Optical coherence tomography angiography in children with spontaneously regressed retinopathy of prematurity

Mataftsi, Asimina; Dermenoudi, Maria; Dastiridou, Anna; Tsiampali, Chara; Androudi, Sofia; Brazitikos, Periklis; Ziakas, Nikolaos

doi:10.1038/s41433-020-1059-x

Cited by 12 publications

(30 citation statements)

References 9 publications

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“…Balasubramanian et al found increased vessel density at the fovea in SCP and DCP (1 mm circle of Early Treatment Diabetic Retinopathy Study (ETDRS) grid), without significant parafoveal changes (1-3 mm circle of ETDRS) (Balasubramanian et al 2019). These results were confirmed by two other studies using automated calculation (Chen et al 2019;Mataftsi et al 2020). In contrast, Nonobe et al found no vascular changes in the central ETDRS sector in ROP children compared to healthy controls (Nonobe et al 2019).…”

Section: Discussionsupporting

confidence: 58%

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Perinatal risk factors associated with central retinal changes in former preterm children on optical coherence tomography angiography

Lavric

Markelj

Ding

et al. 2021

Acta Ophthalmologica

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Purpose To assess the association between perinatal risk factors for retinopathy of prematurity (ROP) and central retinal structures of former preterm children seen on optical coherence tomography angiography (OCTA). Methods This prospective cohort study included 40 children with a history of preterm birth and 33 healthy full‐term children. We documented their birth weight, gestational age, other significant risk factors for ROP development and presence of ROP. Imaging was performed using swept‐source OCTA, and quantitative evaluation was performed. Analytic parameters included the area of foveal avascular zone (FAZ), foveal depth (FD), central subfoveal retinal thickness (CSFT) and capillary density index (CDI) of the deep and superficial capillary plexus. Results Preterm children had significantly smaller FAZ, lower FD and higher CSFT compared to controls (all p < 0.001). Both groups exhibited no differences in total CDI at the superficial (p = 0.969) and deep capillary plexus (p = 0.370). The duration of mechanical ventilation correlated negatively with FAZ and FD but positively with CSFT. The duration of supplemental oxygen treatment correlated negatively with FD. The presence of intraventricular haemorrhage correlated negatively with FAZ and FD but positively with CSFT. Regression analysis found that the duration of mechanical ventilation and the presence of bronchopulmonary dysplasia were associated with lower FD (p = 0.002 and 0.01, respectively) and higher CSFT (p = 0.002 and 0.028, respectively). Conclusion Central retinal anomalies were identified in former preterm children using OCTA. Macular changes were associated with several risk factors for ROP development.

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Section: Discussionsupporting

confidence: 58%

“…2019; Mataftsi et al. 2020). In contrast, Nonobe et al found no vascular changes in the central ETDRS sector in ROP children compared to healthy controls (Nonobe et al.…”

Section: Discussionmentioning

confidence: 99%

Perinatal risk factors associated with central retinal changes in former preterm children on optical coherence tomography angiography

Lavric

Markelj

Ding

et al. 2021

Acta Ophthalmologica

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“…Retinal structure and microvasculature in children born pre‐term, with or without retinopathy of prematurity (ROP), is usually abnormal 1–5 . Anatomical characteristics of the retinal vascular network including the foveal avascular zone (FAZ) are important to understand the impact of prematurity on the development of the fovea 3 .…”

Section: Introductionmentioning

confidence: 99%

“…Retinal structure and microvasculature in children born pre‐term, with or without retinopathy of prematurity (ROP), is usually abnormal. 1 , 2 , 3 , 4 , 5 Anatomical characteristics of the retinal vascular network including the foveal avascular zone (FAZ) are important to understand the impact of prematurity on the development of the fovea. 3 Premature children are more likely to present with a poorly defined foveal pit and a reduced or absent FAZ, known as foveal hypoplasia or fovea plana.…”

Section: Introductionmentioning

confidence: 99%

“…Studies involving mostly pre‐term children have attributed a reduced or absent FAZ and increased foveal thickness to subnormal postnatal development of the foveal area of the macula. 5 However, it is currently unclear if a reduced or absent FAZ will lead to future problems. 14 There are also other conditions such as nanophthalmos that can lead to a small FAZ.…”

Section: Introductionmentioning

confidence: 99%

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All retinas are not created equal: Fovea‐to‐macula thickness ratio and foveal microvasculature in healthy young children

Demir

Hovsepian

Pagels

et al. 2022

Ophthalmic Physiologic Optic

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Markers for the relationships between structural and microvasculature measures given by optical coherence tomography angiography are necessary to increase the diagnostic and prognostic value of this technique. The aim of this study was to investigate relationships between structural and microvasculature measures around the fovea in healthy eyes of healthy children. Methods:Observational cross-sectional study involving children aged 8-17 years, born at full-term, with no eye disease. The better of two 3 × 3 mm macular scans obtained with a Cirrus 5000HD-OCT was analysed. Images were corrected for lateral magnification errors. Vessel density and perfusion were measured with ImageJ/Fiji software for the superficial capillary plexus. Structural measures including foveal and macular thicknesses were performed manually. Results:The sample included 86 participants, 51 (59%) females. Mean age was 12.4 years (SD = 2.5); mean best-corrected acuity was −0.10 logMAR (SD = 0.09); mean refractive error was +0.59 D (SD = 1.3) and mean axial length was 23.1 mm (SD = 0.86). Mean area of the foveal avascular zone (AFAZ) was 0.20 mm 2 (SD = 0.88); median fovea-to-macula thickness ratio (FMTR) was 0.63 (IQR = 0.08); mean central vessel density was 12.42 mm −1 (SD = 2.78) and mean central perfusion was 38.66% (SD = 3.83). AFAZ was correlated with central vessel density (p < 0.001), perfusion (p < 0.001), foveal thickness (p < 0.001) and FMTR (p < 0.001). Central vessel density was correlated with foveal thickness (p < 0.001) and FMTR, (p = 0.01). Central perfusion was correlated with foveal thickness (p < 0.001) and FMTR, (p = 0.003). Conclusion:In this study, foveal thickness, FMTR and foveal microvasculature measurements were correlated. Clinicians need to be aware that shallow foveal pits and persistent foveal microvasculature are likely to occur in optical coherence tomography angiography images. In healthy eyes from healthy children, an atypical high FMTR and a small AFAZ may be associated with incomplete foveal development. The mechanism and functional implications of this remain unknown.

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Advances in the Management of Retinopathy of Prematurity

Katoch

Markan

Dogra

2022

Pediatric Ophthalmology

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Optical coherence tomography angiography in children with spontaneously regressed retinopathy of prematurity

Cited by 12 publications

References 9 publications

Perinatal risk factors associated with central retinal changes in former preterm children on optical coherence tomography angiography

Perinatal risk factors associated with central retinal changes in former preterm children on optical coherence tomography angiography

All retinas are not created equal: Fovea‐to‐macula thickness ratio and foveal microvasculature in healthy young children

Advances in the Management of Retinopathy of Prematurity

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