Optical Coherence Tomography Findings in Pre-Eclampsia: A Preliminary Receiver Operating Characteristic Analysis on Choroidal Thickness for Disease Severity

Evcimen, Yusuf; Onur, İsmail Umut; Cengiz, Hüseyin; Yigit, Fadime Ulviye

doi:10.1080/02713683.2019.1600198

Cited by 12 publications

(5 citation statements)

References 26 publications

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“…Iida et al reported that choroidal circulation appeared to be more severely affected than the retinal circulation in preeclampsia patients, and that indocyanine green angiography disclosed hyperpermeability of choroidal vessels, which suggested severe damage to choroidal vascular walls [ 8 ]. Regarding vascular hyperpermeability, Evcimen et al suggested that it is derived from a complex imbalance of choroid, involving increased hydrostatic pressure, choroidal ischemia, and endothelial cell dysfunction [ 27 ]. Garg et al demonstrated subfoveal choroidal thickening in the setting of severe preeclampsia due to rising levels of VEGF [ 9 ], and Kim et al reported that CT was increased in patients with preeclampsia and normal in healthy pregnant patients [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Relationship between the sFlt-1/PlGF ratio and the optical coherence tomographic features of chorioretina in patients with preeclampsia

2021

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This study aimed to evaluate the correlation between ophthalmologic factors and the serologic indicator soluble fms-like tyrosine kinase 1 (sFlt-1): placental growth factor (PlGF) ratio in patients with preeclampsia using optical coherence tomography (OCT) and OCT angiography (OCT-A). A total of 52 pregnant patients (104 eyes) diagnosed with preeclampsia were recruited during their hospital stay. The associations between the sFlt-1/PlGF ratio and chorioretinal measurements, including the choroidal thickness (CT), foveal avascular zone, vascular density, and ganglion cell layer+ were evaluated. Central and nasal subfield CT of the left eye (p = 0.039; p = 0.010) and nasal subfield CT of the right eye (p = 0.042) were lower in the high sFlt-1/PlGF ratio group (≥38). Pearson’s correlation test showed a negative correlation between the sFlt-1/PlGF ratio and central subfield CT; however, this was not statistically significant (p = 0.648). Linear regression analysis revealed a significant association between the sFlt-1/PlGF ratio and central subfield CT (β coefficient, -6.66; p = 0.01) and between sFlt-1 and central subfield CT (β coefficient, -5.65; p = 0.00). Thus, an increase in the sFlt-1/PlGF ratio resulted in a decrease in central subfield CT.

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Section: Discussionmentioning

confidence: 99%

Relationship between the sFlt-1/PlGF ratio and the optical coherence tomographic features of chorioretina in patients with preeclampsia

2021

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“…The choroid, which consists of fenestrated capillaries and is controlled by autonomic nerves, is sensitive to changes in PE. Previous studies have reported higher CT in pregnant women with PE than in those without it 8,17,18 . The mechanism underlying increased CT in PE is considered to be vascular endothelial cell dysfunction 18 .…”

Section: Discussionmentioning

confidence: 81%

“…Previous studies have reported higher CT in pregnant women with PE than in those without it 8,17,18 . The mechanism underlying increased CT in PE is considered to be vascular endothelial cell dysfunction 18 . However, Levine et al 19,20 reported an upregulation of anti-angiogenic proteins, such as sFlt1 and soluble endoglin, in women predisposed to developing PE.…”

Section: Discussionmentioning

confidence: 81%

Relationship between proteinuria and changes in antepartum and postpartum choroidal thickness in patients with pre-eclampsia

Lee,

Kim,

Bae

et al. 2024

Sci Rep

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Pre-eclampsia (PE) is a hypertensive disorder characterised by systemic vascular resistance and endothelial dysfunction. It is known to influence choroidal thickness (CT). No previous studies have explored the antepartum and postpartum changes in CT with respect to the protein-creatinine ratio (PCR), a measure of proteinuria that is a clinical hallmark of PE. This study evaluated the correlations between antepartum and postpartum CT and the PCR in patients with PE. In this retrospective study, sixty-six eyes (66 patients) were analysed. The patients were divided into two groups according to the median PCR value (2.36 mg/mg): low PCR group (< 2.36 mg/mg) and high PCR group (≥ 2.36 mg/mg). Ophthalmologic clinical data were collected and assessed. We observed higher antepartum CT and higher mean arterial pressure in high PCR group than in low PCR group. Moreover, postpartum CT decreased significantly in high PCR group. In the multivariate analysis, CT changes were correlated with antepartum CT and antepartum PCR after logarithm transformation. In conclusion, a greater decrease in CT was observed in high PCR group than in low PCR group. Further, the antepartum PCR showed a correlation with the extent of CT reduction.

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“…Delivery of the placenta is thus the ‘cure’ for the condition. While subfoveal choroidal thickness has been reported to be increased in PE during pregnancy, 25,26 a recent report 27 found no significant difference in the early postpartum period. This together with our own observations and Urfalıoglu's report suggest that the choroid and choriocapillaris blood flow return to normal rapidly following delivery of the placenta.…”

Section: Discussionmentioning

confidence: 95%

Correlation of Ocular Plane‐Wave Doppler With Optical Coherence Tomography Angiography in Preeclampsia

Silverman,

Urs,

Wapner

et al. 2023

J of Ultrasound Medicine

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ObjectivesPreeclampsia (PE) is a severe complication of pregnancy characterized by hypertension, proteinuria and compromised fetal blood supply. The eye, like other end organs, is affected by this systemic condition, but unlike in other organs, ocular media transparency allows high‐resolution optical visualization of the vascular structure of the retina. Our aim was to assess how ultrasound‐determined ocular blood‐flow correlates with vascular structure of the retina and choriocapillaris determined by optical coherence tomography angiography (OCTA).MethodsPlane‐wave ultrasound and OCTA were performed on both eyes of 40 consecutive subjects consisting of normal controls (n = 11), mild PE (n = 5), severe PE (n = 17) and chronic or gestational hypertension (n = 7) within 72 hours following delivery. From ultrasound, we measured pulsatile flow velocity and resistance indices in the central retinal artery (CRA) and vein, the short posterior ciliary arteries (SPCAs) and choroid. From OCTA, we measured vascular density (VD) in the superficial, deep retina and choriocapillaris. We determined differences in Doppler and OCTA parameters among groups and correlations between ultrasound and OCTA.ResultsIn severe PE, flow resistance was reduced with respect to controls. Flow velocity and resistance in the and SPCA were moderately correlated with VD in the choriocapillaris and peripapillary retina, but VD in PE did not differ significantly from controls.ConclusionsAlthough OCTA parameters were moderately correlated with Doppler ultrasound, OCTA did not demonstrate significant differences between PE and controls postpartum.

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Optical Coherence Tomography Findings in Pre-Eclampsia: A Preliminary Receiver Operating Characteristic Analysis on Choroidal Thickness for Disease Severity

Cited by 12 publications

References 26 publications

Relationship between the sFlt-1/PlGF ratio and the optical coherence tomographic features of chorioretina in patients with preeclampsia

Relationship between the sFlt-1/PlGF ratio and the optical coherence tomographic features of chorioretina in patients with preeclampsia

Relationship between proteinuria and changes in antepartum and postpartum choroidal thickness in patients with pre-eclampsia

Correlation of Ocular Plane‐Wave Doppler With Optical Coherence Tomography Angiography in Preeclampsia

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