Optical Coherence Tomography in a Needle Format

Lorenser, Dirk; McLaughlin, Robert A.; Sampson, David D.

doi:10.1007/978-3-319-06419-2_83

Cited by 6 publications

(7 citation statements)

References 114 publications

(270 reference statements)

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“…OCT is highly versatile, being deployed for imaging the inner walls of blood vessels and luminal organs, 252 – 256 having an ultrawide field of view for scanning skin, 257 – 259 and with corrective lenses, compensating for ocular refraction in the ophthalmologic clinic. Nonetheless, there are several fundamental issues that are limiting its general adoption.…”

Section: Depth-resolved Imagingmentioning

confidence: 99%

“…For this reason, large-scale clinical deployment of OCT has largely been limited to ophthalmology, dermatology, and cardiology, but creative advances in OCT probe and capsule technology will allow for continued in situ exploration of hemoglobin-related biomarkers from OCT in disease pathology throughout the body. 256 , 260 – 262 …”

Section: Depth-resolved Imagingmentioning

confidence: 99%

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Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis

et al. 2022

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. Significance: Measurement and imaging of hemoglobin oxygenation are used extensively in the detection and diagnosis of disease; however, the applied instruments vary widely in their depth of imaging, spatiotemporal resolution, sensitivity, accuracy, complexity, physical size, and cost. The wide variation in available instrumentation can make it challenging for end users to select the appropriate tools for their application and to understand the relative limitations of different methods. Aim: We aim to provide a systematic overview of the field of hemoglobin imaging and sensing. Approach: We reviewed the sensing and imaging methods used to analyze hemoglobin oxygenation, including pulse oximetry, spectral reflectance imaging, diffuse optical imaging, spectroscopic optical coherence tomography, photoacoustic imaging, and diffuse correlation spectroscopy. Results: We compared and contrasted the ability of different methods to determine hemoglobin biomarkers such as oxygenation while considering factors that influence their practical application. Conclusions: We highlight key limitations in the current state-of-the-art and make suggestions for routes to advance the clinical use and interpretation of hemoglobin oxygenation information.

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Section: Depth-resolved Imagingmentioning

confidence: 99%

Section: Depth-resolved Imagingmentioning

confidence: 99%

Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis

et al. 2022

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“…This system implements a manual-balancing variant of balanced detection, as described in Ref. 25. Unlike some other approaches to balanced detection, this scheme may be utilized for both dual-arm and common-path OCT probes.…”

Section: Dual-modality Imaging Systemmentioning

confidence: 99%

Multimodal imaging needle combining optical coherence tomography and fluorescence for imaging of live breast cancer cells labeled with a fluorescent analog of tamoxifen

et al. 2022

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Significance: Imaging needles consist of highly miniaturized focusing optics encased within a hypodermic needle. The needles may be inserted tens of millimeters into tissue and have the potential to visualize diseased cells well beyond the penetration depth of optical techniques applied externally. Multimodal imaging needles acquire multiple types of optical signals to differentiate cell types. However, their use has not previously been demonstrated with live cells.Aim: We demonstrate the ability of a multimodal imaging needle to differentiate cell types through simultaneous optical coherence tomography (OCT) and fluorescence imaging.Approach: We characterize the performance of a multimodal imaging needle. This is paired with a fluorescent analog of the therapeutic drug, tamoxifen, which enables cell-specific fluorescent labeling of estrogen receptor-positive (ER+) breast cancer cells. We perform simultaneous OCT and fluorescence in situ imaging on MCF-7 ER+ breast cancer cells and MDA-MB-231 ER− cells. Images are compared against unlabeled control samples and correlated with standard confocal microscopy images.Results: We establish the feasibility of imaging live cells with these miniaturized imaging probes by showing clear differentiation between cancerous cells.Conclusions: Imaging needles have the potential to aid in the detection of specific cancer cells within solid tissue.

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“…In addition, fiber optic probes have been even successfully integrated within a single medical needle. 19 However, conventional probes still require additional optical elements for beam focusing or beam deflection such as prism, mirror, or objective lens. The optical elements require precise optical alignments and large packaging size.…”

Section: Introductionmentioning

confidence: 99%

Objective-lens-free confocal endomicroscope using Lissajous scanning lensed-fiber

Kim

Hwang

Jeong

2021

J. Optical Microsystems

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We report an objective-lens-free endomicroscopic catheter for compact Lissajous scanned confocal endomicroscopic system using a scanning lensed-fiber. The fiber scanner comprises a single-mode fiber (SMF) spliced with a coreless silica fiber segment and quadrupole piezoelectric tube. An objective lens was directly formed at the distal end of an SMF using a fusion splicer. The lensed fiber eliminates the need for conventional beam focusing elements such as a gradient index rod lens and precise optical alignment, allowing low cost and facile fabrication of an exceptionally short endomicroscopic catheter. The endomicroscopic scanner was fully packaged within a stainless tube of 2.6 mm in outer diameter and 20 mm in length, which can be easily inserted through the working channel of conventional laparoscope or colonoscope. The microscopic images of a stained kidney section and ear of a mouse were successfully obtained with the Lissajous scanning confocal endomicroscope. The compact Lissajous scanning lensed fiber can provide a new route for diverse in vivo endomicroscopic applications. © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Optical Coherence Tomography in a Needle Format

Cited by 6 publications

References 114 publications

Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis

Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis

Multimodal imaging needle combining optical coherence tomography and fluorescence for imaging of live breast cancer cells labeled with a fluorescent analog of tamoxifen

Objective-lens-free confocal endomicroscope using Lissajous scanning lensed-fiber

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