Optical coherence tomography angiography microvascular findings in macular edema due to central and branch retinal vein occlusions

Mastropasqua, Rodolfo; Toto, Lisa; Antonio, Luca Di; Borrelli, Enrico; Senatore, Alfonso; Nicola, Marta Di; G, Di Martino; Ciancaglini, Marco; Carpineto, Paolo

doi:10.1038/srep40763

Cited by 60 publications

(61 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, SSI ≥40 was used as the cut‐off threshold in the Tang et al study for evaluation of quantitative metrics in diabetic patients and the Cao et al study evaluating patients with preclinical DR. SSI ≥50 was applied in the studies reported by Samara et al, Wang et al and Seknazi et al for quantitative analysis and in the study by Iida et al for qualitative assessment of OCTA features in patients with RVO. This threshold was also used in the Hwang et al study for quantification of capillary non‐perfusion in DR. A higher threshold of SSI ≥60 was used by other studies, such as Mastropasqua et al to analyse VR in patients with RVO complicated with macular oedema, and Golebiewska et al to assess OCTA features in children with type 1 DM. Conversely, in more recent studies using Optovue device, an SQI of ≥6 was used as the threshold for acceptable images .…”

Section: Discussionmentioning

confidence: 99%

Clinical validation of the RTVue optical coherence tomography angiography image quality indicators

Ali

Sampson

Yong

et al. 2019

Clinical Exper Ophthalmology

View full text Add to dashboard Cite

Importance All automated image quality indicators for en face optical coherence tomography angiography (OCTA) images require gold standard validation for determining optimum thresholds. Background A manual grading system (gold standard) for OCTA images was validated and compared to two automated image quality indicators: signal strength index (SSI) and scan quality index (SQI) generated by different software versions of the Optovue OCTA device. Design Retrospective cross‐sectional study. Participants A total of 52 eyes of 52 healthy individual and 77 eyes of 51 patients with retinal vascular diseases. Methods A total of 129 OCTA images of the superficial vascular plexus were graded manually by three independent examiners. Each image was assigned grades 1 to 4 (1‐2, unacceptable; 3‐4, acceptable) masked to the software‐generated quality indicators. Main Outcome Measures Inter‐grader agreement and comparison of the utility of SSI and SQI in discriminating between acceptable and unacceptable OCTA images. Results There was a substantial agreement between the three graders (κ = 0.63). Mean SSI and SQI was significantly different between acceptable and unacceptable images (P < .001). SQI outperformed SSI in separating acceptable from unacceptable images (areas under the receiver operating characteristic curve: 0.87 vs 0.80) and the optimum cut‐off was ≥7 for SQI and ≥70 for SSI for acceptable images. Up to 30% of images with quality indicators reaching the optimum SQI and SSI cut‐off thresholds still had unacceptable quality on manual grading. Unacceptable images were found in 33% and 66% of healthy and diseased eyes, respectively. Conclusions and Relevance SQI is closely related to manual grading but we caution reliance on the optimized threshold to determine image quality. SQI is superior to SSI in discriminating between acceptable and unacceptable images.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical validation of the RTVue optical coherence tomography angiography image quality indicators

Ali

Sampson

Yong

et al. 2019

Clinical Exper Ophthalmology

View full text Add to dashboard Cite

show abstract

“… Non-perfusion areas (NPAs ; Figures 1 to 4 ):[ 32 ] These are also called grayish areas[ 39 ] and areas with decreased vascular perfusion. [ 6 40 ] These areas are regions without visible perfused capillaries. In RVOs, they are more extensive in the DCP than in the SCP.…”

Section: A Brief Discussion About Octamentioning

confidence: 99%

“…In RVOs, they are more extensive in the DCP than in the SCP. [ 6 10 32 33 39 40 ] These areas are more readily visible with OCTA than with FA. [ 12 ] There may be a decrease in the vascular perfusion in both the SCP and DCP of the fellow eye of RVO patients relative to normal controls, which may be a sign of previous silent RVOs in these eyes.…”

Section: A Brief Discussion About Octamentioning

confidence: 99%

“…[ 6 ] In some cases, they could be traced to the DCP. [ 6 ] The term venous-venous anastomosis by Kashani et al appears to refer to the same finding[ 10 ] Disruption of the perifoveal capillary plexus [Figures 1 – 4 ]:[ 39 40 ] The perifoveal capillary net is distorted in ischemic maculopathies including RVOs. Disruption of the FAZ is more common in the DCP than in the SCP.…”

Section: A Brief Discussion About Octamentioning

confidence: 99%

See 1 more Smart Citation

Optical coherence tomography angiography in eyes with retinal vein occlusion

Tsai¹,

Banaee²,

Conti³

et al. 2018

J Ophthalmic Vis Res

View full text Add to dashboard Cite

Optical coherence angiography (OCTA) is a noninvasive technique that has been introduced in recent years to detect ophthalmological pathology. The growing usage of OCTA to detect retinal abnormalities can be attributed to its advantages over the reference-standard fluorescein angiography (FA), although both of these techniques can be used in association. OCTA's advantages include its dye independency, its ability to produce depth-resolved images of retinal and choroidal vessels that yield images of different vascular layers of the retina, and the better delineation of the foveal avascular zone. OCTA's disadvantages include the lack of normalized patient data, artefactual projection issues, and its inability to detect low-flow lesions or pathologic conditions. Different OCTA platforms use unique algorithms to detect microvasculature, which are implemented in both spectral-domain (SD) and swept-source (SS) OCT machines. Microvascular changes in retinal vein occlusions (RVOs) are visible in both the superficial and deep capillary networks of the retina in OCTA. These visualizations include a decrease in foveal and parafoveal vascular densities, non-perfusion areas, capillary engorgement and telangiectasias, vascular tortuosity, microaneurysms, disruption of the foveal perivascular plexus, and formation of collateral vessels. The restricted field of view and inability to show leakage are important limitations associated with the use of OCTA in RVO cases. In this article, we present a brief overview of OCTA and a review of the changes detectable in different slabs by OCTA in RVO cases published in PubMed and Embase.

show abstract

“…Previous papers revealed a reduction of foveal and parafoveal retinal superficial and deep vascular density and choriocapillaris density in eyes with vein occlusion-related ME [ 33 – 35 ]. Although Mastropasqua et al found that retinal vessel plexi density did not change significantly after DEX implant and there was no correlation between vessel density and functional parameters such as visual acuity and retinal sensitivity [ 36 ], it has been demonstrated that intravitreal steroid, in eyes with macular edema due to retinal vein occlusion or diabetic retinopathy, causes a reduction of vessel diameter probably due to the blockage of VEGF [ 37 , 38 ]. Vessel occlusion may lead to functional damage of photoreceptor cells that influence visual acuity and retinal sensitivity.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Morphologic and Functional Outcomes in Macular Edema due to Central Retinal Vein Occlusion Treated with Intravitreal Dexamethasone Implant

Niro

Sborgia

et al. 2018

Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose To analyze anatomic and functional retinal changes and their correlation after intravitreal dexamethasone implant (DEX implant) in patients with central retinal vein occlusion- (CRVO-) related macular edema (ME) using optical coherence tomography and microperimetry. Methods Fifteen treatment-naïve patients with functional impairment due to CRVO-related ME were enrolled in this prospective interventional case series. Main outcomes were best-corrected visual acuity (BCVA), retinal sensitivity (RS), and central retinal thickness (CRT). Secondary outcomes were ellipsoid zone (EZ) status and fixation behaviour. All patients underwent DEX implant and were retreated according to predefined criteria. Data were prospectively recorded at baseline and at month 1, 3, 6, 9, and 12. Correlation between main outcomes was analyzed. Results Fifteen eyes of 15 patients (9 men, 6 women; mean age 61.8 ± 10.9 years) were included. BCVA and CRT significantly improved at all follow-up visits, while RS significantly improved at 3, 6, 9, and 12 months. EZ status and fixation behaviour did not change significantly. Baseline CRT had a significant negative correlation with BCVA and RS at different follow-up visits (r=−0.52 to −0.63, p ≤ 0.04; r=−0.52, p=0.04; resp.). At all time points, there was not a significant correlation between CRT and BCVA and RS, while RS and BCVA showed a significant correlation, increasing over time (r=−0.72 to −0.89; p < 0.001). Conclusion DEX implant led to a significant morphofunctional improvement. Baseline CRT is predictive of changes of functional outcomes whose correlation increases over time after treatment.

show abstract

Optical coherence tomography angiography microvascular findings in macular edema due to central and branch retinal vein occlusions

Cited by 60 publications

References 30 publications

Clinical validation of the RTVue optical coherence tomography angiography image quality indicators

Clinical validation of the RTVue optical coherence tomography angiography image quality indicators

Optical coherence tomography angiography in eyes with retinal vein occlusion

Analysis of Morphologic and Functional Outcomes in Macular Edema due to Central Retinal Vein Occlusion Treated with Intravitreal Dexamethasone Implant

Contact Info

Product

Resources

About