Optical coherence tomography for identifying unstable coronary plaque

Brezinski, Mark E.

doi:10.1016/j.ijcard.2005.07.066

Cited by 42 publications

(32 citation statements)

References 55 publications

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“…OCT is an interferometry technique using broadband near-infrared (NIR) light beyond 800 nm. It enables non-invasive and label-free real-time three-dimensional imaging [22,53,54] and relatively deep penetration into tissues (up to 2000 mm) compared with other visible or NIR light techniques ( [39]; table 1). In relation to MRI and mCT, penetration is low; however, what makes OCT strong is that it resolves structures almost at the cellular range.…”

Section: Imaging Techniques In the Scaffold Design And Developmentmentioning

confidence: 99%

“…Some studies applied OCT for three-dimensional characterization of polylactate and chitosan scaffolds. In other research work, cell behaviour, kinetics of cell invasion into collagen gels and three-dimensional cell models were studied with OCT ( figure 1c(II)) [25,53,54]. By observing the calcification process in the gelatine gels, OCT proved useful to mimic bone regeneration [23,42,49,[55][56][57].…”

Section: Imaging Techniques In the Scaffold Design And Developmentmentioning

confidence: 99%

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Taking a deep look: modern microscopy technologies to optimize the design and functionality of biocompatible scaffolds for tissue engineering in regenerative medicine

Vielreicher

Schürmann

Detsch

et al. 2013

J. R. Soc. Interface.

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This review focuses on modern nonlinear optical microscopy (NLOM) methods that are increasingly being used in the field of tissue engineering (TE) to image tissue non-invasively and without labelling in depths unreached by conventional microscopy techniques. With NLOM techniques, biomaterial matrices, cultured cells and their produced extracellular matrix may be visualized with high resolution. After introducing classical imaging methodologies such as µCT, MRI, optical coherence tomography, electron microscopy and conventional microscopy two-photon fluorescence (2-PF) and second harmonic generation (SHG) imaging are described in detail (principle, power, limitations) together with their most widely used TE applications. Besides our own cell encapsulation, cell printing and collagen scaffolding systems and their NLOM imaging the most current research articles will be reviewed. These cover imaging of autofluorescence and fluorescence-labelled tissue and biomaterial structures, SHG-based quantitative morphometry of collagen I and other proteins, imaging of vascularization and online monitoring techniques in TE. Finally, some insight is given into state-of-the-art three-photon-based imaging methods (e.g. coherent anti-Stokes Raman scattering, third harmonic generation). This review provides an overview of the powerful and constantly evolving field of multiphoton microscopy, which is a powerful and indispensable tool for the development of artificial tissues in regenerative medicine and which is likely to gain importance also as a means for general diagnostic medical imaging.

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Section: Imaging Techniques In the Scaffold Design And Developmentmentioning

confidence: 99%

Section: Imaging Techniques In the Scaffold Design And Developmentmentioning

confidence: 99%

Taking a deep look: modern microscopy technologies to optimize the design and functionality of biocompatible scaffolds for tissue engineering in regenerative medicine

Vielreicher

Schürmann

Detsch

et al. 2013

J. R. Soc. Interface.

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show abstract

“…With an axial resolution of approximately 10 µm, OCT provides an order of magnitude resolution improvement with a greater dynamic range as compared to commercially available intravascular ultrasound systems. 1,2 The major trade-off accompanying these benefits is the smaller depth of penetration; OCT can image approximately 1 to 2 mm beneath the surface of typical tissues.…”

Section: Optical Coherence Tomography In Vascular Imagingmentioning

confidence: 99%

Assessment of blood vessel mimics with optical coherence tomography

et al. 2007

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Optical coherence tomography (OCT) is an imaging modality that enables assessment of tissue structural characteristics. Studies have indicated that OCT is a useful method to assess both blood vessel morphology and the response of a vessel to a deployed stent. We evaluated the ability of OCT to visualize the cellular lining of a tissue-engineered blood vessel mimic (BVM) and the response of this lining to a bare metal stent. We develop a side-firing endoscope that obtains intraluminal, longitudinal scans within the sterile bioreactor environment, enabling time-serial assessment. Seventeen BVMs are imaged with the endoscopic OCT system. The BVMs are then evaluated via fluorescence microscopy and/or standard histologic techniques. We determine that (1) the OCT endoscope can be repeatedly inserted without visible damage to the BVM cellular lining, (2) OCT provides a precise measure of cellular lining thickness with good correlation to measurements obtained from histological sections, and (3) OCT is capable of monitoring the accumulation of cellular material in response to a metallic stent. Our studies indicate that OCT is a useful technique for monitoring the BVM cellular lining, and that OCT may facilitate the use of BVMs for early stage device assessment.

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“…OCT is well established in the field of ophthalmology (retinal imaging) [81,82] and is emerging as a diagnostic tool in cardiology and gastroenterology [79,[83][84][85][86][87]. Its current use in the respiratory system is limited: research to date has focused on detection of dysplastic and neoplastic epithelial changes.…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

Quantifying tracheobronchial tree dimensions: methods, limitations and emerging techniques

Williamson¹,

James²,

Phillips³

et al. 2009

Eur Respir J

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The ability to measure airway dimensions is important for clinicians, interventional bronchoscopists and researchers in order to accurately quantify structural abnormalities and track their changes over time or in response to treatment.Most quantitative airway measurements are based on X-ray computed tomography and, more recently, on multidetector computed tomography. Quantitative bronchoscopic techniques have also been developed, although these are less widely employed. Emerging techniques, including magnetic resonance imaging, endoscopic optical coherence tomography, endobronchial ultrasound and confocal endomicroscopy, provide new research tools with potential clinical applications.An understanding of issues related to the acquisition, processing and analysis of images, and how such issues impact on imaging the tracheobronchial tree, is essential in order to assess measurement accuracy and to make effective use of the newer methods. This article contributes to this understanding by providing a comprehensive review of current and emerging techniques for quantifying airway dimensions.KEYWORDS: Airway dimensions, confocal endomicroscopy, multidetector computed tomography, optical coherence tomography, videobronchoscopy A dvances over the past 20 yrs in medical imaging and bronchoscopy have heralded an era of unprecedented access to quantitative information on tracheobronchial structure and, increasingly, function. The expanding scope of technical advances challenges the ability of clinicians and researchers to keep abreast of recent developments and emerging techniques. Computed tomography (CT) and, to a lesser extent, bronchoscopy are the two imaging tools that have contributed most to our understanding of the airway in vivo and are used on a daily basis by clinicians in the management of airway diseases. Newer techniques, such as magnetic resonance imaging, optical coherence tomography, fibreoptic confocal endomicroscopy and endobronchial ultrasound, offer fresh insights into the way we view and quantify the airway.Over the coming years, the clinical applications of these newer techniques will be defined. As with endobronchial ultrasound, which has been adopted by interventional bronchoscopists in a little over a decade from its first reported use [1], it is likely that smoking-related lung diseases, such as bronchogenic cancer and chronic obstructive pulmonary disease (COPD), will drive the rapid development of new endoscopic imaging modalities and maintain the current pace of technical improvements of existing techniques, in particular CT. Initial applications of these techniques may focus on screening and surveillance of endobronchial malignancies and the use of real-time airway measurements during interventional procedures to deploy endobronchial stents. In these settings, accurate real-time quantitative imaging is advantageous.

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Optical coherence tomography for identifying unstable coronary plaque

Cited by 42 publications

References 55 publications

Taking a deep look: modern microscopy technologies to optimize the design and functionality of biocompatible scaffolds for tissue engineering in regenerative medicine

Taking a deep look: modern microscopy technologies to optimize the design and functionality of biocompatible scaffolds for tissue engineering in regenerative medicine

Assessment of blood vessel mimics with optical coherence tomography

Quantifying tracheobronchial tree dimensions: methods, limitations and emerging techniques

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