Optical Coherence Tomography Findings in Patients With Retinitis Pigmentosa and Low Visual Acuity

Grigoropoulos, Vlassis; Emfietzoglou, John; Nikolaidis, Pantelis; Chatzistefanou, Klio; Vergados, J; Theodossiadis, George; Theodossiadis, Panagiotis

doi:10.3928/15428877-20091230-07

Cited by 16 publications

(10 citation statements)

References 23 publications

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“…Literature about ERM incidence in RP patients is controversial with range varying from 1 to 64% [41, 45, 46]. In our cohort the percentage of eyes with evidence of ERM ranged between 49% at baseline and 54.7% at the last follow up exam considered.…”

Section: Discussionmentioning

confidence: 87%

Comparison of 5-year progression of retinitis pigmentosa involving the posterior pole among siblings by means of SD-OCT: a retrospective study

Colombo¹,

Montesano²,

Sala³

et al. 2018

BMC Ophthalmol

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BackgroundThe aim of this study is to analyze and compare the progression of photoreceptor atrophy among siblings affected by retinitis pigmentosa by means of spectral SD-OCT.MethodsFifty three eyes of 27 patients belonging to 12 family clusters were analyzed. To assess the annual progression rate of photoreceptor atrophy, the ellipsoid zone (EZ) line was measured in OCT sections through the fovea. We used multivariate generalized mixed effects to model the rate of progression and its relation to the initial ellipsoid zone line width.ResultsDuring our 4.84 years (± 1.44) mean follow up time (range 3–7) 53 eyes were examined. The ellipsoid zone line width declined with a yearly average rate of 76.4 μm (4.16% / year) (p-value < 0.0001). Progression rates were poorly correlated within family clusters (p-value = 0.23) and showed statistical difference between affected siblings (p-value = 0.007). There was no correlation between inter-familiar progression rate and mode of inheritance (p-value = 0.98) as well as between age and ellipsoid zone line width among siblings (p-value = 0.91).ConclusionRP could be extremely heterogeneous even among siblings: an accurate and sensitive method to follow the progression of the disease is fundamental for future development of clinical trials and therapy strategies.

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Section: Discussionmentioning

confidence: 87%

Comparison of 5-year progression of retinitis pigmentosa involving the posterior pole among siblings by means of SD-OCT: a retrospective study

Colombo¹,

Montesano²,

Sala³

et al. 2018

BMC Ophthalmol

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“…ERM was present in 67% of eyes in our case series whereas, using TD-OCT, ERM had been previously classified as present in a figure variable from 1.2 to 64.3% of patients [8,12]. …”

Section: Discussionmentioning

confidence: 92%

“…These observations may suggest a multifactorial pathogenesis of RP-related CME. As previously reported, retinal edema is common to a number of genetically determined conditions in which there is degeneration of the photoreceptors and pigment epithelium and, therefore, it might be a nonspecific response to inflammation consequent upon the degeneration of photoreceptors [12]. …”

Section: Discussionmentioning

confidence: 92%

“…Previous morphological studies of TD- and SD-OCT findings in RP patients did not differentiate MPCs from CME. In particular, previous studies have reported CME from 8 to 38% of cases [8,9,11,12,16]. The presence of MPCs or CME in eyes affected by RP was not strictly associated with a well-defined ERM pulling on the foveal region, since the 55.7% of eyes with MPCs or CME showed only an ILMT.However, it is noteworthy that all the eyes presenting MPCs or CME showed a present ILMT or ERM, confirming the importance of the vitreoretinal involvement.…”

Section: Discussionmentioning

confidence: 99%

“…Optical coherence tomography (OCT) can identify vitreoretinal abnormalities associated with RP that often contribute to the deterioration of visual acuity in these patients. Previous studies conducted using time domain OCT (TD-OCT) reported a highly variable prevalence of the vitreomacular abnormalities [9,10,11,12,13]. More recently, with the advent of spectral domain OCT (SD-OCT), a range of macular abnormalities such as CME and other alterations involving the external limiting membrane (ELM) and the photoreceptor inner/outer segment (IS/OS) junction have been also described [14,15,16].…”

Section: Introductionmentioning

confidence: 99%

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Spectral Domain Optical Coherence Tomography Findings in Patients with Retinitis Pigmentosa

Triolo¹,

Pierro²,

Parodi³

et al. 2013

Ophthalmic Res

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Background: To report the morphological macular findings detected by spectral domain optical coherence tomography (SD-OCT) and to determine their prevalence in patients with retinitis pigmentosa (RP). Methods: SD-OCT scans of 176 eyes from 90 patients affected by RP were reviewed. A careful evaluation was carried out on photoreceptor inner/outer segment (IS/OS) junction, external limiting membrane (ELM), inner limiting membrane thickening (ILMT), epiretinal membranes (ERMs), retinal micropseudocysts (MPCs), cystoid macular edema (CME), macular holes (MHs) and choroidal neovascularization (CNV). Results: The photoreceptor IS/OS junction was absent in the foveal region of 24 eyes (13.6%) and disrupted in 84 eyes (47.7%). The ELM was absent in 24 eyes (13.6%), whereas the ILMT was found in 118 eyes (67%). The presence of an ERM was detected in 48 eyes (27.3%). Some sort of vitreomacular alteration (ILMT and/or ERM) was identifiable in a total of 94.3% of eyes with RP. The presence of MPCs was detected in 32 eyes (18.2%). An evident CME was found in 22 eyes (12.5%). We also found MHs in 8 eyes (4.5%) and CNV in 3 eyes (1.7%). Conclusions: Our data indicate that RP is associated with alterations of many retinal layers. In particular, the vitreoretinal interface is affected in 94% of patients, and MPC can be identified in 18% of eyes. SD-OCT may contribute to the understanding of the pathophysiological mechanism involved in RP.

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Retinal degeneration

Yoshimura¹,

Hangai²

2014

OCT Atlas

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Optical Coherence Tomography Findings in Patients With Retinitis Pigmentosa and Low Visual Acuity

Abstract: Optical coherence tomography is a more sensitive method in detecting macular pathology and can help in selecting cases where treatment may be applied.

Cited by 16 publications

References 23 publications

Comparison of 5-year progression of retinitis pigmentosa involving the posterior pole among siblings by means of SD-OCT: a retrospective study

Comparison of 5-year progression of retinitis pigmentosa involving the posterior pole among siblings by means of SD-OCT: a retrospective study

Spectral Domain Optical Coherence Tomography Findings in Patients with Retinitis Pigmentosa

Retinal degeneration

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