Optical coherence tomography imaging in keratoconus

Yip, Harry; Chan, Elsie

doi:10.1111/cxo.12874

Cited by 21 publications

(16 citation statements)

References 72 publications

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“…High-resolution OCT imaging was shown to be useful to understand the intracorneal changes following ectatic disorders and in patients that have undergone refractive surgery 25 . Epithelial thinning at the corneal apex associated with epithelial thickening in the area around the apex was observed to be characteristic features in keratoconic patients in histological and in-vivo imaging, such as very high-frequency ultrasound, studies 26 .…”

Section: Discussionmentioning

confidence: 99%

Epithelial and stromal remodelling following femtosecond laser–assisted stromal lenticule addition keratoplasty (SLAK) for keratoconus

Nubile

Salgari

Calienno

et al. 2021

Sci Rep

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The purpose of this study was to evaluate corneal epithelium and stromal remodelling with anterior segment optical coherence tomography in patients who have undergone stromal lenticule addition keratoplasty (SLAK) for advanced keratoconus. This was a prospective non-comparative observational study. Fifteen eyes of 15 patients with advanced keratoconus underwent implantation with a cadaveric, donor negative meniscus-shaped intrastromal lenticule, produced with a femtosecond laser, into a stromal pocket dissected in the recipient cornea at a depth of 120 μm. Simulated keratometry, central corneal thickness (CTT), corneal thinnest point (CTP), central epithelial thickness (CET), central and peripheral lenticule thickness, anterior and posterior stromal thickness were measured. Regional central corneal epithelial thickness (CET) and variations in the inner annular area (IAT) and outer annular area (OAT) were also analysed. All parameters were measured preoperatively and 1, 3, and 6 months postoperatively. The average anterior Sim-k decreased from 59.63 ± 7.58 preoperatively to 57.19 ± 6.33 D 6 months postoperatively. CCT, CTP, CET, and OAT increased and IAT decreased significantly after 1 month. All parameters appeared unchanged at 6-months except that of OAT that further increased. Lenticule thickness was stable. In conclusion we observed that SLAK reshapes the cornea by central flattening with stromal thickening and epithelial thickness restoration.

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Section: Discussionmentioning

confidence: 99%

Epithelial and stromal remodelling following femtosecond laser–assisted stromal lenticule addition keratoplasty (SLAK) for keratoconus

Nubile

Salgari

Calienno

et al. 2021

Sci Rep

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“…However, OCT can obtain threedimensional imaging of the sub-surface of the eyeball structure with the micron spatial resolution and with millisecond time resolution [41,44], which can observe the pathological alterations of the ocular fundus and provide supplemental information to monitor the progress of the disease accurately and further understanding of the blindness. There is no doubt that ophthalmology is the most widely used application of OCT. OCT has been a standard detection tool in ophthalmology clinics and significantly improves the potential of early diagnosis, monitoring, and precise treatment [33,45]. The representative OCT image of the mouse retina is shown in Figure 5A, which indicates that OCT can image the layers of the retina clearly, thereby providing corresponding structural information for retinal diseases.…”

Section: Applications Of Optical Coherence Tomography In the Biomedical Field Optical Coherence Tomography In Ophthalmologymentioning

confidence: 99%

Optical Coherence Tomography for Three-Dimensional Imaging in the Biomedical Field: A Review

et al. 2021

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Optical coherence tomography (OCT) has become a novel approach to noninvasive imaging in the past three decades, bringing a significant potential to biological research and medical biopsy in situ, particularly in three-dimensional (3D) in vivo conditions. Specifically, OCT systems using broad bandwidth sources, mainly centered at near-infrared-II, allow significantly higher imaging depth, as well as maintain a high-resolution and better signal-to-noise ratio than the traditional microscope, which avoids the scattering blur and thus obtains more details from delicate biological structures not just limited to the surface. Furthermore, OCT systems combined the spectrometer with novel light sources, such as multiplexed superluminescent diodes or ultra-broadband supercontinuum laser sources, to obtain sub-micron resolution imaging with high-speed achieve widespread clinical applications. Besides improving OCT performance, the functional extensions of OCT with other designs and instrumentations, taking polarization state or birefringence into account, have further improved OCT properties and functions. We summarized the conventional principle of OCT systems, including time-domain OCT, Fourier-domain OCT, and several typical OCT extensions, compared their different components and properties, and analyzed factors that affect OCT performance. We also reviewed current applications of OCT in the biomedical field, especially in hearing science, discussed existing limitations and challenges, and looked forward to future development, which may provide a guideline for those with 3D in vivo imaging desires.

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“…При этом ОКТ-пахиметрия является более точным методом выявления первичной КЭ на субклинической стадии, что особенно важно для пациентов, которым планируется проведение операции LASIK, ФРК и др. [33]. Ретроспективный анализ ОКТ глаз пациентов с диагнозом «кератоконус развитой стадии» показал, что такие изменения роговицы, как выраженное истончение эпителия и стромы на вершине конуса, участки боуменовой мембраны с повышенной отражающей способностью и отсутствие признаков рубцевания стромы, являются предикторами развития острого кератоконуса [34].…”

Section: окт в диагностике заболеваний роговицыunclassified

Optical Coherence Tomography for Diagnosis and Treatment of Corneal Diseases

Fisenko¹,

Osipyan²

2021

Oftalʹmologiâ

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Optical coherence tomography (OCT) is a modern non-contact real-time imaging of anterior and posterior eye’s segments. Based on the principle of low-coherence interferometry, it provides the analysis of tissue structures. In this review, we discuss technical aspects of two different OCT platforms: Time-Domain OCT (TD-OCT), and Spectral-Domain (SD-OCT) with the use of Fourier transformation — Fourier-Domain (FD-OCT). Over the last several years, the development of OCT has increased the resolution of images by different ways of optical filtering. The usage of tunable swept laser instead of superluminescent diode in modern Swept-Source OCT (SS-OCT) provides the sufficient quality of image. Anterior segment OCT can detect the pathological changes in different ocular structures and may be a key tool for monitoring of their progression. In pterygium OCT shows the true extent of fibrovascular granulation tissue in stromal layers, whereas in keratitis it provides imaging of corneal infiltration. Frequently, OCT-pachymetry can be advantageous in the detection of subclinical keratectasias. In patients with bullous keratopathy OCT can help to distinguish corneal edema and fibrosis. The new era of OCT is characterized by application of this method in keratorefractive surgery. Microscope-mounted (portable) and microscopeintegrated OCT systems have been developed. During LASIK surgery intraoperative OCT (iOCT) helps to assess flap interface, measure flap and residual bed thickness. It is a useful tool to reveal the structural changes during corneal collagen crosslinking. At the beginning of keratoplasty, iOCT helps to determine the corneal thickness, extent and depth of opacity, Descemet membrane perforation. iOCT guides decision-making regarding keratoplasty modification, depth and diameter of trephination. Furthermore, a real-time visualization of ocular structures during keratoplasty decreases the frequency of intra- and postsurgical complications.

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Optical coherence tomography imaging in keratoconus

Cited by 21 publications

References 72 publications

Epithelial and stromal remodelling following femtosecond laser–assisted stromal lenticule addition keratoplasty (SLAK) for keratoconus

Epithelial and stromal remodelling following femtosecond laser–assisted stromal lenticule addition keratoplasty (SLAK) for keratoconus

Optical Coherence Tomography for Three-Dimensional Imaging in the Biomedical Field: A Review

Optical Coherence Tomography for Diagnosis and Treatment of Corneal Diseases

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