Optical coherence tomography changes in macular CMV retinitis

Sun, Lei; Goodwin, Todd; Park, Joseph J.

doi:10.5693/djo.02.2012.04.001

Cited by 12 publications

(9 citation statements)

References 7 publications

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“…The results showed that the retinal atrophy caused by CMV retinitis gradually progressed, even after 2 years, and the cone photoreceptor cells were injured during the course of the disease. Our results agree with the findings of Sun et al, 5 who described the OCT changes related to CMV retinitis in the macula as a lesion involving the deeper retinal layer including the inner and outer segment junction of the photoreceptors. Because the progression of the retinal atrophy near the fovea can be directly linked to the non-reversible visual disturbance, early identification and management of the retinitis is essential.…”

supporting

confidence: 93%

“…One of the reasons why we were able to acquire such high-quality images is because the CMV retinitis occurred at the posterior pole, and although CMV retinitis often appears at the posterior pole and as peripheral retinitis the macula is rarely affected in CMV retinitis. 5 Another reason for the high-quality images might be the low inflammatory reaction in both the anterior and posterior chambers, which can cause media opacity. The low inflammatory reaction might underlie the immunosuppression induced by HIV infection.…”

mentioning

confidence: 99%

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Retinal structural features of cytomegalovirus retinitis with acquired immunodeficiency syndrome: an adaptive optics imaging and optical coherence tomography study

Shigeta

Uji

Yoshimura

2015

Clinical Exper Ophthalmology

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supporting

confidence: 93%

mentioning

confidence: 99%

Retinal structural features of cytomegalovirus retinitis with acquired immunodeficiency syndrome: an adaptive optics imaging and optical coherence tomography study

Shigeta

Uji

Yoshimura

2015

Clinical Exper Ophthalmology

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“…Consequently, intravitreal drug delivery modalities incorporating ganciclovir or foscarnet injections have emerged as alternatives, in some cases as first line if systemic infection has been ruled out (Langner-Wegscheider et al 2010;Mota et al 2011;Singh et al 2012). Intravitreal ganciclovir and foscarnet are also indicated when patients are intolerant or unresponsive to systemic therapy, and they offer introduction of a higher concentration of the drug directly to the target organ the retina (Sun et al 2012).…”

Section: Treatment and Outcomementioning

confidence: 99%

Cytomegalovirus retinitis in HIV‐negative patients – associated conditions, clinical presentation, diagnostic methods and treatment strategy

Shapira

Vishnevskia‐Dai

2017

Acta Ophthalmologica

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In recent years, numerous reports have tied cytomegalovirus retinitis (CMVR) with multiple systemic conditions in the absence of human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS). These range from reports in apparently healthy individuals, through conditions rendering limited immune dysfunction such as advanced age and diabetes mellitus, and finally severe immune dysfunction such as in haematological and rheumatological conditions. Reports are also emerging, suggesting that induced local ocular immunosuppression is a risk factor for CMVR. We herein present a comprehensive collection of the accumulated findings regarding CMVR in non-HIV patients. We summarize the spectrum of underlying morbidity that has been associated with CMVR, its clinical presentation, diagnostic methods and treatment choice in the attempt to suggest the optimal treatment strategy in this complicated and diverse patient population which is still currently lacking a consensus.

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“…The reason for the analysis was that the CMVR patients were at the early stage of CMVR when they took the OCT examination, and the ocular fundus mainly manifested in the exudation of yellowish-white particles, accompanied by retinal hemorrhage. This clinical manifestation was deemed to be retinal necrosis and different degrees of edema histologically, and significant damage [14] to the retinal structure was the most serious [15] in the active retinitis area, thereby leading to increased retinal thickness of the affected eye in the CMVR examination results. The study conducted by Invernizzi et al revealed that patients with active CMVR have 100% hemorrhage and retinal swelling.…”

Section: Discussionmentioning

confidence: 99%

A comparative study on retinal thickness of the macular region among AIDS patients with normal ocular fundus, HIV-related microvascular retinopathy patients, and cytomegalovirus retinitis patients

et al. 2019

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The present study aims to measure the retinal thickness of the macular region of AIDS patients with normal ocular fundus, HIV-related microvascular retinopathy patients and cytomegalovirus retinitis (CMVR) patients by optical coherence tomography, and generalize the characteristics of retinal thickness of these 3 groups of patients. In this retrospective case series, the study object comprised of 111 AIDS patients who received diagnosis and treatment in the Ophthalmology Department of Beijing Youan Hospital. There are 33 patients in the AIDS normal ocular fundus group, 47 patients in the HIV-related microvascular retinopathy group, and 31 patients in the CMVR group. The retinal thickness of the macular region of these above patients was measured. The main indicators were retinal thickness of 9 macular partitions, best corrected visual acuity, CD4+ T lymphocyte count, and the start of highly active antiretroviral therapy. In the CMVR group, except for the nasal-outer and temporal-outer sectors, the thickness of the affected eye of the rest of the regions was greater than that of healthy eye ( P < .05). Furthermore, there was a difference in thickness of the superior-outer and inferior-outer sectors between the AIDS normal ocular fundus group and HIV-related microvascular retinopathy group. The difference in thickness of the superior-inner sector between patients in the AIDS normal ocular fundus group and CMVR group was not statistically significant, while the difference in thickness of the rest of the regions was statistically significant. The difference in thickness of various regions between patients in the HIV-related microvascular retinopathy group and CMVR group was statistically significant. The retinal thickness of patients in the CMVR group generally increased, the retinal thickness of superior-outer and inferior-outer sections of patients in the HIV-related microvascular retinopathy group increased, when compared to the AIDS normal ocular fundus group. These optical coherence tomography (OCT) examination results present its own characteristics in different eye diseases in AIDS patients, and different stages of eye disease.

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Optical coherence tomography changes in macular CMV retinitis

Cited by 12 publications

References 7 publications

Retinal structural features of cytomegalovirus retinitis with acquired immunodeficiency syndrome: an adaptive optics imaging and optical coherence tomography study

Retinal structural features of cytomegalovirus retinitis with acquired immunodeficiency syndrome: an adaptive optics imaging and optical coherence tomography study

Cytomegalovirus retinitis in HIV‐negative patients – associated conditions, clinical presentation, diagnostic methods and treatment strategy

A comparative study on retinal thickness of the macular region among AIDS patients with normal ocular fundus, HIV-related microvascular retinopathy patients, and cytomegalovirus retinitis patients

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