Optical coherence tomography for diagnosing skin cancer in adults

Abstract

Background Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high-risk skin cancers, which have the potential to metastasise and ultimately lead to death, whereas basal cell carcinoma (BCC) is usually localised, with potential to infiltrate and damage surrounding tissue. Anxiety around missing early cases needs to be balanced against inappropriate referral and unnecessary excision of benign lesions. Optical coherence tomography (OCT) is a microscopic imaging technique, which magnifies the surface of a skin lesion using near-infrared light. Used in conjunction with clinical or dermoscopic examination of suspected skin cancer, or both, OCT may offer additional diagnostic information compared to other technologies. Objectives To determine the diagnostic accuracy of OCT for the detection of cutaneous invasive melanoma and atypical intraepidermal melanocytic variants, basal cell carcinoma (BCC), or cutaneous squamous cell carcinoma (cSCC) in adults.

Use of Optical Coherence Tomography (OCT) in Aesthetic Skin Assessment—A Short Review

“…The OCT device in combination with reflectance confocal microscopy imaging has shown great sensitivity and specificity to detect BCC [10,11]. A recent study reported the sensitivity and specificity of the OCT devices' ability to detect BCC to be 95% and 77%, respectively [12]. The same capabilities are also used for defining pathologic skin margins prior to surgery and monitoring the skin progress following non‐invasive treatments [13–16].…”

Trends analysis of cancer topic of Cochrane systematic reviews: a bibliometric analysis

“…The rest top 10 co-cited references including methodology studies (20,25) , epidemiological data of cancer (24) , and the reporting guideline of systematic reviews (26) . The latest co-cited references were focused on the diagnosis and treatment of skin cancer in adults (43)(44)(45) . All these co-cited references constituted the knowledge base of this field.…”

“…For example, the differentiation of melanocytes from langerhans cells in melanocytic lesions lacks specificity, the misdiagnosis due to specific lesion or missed detection because of sampling error, as well as the clinical experience of the doctors (63) . There were four records in Cancer-CSR concentrated on the applying of RCM for diagnosing skin cancer in adults with any suspicious lesion which was all published in 2018 (64)(65)(66)(67) .…”

Detecting mouse squamous cell carcinoma from submicron full‐field optical coherence tomography images by deep learning

“…7 However, many review papers manifest the lack of study in cutaneous SCC. [8][9][10] In this work, we focus on SCC detection.…”