Optical coherence tomography as a method for quantitative skin evaluation in systemic sclerosis

Pires, Natalia S. M.; Dantas, Andréa Tavares; Duarte, Ângela Luzia Branco Pinto; Amaral, Marcello Magri; Fernandes, Luana Osório; Dias, Tereza Januária Costa; Melo, Letícia Santos Alves de; Gomes, Anderson S. L.

doi:10.1136/annrheumdis-2016-210875

Cited by 23 publications

(10 citation statements)

References 6 publications

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“…Ultrasound measurement of skin thickening is potentially a highly reliable outcome measure [ 31 ] but has not been widely adopted, probably because the equipment and training required raise feasibility issues for Phase 3 trials. Our opinion is that non‐invasive imaging techniques are likely to be a way forward at least in Phase 2 studies and that research is urgently required to validate ultrasound [ 32 ] and optical coherence tomography [ 33,34 ] as outcome measures. These non‐invasive outcome measures will complement the composite/global indices and patient‐reported outcome measures essential for later‐phase studies.…”

Section: Scleroderma (In Early Diffuse Cutaneous Ssc)mentioning

confidence: 99%

Frontiers in translational systemic sclerosis research: A focus on the unmet 'cutaneous' clinical needs (Viewpoint)

Herrick

Shukla

Watson

2020

Experimental Dermatology

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Systemic sclerosis (SSc) is a multisystem connective tissue disease associated with high morbidity and mortality: its clinical features result from a combination of fibrosis and ischaemia. Clinicians and scientists have, understandably, tended to focus on its life-threatening internal organ complications [1] which include interstitial lung disease, pulmonary hypertension, and gastro-intestinal, cardiac and renal involvement ("scleroderma renal

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Section: Scleroderma (In Early Diffuse Cutaneous Ssc)mentioning

confidence: 99%

Frontiers in translational systemic sclerosis research: A focus on the unmet 'cutaneous' clinical needs (Viewpoint)

Herrick

Shukla

Watson

2020

Experimental Dermatology

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“…Traditional OCT has a 20-year history of application in dermatology (Abignano et al, 2019b(Abignano et al, , 2017Aydin et al, 2013;Welzel et al, 1997) and has been used over the recent years as, to our knowledge, a previously unreported imaging technique able to provide a virtual biopsy of the examined skin sample in patients with SSc (Abignano andDel Galdo, 2020, 2014;Abignano et al, 2013;Kang et al, 2014;Pires et al, 2018;Ring et al, 2015;Su et al, 2015;). It uses infrared light and is able to produce sample images of micron resolution.…”

Section: Introductionmentioning

confidence: 99%

Nailfold Microvascular Imaging by Dynamic Optical Coherence Tomography in Systemic Sclerosis: A Case-Controlled Pilot Study

Abignano

Green

Eng

et al. 2022

Journal of Investigative Dermatology

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“…It is based on a Michelson interferometer, using a broadband light source to provide high spatial resolution and resolve internal structures of scattering samples . The technique has been used for imaging and analyzes over a broad number of biomedical applications . Besides its use for morphological analysis , the OCT signal has been used to determine the attenuation coefficient of biological samples for classification and diagnostic proposes .…”

Section: Introductionmentioning

confidence: 99%

General model for depth‐resolved estimation of the optical attenuation coefficients in optical coherence tomography

Amaral

Zezéll

Monte

et al. 2019

Journal of Biophotonics

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We present the proof of concept of a general model that uses the tissue sample transmittance as input to estimate the depth‐resolved attenuation coefficient of tissue samples using optical coherence tomography (OCT). This method allows us to obtain an image of tissue optical properties instead of intensity contrast, guiding diagnosis and tissues differentiation, extending its application from thick to thin samples. The performance of our method was simulated and tested with the assistance of a home built single‐layered and multilayered phantoms (~100 μm each layer) with known attenuation coefficient on the range of 0.9 to 2.32 mm−1. It is shown that the estimated depth‐resolved attenuation coefficient recovers the reference values, measured by using an integrating sphere followed by the inverse adding doubling processing technique. That was corroborated for all situations when the correct transmittance value is used with an average difference of 7%. Finally, we applied the proposed method to estimate the depth‐resolved attenuation coefficient for a thin biological sample, demonstrating the ability of our method on real OCT images.

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Optical coherence tomography as a method for quantitative skin evaluation in systemic sclerosis

Cited by 23 publications

References 6 publications

Frontiers in translational systemic sclerosis research: A focus on the unmet 'cutaneous' clinical needs (Viewpoint)

Frontiers in translational systemic sclerosis research: A focus on the unmet 'cutaneous' clinical needs (Viewpoint)

Nailfold Microvascular Imaging by Dynamic Optical Coherence Tomography in Systemic Sclerosis: A Case-Controlled Pilot Study

General model for depth‐resolved estimation of the optical attenuation coefficients in optical coherence tomography

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