims to monitor the result of several types of treatment of OSAS with OCT. A prospective comparative study was designed. Patients were recruited at a Sleep Unit of a University Hospital and underwent comprehensive ophthalmological examinations. Following exclusion criteria, fifty-two patients with OSAS were finally included. Patients were examined by OCT twice: once before treatment, and again after six months of treatment. In mild–moderate patients, where retinal swelling had been demonstrated, retinal thicknesses decreased [fovea (p = 0.026), as did inner ring macula (p = 0.007), outer ring macula (p = 0.015), and macular volume (p = 0.015)]. In severe patients, where retinal atrophy had been observed, retinal thickness increased [fovea (p < 0.001)]. No statistically significant differences in efficacy between treatments were demonstrated. In conclusion, OCT can evaluate the retina in patients with OSAS and help to monitor results after treatment. In severe OSAS, retinal thickness increased six months after treatment.

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“…In conclusion, the present study demonstrated that OCT is an objective method of diagnosis that can inform us about OSAS patients' clinical situation in an easy and noninvasive way by studying the retinal structure. As recent reviews also confirm [40,41], OCT could be useful to undertake the follow-up of the treatment of this disorder, showing retinal changes that help monitor endothelial dysfunction in OSAS, such as foveal thickness and retinal nerve fibers average thickness. In severe OSAS, retina thickness increased six months after treatment.…”

Section: Discussionmentioning

confidence: 92%

Assessment of the Effectiveness of Obstructive Sleep Apnea Treatment Using Optical Coherence Tomography to Evaluate Retinal Findings

Tejero-Garcés¹,

Puyuelo²,

Casas³

et al. 2021

Preprint

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Retinal findings may change in patients with obstructive sleep apnea syndrome (OSAS). The present study aims to evaluate several retinal findings such as macula layer thickness, peripapillary retinal nerve fiber layer, and the optic nerve head in patients with OSAS using optical coherence tomography (OCT) and monitor the result of several types of treatment of OSAS with OCT. A prospective comparative study was designed. Patients were recruited at a Sleep Unit of a University Hospital and underwent comprehensive ophthalmological examinations. Following exclusion criteria, fifty-two patients with OSAS were finally included. Patients were examined by OCT twice: first, before treatment; secondly, after six months of treatment. In mild-moderate patients, where retinal swelling has been demonstrated, retinal thicknesses decreased [fovea (p=0.026), as well as inner ring macula (p=0.007), outer ring macula (p=0.015), and macular volume (p=0.015)]. In severe patients, where retinal atrophy had been observed, retinal thickness increased [fovea (p&lt;0.001)]. No statistically significant differences in efficacy between treatments were demonstrated. In conclusion, OCT can evaluate the retina in patients with OSAS and help monitor results after treatment. In severe OSAS, retinal thickness increased six months after treatment.

show abstract

Optical coherence tomography angiography changes in cardiovascular systemic diseases and risk factors: A Review

Cited by 54 publications

References 64 publications

Retinal and Choriocapillary Vascular Changes in Early Stages of Multiple Sclerosis: A Prospective Study

Retinal and Choriocapillary Vascular Changes in Early Stages of Multiple Sclerosis: A Prospective Study

Assessment of the Effectiveness of Obstructive Sleep Apnea Treatment Using Optical Coherence Tomography to Evaluate Retinal Findings

Assessment of the Effectiveness of Obstructive Sleep Apnea Treatment Using Optical Coherence Tomography to Evaluate Retinal Findings

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