Optical coherence tomography for precision brain imaging, neurosurgical guidance and minimally invasive theranostics

Fan, Yingwei; Xia, Yan; Zhang, Xinran; Sun, Yu; Tang, Jie; Zhang, Liwei; Liao, Hongen

doi:10.5582/bst.2017.01258

Cited by 42 publications

(27 citation statements)

References 103 publications

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“…2 In recent decades, a number of studies have shown the promising results of using OCT in the assessment of health and disease in brain tissue (including glial brain tumors). 3,4 Recently, OCT has been integrated into operating microscopes for neurological surgery. 5,6 As for structural OCT, time-domain OCT 7,8 and swept-source OCT 9,10 have been used for the detection of brain tumor margins.…”

Section: Introductionmentioning

confidence: 99%

Optical coefficients as tools for increasing the optical coherence tomography contrast for normal brain visualization and glioblastoma detection

et al. 2019

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Section: Introductionmentioning

confidence: 99%

Optical coefficients as tools for increasing the optical coherence tomography contrast for normal brain visualization and glioblastoma detection

et al. 2019

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“…Both structural and functional information about the specimen can be extracted from the OCT signal. [123][124][125][126][127][128] There are two major types of OCT systems commercially available on the market: SD and swept-source (SS). SDOCT is based on a broadband light source, typically super luminescent diode (SLD) and spectroscopic device to perform parallel (relative to wave-number) detection of the interference signal in a frequency domain.…”

Section: Optical Coherence Tomography For In Vivo Imaging Of Meningeamentioning

confidence: 99%

“…The lymphatic vessel is marked by an arrow; blood vessel is marked by the white rectangle. Micro-angiography techniques became the most popular methods for blood vessels mapping in OCT. 126,136 Unlike Doppler protocols 125 they are angle free, robust and easy to implement. In general, they are based on the analysis of the time-variant intensity of speckle structures, produced by a moving RBCs within the vessel.…”

Section: Oct Analysis Of Cerebral Blood Flow and Lymphatic Drainage Imentioning

confidence: 99%

Photodynamic therapy of brain tumors and novel optical coherence tomography strategies for in vivo monitoring of cerebral fluid dynamics

Abdurashitov

Tuchin

Semyachkina-Glushkovskaya

2020

J. Innov. Opt. Health Sci.

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Photodynamic therapy (PDT) is a promising tool for least-invasive alternative methods for the treatment of brain tumors. The newly discovered PDT-induced opening of the blood–brain barrier (BBB) permeability open novel strategies for drug-brain delivery during post-surgical treatment of glioblastoma GBM. Here we discuss mechanisms of PDT-mediated opening of the BBB and age differences in PDT-related increase in BBB permeability, including with formation of brain edema. The meningeal lymphatic system plays a crucial role in the mechanism of brain drainage and clearance from metabolites and toxic molecules. We discuss that noninvasive photonic stimulation of fluid clearance via meningeal lymphatic vessels, and application of optical coherence tomography (OCT) for bed-side monitoring of meningeal lymphatic drainage has the promising perspective to be widely applied in both experimental and clinical studies of PDT and improving guidelines of PDT of brain tumors.

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“…Laser ablation can be used in minimally invasive surgery for diseased tissue. Intraoperative laser ablation has been proposed for neurosurgical resection, and the results of laser ablation have been evaluated and compared to those of neurosurgical resection 4 , 5 . As a new tool, laser ablation is used as an alternative surgery for brain tumors 6 .…”

Section: Introductionmentioning

confidence: 99%

“…Stereotactic laser ablation has also been used in the focal treatment of high-grade glioma 7 and recurrent high-grade glioma 6 , 8 . Advances in probe design, cooling mechanisms, and intraoperative imaging and real-time diagnosis have increased the utilization of lasers in neurosurgical treatment 5 , 9 . In vivo laser ablation of mouse brain tumors has been implemented 10 .…”

Section: Introductionmentioning

confidence: 99%

Bioluminescence imaging and two-photon microscopy guided laser ablation of GBM decreases tumor burden

et al. 2018

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Brain tumor delineation and treatment are the main concerns of neurosurgeons in neurosurgical operations. Bridging the gap between imaging/diagnosis and treatment will provide great convenience for neurosurgeons. Here, we developed an optical theranostics platform that helps to delineate the boundary and quantitatively analyze glioblastoma multiforms (GBMs) with bioluminescence imaging (BLI) to guide laser ablation, and we imaged the GBM cells with two-photon microscopy (TPM) to visualize the laser ablation zone in vivo.Methods: Laser ablation, using the method of coupled ablated path planning with the guidance of BLI, was implemented in vivo for mouse brain tumors. The mapping relationship between semi-quantitative BLI and the laser ablation path was built through the quantitative tumor burden. The mapping was reflected through coupled ablated path planning. The BLI quantitatively and qualitatively evaluated treatment using laser ablation with the appropriate laser parameters and laser-tissue parameters. These parameters were measured after treatment. Furthermore, histopathological analysis of the brain tissue was conducted to compare the TPM images before and after laser ablation and to evaluate the results of in vivo laser ablation. The local recurrences were measured with three separate cohorts. The weights of all of the mice were measured during the experiment.Results: Our in vivo BLI data show that the tumor cell numbers were significantly attenuated after treatment with the optical theranostics platform, and the delineation of GBM margins had clear views to guide the laser resection; the fluorescence intensity in vivo of GBMs quantitatively analyzed the rapid progression of GBMs. The laser-tissue parameters under guidance of multimodality imaging ranged between 1.0 mm and 0.1 mm. The accuracy of the laser ablation reached a submillimeter level, and the resection ratio reached more than 99% under the guidance of BLI. The histopathological sections were compared to TPM images, and the results demonstrated that these images highly coincided. The weight index and local recurrence results demonstrated that the therapeutic effect of the optical theranostics platform was significant.Conclusion: We propose an optical multimodality imaging-guided laser ablation theranostics platform for the treatment of GBMs in an intravital mouse model. The experimental results demonstrated that the integration of multimodality imaging can precisely guide laser ablation for the treatment of GBMs. This preclinical research provides a possibility for the precision treatment of GBMs. The study also provides some theoretical support for clinical research.

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Optical coherence tomography for precision brain imaging, neurosurgical guidance and minimally invasive theranostics

Cited by 42 publications

References 103 publications

Optical coefficients as tools for increasing the optical coherence tomography contrast for normal brain visualization and glioblastoma detection

Optical coefficients as tools for increasing the optical coherence tomography contrast for normal brain visualization and glioblastoma detection

Photodynamic therapy of brain tumors and novel optical coherence tomography strategies for in vivo monitoring of cerebral fluid dynamics

Bioluminescence imaging and two-photon microscopy guided laser ablation of GBM decreases tumor burden

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