Optical coherence tomography angiography in glaucoma diagnosis

Kurysheva, N I; Маслова, Е. В.

doi:10.17116/oftalma2016132598-102

Cited by 11 publications

(2 citation statements)

References 23 publications

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“…5,6 In addition, many studies have demonstrated high diagnostic values of OCTA in primary open-angle glaucoma (POAG) and NTG eyes, and VD in OCTA is also highly correlated with mean deviation (MD) and pattern standard deviation (PSD) values in the VF examination. 7,8 Because VF testing measures visual function, it is theoretically more relevant than OCTA. However, VF testing requires cooperation and concentration from the patients, meaning it has lower repeatability and reproducibility.…”

Section: Introductionmentioning

confidence: 99%

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Correlation of Visual Field With Peripapillary Vessel Density Through Optical Coherence Tomography Angiography in Normal-Tension Glaucoma

Lin

Huang

Yeung

et al. 2020

Trans. Vis. Sci. Tech.

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Purpose To investigate the retinal vessel density (VD) in healthy and normal-tension glaucoma (NTG) eyes through optical coherence tomography angiography (OCTA) and to determine the correlation between VD and the retinal nerve fiber layer (RNFL) thickness and functional visual field (VF) defects for different locations. Methods A total of 74 NTG eyes and 24 healthy eyes were included. OCTA VD at 4.5 × 4.5 mm peripapillary region and 3.0 × 3.0 mm macula area, RNFL thickness, and VF pattern deviation results were individually analyzed on the basis of the Garway-Heath sectorization. Correlations between VD and VF/RNFL and VF were compared. Results In the NTG group, peripapillary VD, superficial macula VD, RNFL thickness, and ganglion cell complex thickness were significantly lower. In the whole peripapillary area and inferotemporal sector, anatomic correlations between VD and VF pattern deviation values were significantly higher than those between the RNFL thickness and VF values. In the subgroup analysis, VD was anatomically correlated with VF in early-, moderate-, and severe-stage NTG eyes, whereas the RNFL thickness was correlated with VF in moderate- and severe-stage NTG eyes. Conclusions We observed VD reduction in the peripapillary retina and superficial macula area in NTG eyes. The microvascular dropout of VD in the peripapillary retina, especially in the inferotemporal sector, provided a more accurate anatomic correlation with functional VF defects than that of the RNFL thickness, especially in early-stage NTG eyes. Translational Relevance In patients who cannot comply VF exam, VD is a good tool for disease detection.

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