Optical coherence tomography in gastroenterology: a review and future outlook

Tsai, Tsung Han; Leggett, Cadman L.; Trindade, Arvind J.; Sethi, Amrita; Swager, Anne Fré; Joshi, Virendra; Bergman, Jacques; Mashimo, Hiroshi; Nishioka, Norman S.; Namati, Eman

doi:10.1117/1.jbo.22.12.121716

Cited by 70 publications

(55 citation statements)

References 161 publications

(174 reference statements)

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“…OCT technology is thus capable of obtaining deeper images with similar resolution compared with currently available confocal endomicroscopy, but without the need for intravenous contrast agents that may extravasate and obscure visualization during biopsies or endoscopic mucosal resection (EMR). Moreover, unlike confocal endomicroscopy, OCT allows visualization of a large surface area or even the entire esophagus . This is of particular importance since dysplasia often arises as small and scattered lesions within BE and current random biopsies using the Seattle protocol assess less than 3% of the BE surface.…”

Section: Surveillancementioning

confidence: 99%

“…Moreover, unlike confocal endomicroscopy, OCT allows visualization of a large surface area or even the entire esophagus. 46 This is of particular importance since dysplasia often arises as small and scattered lesions within BE and current random biopsies using the Seattle protocol assess less than 3% of the BE surface. As such, OCT is uniquely poised for both pre and postablative assessment in BE.…”

Section: Surveillancementioning

confidence: 99%

See 1 more Smart Citation

Recent advances in Barrett's esophagus

Inadomi

Alastal

Bonavina

et al. 2018

Annals of the New York Academy of Sciences

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Barrett's esophagus (BE) is the only known precursor of esophageal adenocarcinoma, one of the few cancers with increasing incidence in developed countries. The pathogenesis of BE is unclear with regard to either the cellular origin of this metaplastic epithelium or the manner in which malignant transformation occurs, although recent data indicate a possible junctional origin of stem cells for BE. Treatment of BE may be achieved using endoscopic eradication therapy; however, there is a lack of discriminatory tools to identify individuals at sufficient risk for cancer development in whom intervention is warranted. Reduction in gastroesophageal reflux of gastric contents including acid is mandatory to achieve remission from BE after endoscopic ablation, and can be achieved using medical or nonmedical interventions. Research topics of greatest interest include the mechanism of BE development and transformation to cancer, risk stratification methods to identify individuals who may benefit from ablation of BE, optimization of eradication therapy, and surveillance methods to ensure that remission is maintained after eradication is achieved.

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Section: Surveillancementioning

confidence: 99%

Section: Surveillancementioning

confidence: 99%

Recent advances in Barrett's esophagus

Inadomi

Alastal

Bonavina

et al. 2018

Annals of the New York Academy of Sciences

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“…On the other hand, subsurface imaging, which includes endoscopic ultrasonography [10], confocal endomicroscopy [11], and OCT, allows for visualization of structures not feasible with most endoscopes. microscopic resolution with volumetric and subsurface real-time imaging capabilities [12]. These characteristics position OCT to solve many of the weaknesses of the other GI tract imaging techniques.…”

Section: Introductionmentioning

confidence: 99%

“…These characteristics position OCT to solve many of the weaknesses of the other GI tract imaging techniques. This review will explore some of the recent advances of OCT in GI applications and describe the future potential for OCT to incorporate purpose-build probe designs and computeraided diagnosis techniques [12].…”

Section: Introductionmentioning

confidence: 99%

Application of OCT in the Gastrointestinal Tract

Samel

Mashimo

2019

Applied Sciences

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Optical coherence tomography (OCT) is uniquely poised for advanced imaging in the gastrointestinal (GI) tract as it allows real-time, subsurface and wide-field evaluation at near-microscopic resolution, which may improve the current limitations or even obviate the need of superficial random biopsies in the surveillance of early neoplasias in the near future. OCT’s greatest impact so far in the GI tract has been in the study of the tubular esophagus owing to its accessibility, less bends and folds and allowance of balloon employment with optimal contact to aid circumferential imaging. Moreover, given the alarming rise in the incidence of Barrett’s esophagus and its progression to adenocarcinoma in the U.S., OCT has helped identify pathological features that may guide future therapy and follow-up strategy. This review will explore the current uses of OCT in the gastrointestinal tract and future directions, particularly with non-endoscopic office-based capsule OCT and the use of artificial intelligence to aid in diagnoses.

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“…To date, no studies have been performed on the use of CADx in conjunction with capsule modalities other than WLI 1 because of the limited number of non-WLI CE devices available. However, initial studies on the use of CADx with 2 non-capsule based endoscopy has been conducted using modalities such as OCT [220][221][222] , autofluorescence 223 capsule-like device to identify Barrett oesophagus on human volunteers. Results showed sensitivity, specificity and 10 accuracy of 94%, 93% and 94% respectively.…”

mentioning

confidence: 99%