Optical coherence tomography angiography in pseudophakic cystoid macular oedema compared to diabetic macular oedema: qualitative and quantitative evaluation of retinal vasculature

Sacconi, Riccardo; Corbelli, Eleonora; Carnevali, Adriano; Mercuri, Stefano; Rabiolo, Alessandro; Querques, Lea; Marchini, Giorgio; Bandello, Francesco; Querques, Giuseppe

doi:10.1136/bjophthalmol-2017-311240

Cited by 32 publications

(22 citation statements)

References 30 publications

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“…OCT angiography is an emerging noninvasive diagnostic technique that is increasingly used in clinical practice. 90 OCT angiography may be considered superior to FA owing to its ability to quantitatively measure retinal blood flow across separate layers, including the superficial capillary plexus and the deep capillary plexus, and can determine areas of decreased or absent retinal perfusion in the deep vascular plexus, localized to the cystoid spaces. 90,104 A comparison of a healthy eye and an eye with CME as presented by OCT and OCT angiography is shown in Fig.…”

Section: Diagnosis Of Cmementioning

confidence: 99%

Cystoid macular edema related to cataract surgery and topical prostaglandin analogs: Mechanism, diagnosis, and management

Holló

Aung

Cantor

et al. 2020

Survey of Ophthalmology

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Section: Diagnosis Of Cmementioning

confidence: 99%

Cystoid macular edema related to cataract surgery and topical prostaglandin analogs: Mechanism, diagnosis, and management

Holló

Aung

Cantor

et al. 2020

Survey of Ophthalmology

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“…Perfusion density of SCP and DVC was calculated through Mean's thresholding and binarization, according to previous studies ( Fig. 1) 17,18 . Perfusion density of CC was calculated through Phansalkar's thresholding (radius, 15 pixels) and binarization after removing from the analysis the CC directly beneath major superficial retinal vessels in order to eliminate potentially confounding shadow or projection artifacts (Fig.…”

Section: Oct-a Image Acquisition and Analysismentioning

confidence: 99%

Morphofunctional analysis of the retina in patients with type 1 diabetes without complications after 30 years of disease

Sacconi

Lamanna

Borrelli

et al. 2020

Sci Rep

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There is a lack of studies evaluating the sub-clinical retinal changes in patients with long-term type 1 diabetes mellitus (T1DM) and without history of systemic/ocular complications. The aim of this crosssectional study was to investigate sub-clinical structural and/or vascular retinal changes in patients with long-term (≥30 years) T1DM and without systemic/ocular complications ("happy few" patients) using structural optical coherence tomography (OCT), OCT-angiography and microperimetry. Twelve eyes of 12 consecutive T1DM patients (mean age 52 ± 12 years, mean duration of disease 35 ± 3 years, mean HbA1c level 7.3 ± 2.8%), without micro/macrovascular complications associated with long-standing T1DM, and twelve healthy subjects were consecutively included. No statistically significant differences were disclosed comparing patients and controls for age, sex, best-corrected visual acuity, central macular thickness, and choroidal thickness. Using OCT-angiography, we did not find any significant difference in foveal avascular zone area, perfusion density, vessel length density, and tortuosity. Moreover, no significant differences were disclosed in retinal nerve fiber layer and ganglion cell complex thickness using structural OCT. No differences were disclosed in retinal sensitivity by microperimetry. New diagnostic tools are able to confirm the presence of a particular population of patients with type 1 diabetes who have been completely spared from diabetic retinal complications. The finding of these "happy few" patients could help us to better understand and target future treatments for diabetes.Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and it develops in the majority of patients with long-standing type 1 diabetes mellitus (T1DM) 1 . For this reason, the American Diabetes Association (ADA) recommended a comprehensive ocular examination within 5 years after T1DM diagnosis in order to detect early signs of DR and to manage it promptly 2 . Retinal microaneurysms may represent the first visible clinical sign of DR and are secondary to small outpouchings of the retinal capillaries.Recently, new imaging technologies have enabled early identification of retinal structural and functional changes, even before DR is clinically evident. Optical coherence tomography angiography (OCT-A), a non-invasive dye-free imaging modality, provides a highly detailed view of the retinal and choroidal vasculature. Nowadays, optimized OCT-A algorithms may be used to detect early retinal and choriocapillaris (CC) microvascular flow alterations, which may be evident even before the DR presentation and may potentially result in irreversible retinal damage. As an example, De Carlo et al. 3 revealed OCT-A ability to detect foveal avascular zone (FAZ) remodeling and retinal capillary nonperfusion in T1DM patients without DR. Furthermore, both our group 4 and Simonett et al. 5 reported a significantly decreased perfusion density (PD) in the deep retinal vascular complex (DVC) in T1DM patients without evidence...

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“…Some instruments use their own proprietary software, these include Cirrus (AngioPlex software, Carl Zeiss Meditec, Inc., Dublin, CA, USA), [ 5 , 10 ] AngioVue software (Optovue, Inc., Fremont, CA, USA), [ 11 , 12 ] and RS -3000 Advance (Nidek, Gamagori, Japan). [ 6 ] In the majority of the studies, however, images are exported and post-processed with a variety of different thresholding methods, including fixed cutoffs, [ 13 – 15 ] dynamic cutoff (e.g., mean, [ 9 , 16 , 17 ] ImageJ [National Institutes of Health, Bethesda, MD] default algorithm, [ 18 ] Otsu’s algorithm), [ 19 , 20 ] prototype software, [ 21 , 22 ] and more complex methods combining preprocessing filters and multilevel thresholds strategies. [ 23 – 26 ] It is still uncertain whether different algorithms lead to the same or, at least, similar results and findings from many studies could have been influenced by the algorithm utilized.…”

Section: Introductionmentioning

confidence: 99%

Comparison of methods to quantify macular and peripapillary vessel density in optical coherence tomography angiography

et al. 2018

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PurposeTo compare macular and peripapillary vessel density values calculated on optical coherence tomography angiography (OCT-A) images with different algorithms, elaborate conversion formula, and compare the ability to discriminate healthy from affected eyes.MethodsCross-sectional study of healthy subjects, patients with diabetic retinopathy, and glaucoma patients (44 eyes in each group). Vessel density in the macular superficial capillary plexus (SCP), deep capillary plexus (DCP), and the peripapillary radial capillary plexus (RCP) were calculated with seven previously published algorithms. Systemic differences, diagnostic properties, reliability, and agreement of the methods were investigated.ResultsHealthy eyes exhibited higher vessel density values in all plexuses compared to diseased eyes regardless of the algorithm used (p<0.01). The estimated vessel densities were significantly different at all the plexuses (p<0.0001) as a function of method used. Inter-method reliability and agreement was mostly poor to moderate. A conversion formula was available for every method, except for the conversion between multilevel and fixed at the DCP. Substantial systemic, non-constant biases were evident between many algorithms. No algorithm outperformed the others for discrimination of patients from healthy subjects in all the retinal plexuses, but the best performing algorithm varied with the selected plexus.ConclusionsAbsolute vessel density values calculated with different algorithms are not directly interchangeable. Differences between healthy and affected eyes could be appreciated with all methods with different discriminatory abilities as a function of the plexus analyzed. Longitudinal monitoring of vessel density should be performed with the same algorithm. Studies adopting vessel density as an outcome measure should not rely on external normative databases.

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Optical coherence tomography angiography in pseudophakic cystoid macular oedema compared to diabetic macular oedema: qualitative and quantitative evaluation of retinal vasculature

Cited by 32 publications

References 30 publications

Cystoid macular edema related to cataract surgery and topical prostaglandin analogs: Mechanism, diagnosis, and management

Cystoid macular edema related to cataract surgery and topical prostaglandin analogs: Mechanism, diagnosis, and management

Morphofunctional analysis of the retina in patients with type 1 diabetes without complications after 30 years of disease

Comparison of methods to quantify macular and peripapillary vessel density in optical coherence tomography angiography

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