Optical coherence tomography in pediatric patients: A feasible technique for diagnosing celiac disease in children with villous atrophy

Masci, E.; Mangiavillano, Benedetto; Barera, Graziano; Parma, Barbara; Albarello, Luca; Mariani, Alberto; Doglioni, Claudio; Testoni, P.A.

doi:10.1016/j.dld.2009.02.002

Cited by 23 publications

(12 citation statements)

References 20 publications

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“…OCT, with its capability to image entire luminal organs, can change this equation by comprehensively imaging large regions of the duodenum to assess villous blunting without the sampling error that is inherent in endoscopic biopsy [146]. Indeed, a recent study showed that OCT has a sensitivity and specificity of 82% and 100% [147], respectively, compared to histology, adding further evidence for its potential to improve our capacity to obtain a tissue diagnosis of celiac disease.…”

Section: Gastrointestinal Tractmentioning

confidence: 99%

Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

Gora¹,

Suter²,

Tearney³

et al. 2017

Biomed. Opt. Express

262

203

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Abstract:In this paper, we review the current state of technology development and clinical applications of endoscopic optical coherence tomography (OCT). Key design and engineering considerations are discussed for most OCT endoscopes, including side-viewing and forwardviewing probes, along with different scanning mechanisms (proximal-scanning versus distalscanning). Multi-modal endoscopes that integrate OCT with other imaging modalities are also discussed. The review of clinical applications of endoscopic OCT focuses heavily on diagnosis of diseases and guidance of interventions. Representative applications in several organ systems are presented, such as in the cardiovascular, digestive, respiratory, and reproductive systems. A brief outlook of the field of endoscopic OCT is also discussed. References and links 1. T. Cao and H. L. Tey, "High-definition optical coherence tomography -an aid to clinical practice and research in dermatology," J. Dtsch. Dermatol. Ges. 13(9), 886-890 (2015). 2. J. Olsen, L. Themstrup, and G. B. Jemec, "Optical coherence tomography in dermatology," G. Ital. Dermatol.Venereol. 150(5), 603-615 (2015). 3. M. Ulrich, L. Themstrup, N. de Carvalho, M. Manfredi, C. Grana, S. Ciardo, R. Kästle, J. Holmes, R.Whitehead, G. B. Jemec, G. Pellacani, and J. Welzel, "Dynamic Optical Coherence Tomography in Dermatology," Dermatology (Basel) 232(3), 298-311 (2016). 4. G. J. Tearney, S. A. Boppart, B. E. Bouma, M. E. Brezinski, N. J. Weissman, J. F. Southern, and J. G. Fujimoto, "Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography," Opt. Lett. 21(7), 543-545 (1996). 5. A. M. Rollins, R. Ung-Arunyawee, A. Chak, R. C. K. Wong, K. Kobayashi, M. V. Sivak, Jr., and J. A. Izatt, "Real-time in vivo imaging of human gastrointestinal ultrastructure by use of endoscopic optical coherence tomography with a novel efficient interferometer design," Opt. Lett. 24(19), 1358-1360 (1999). 6. M. V. Sivak, Jr., K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A.Isenberg, and J. Willis, "High-resolution endoscopic imaging of the GI tract using optical coherence tomography," Gastrointest. Endosc. 51(4), 474-479 (2000). 7. J. Xi, A. Zhang, Z. Liu, W. Liang, L. Y. Lin, S. Yu, and X. Li, "Diffractive catheter for ultrahigh-resolution spectral-domain volumetric OCT imaging," Opt. Lett. 39(7), 2016-2019 (2014). 8. P. H. Tran, D. S. Mukai, M. Brenner, and Z. Chen, "In vivo endoscopic optical coherence tomography by use of a rotational microelectromechanical system probe," Opt. Lett. 29(11), 1236-1238 (2004). Goodnow, and C. Petersen, "Micromotor endoscope catheter for in vivo, ultrahigh-resolution optical coherence tomography," Opt. Lett. 29(19), 2261-2263 (2004). 10. T.-H. Tsai, B. Potsaid, Y. K. Tao, V. Jayaraman, J. Jiang, P. J. S. Heim, M. F. Kraus, C. Zhou, J. Hornegger, H.Mashimo, A. E. Cable, and J. G. Fujimoto, "Ultrahigh speed endoscopic optical coherence tomography using micromotor imaging catheter and VCSEL technology," Biomed. Opt. Express 4(7), 1119-11...

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Section: Gastrointestinal Tractmentioning

confidence: 99%

Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

Gora¹,

Suter²,

Tearney³

et al. 2017

Biomed. Opt. Express

262

203

View full text Add to dashboard Cite

show abstract

“…Sensitivity and specificity were 82% and 100%, respectively. The overall concordance between optical coherence tomography and histology in determining patchy lesions was 75% [66].…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

Current technologies for the endoscopic assessment of duodenal villous pattern in celiac disease

Ianiro

Bibbò

Pecere

et al. 2015

Computers in Biology and Medicine

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“…These features are neither sensitive nor specific enough to be used as screening tools during endoscopy 40,42,45,46. Endoscopic clues to villous atrophy may also indicate the need for biopsies or also provide direction for targeted biopsies 41…”

Section: Diagnosismentioning

confidence: 99%

“…Optical coherence tomography combines ultrasound and infrared back-scattering light to visualize the mucosa and submucosa with a sensitivity and specificity of 82% and 100%, respectively 46. Like endocytoscopy, optical coherence tomography is limited in its inability to assess hypertrophic crypts and intraepithelial lymphocyte count 46…”

Section: Diagnosismentioning

confidence: 99%

Update on celiac disease – etiology, differential diagnosis, drug targets, and management advances

Scanlon¹,

Murray²

2011

CEG

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Celiac disease (CD) is an immune-mediated enteropathy triggered by exposure to wheat gluten and similar proteins found in rye and barley that affects genetically susceptible persons. This immune-mediated enteropathy is characterized by villous atrophy, intraepithelial lymphocytosis, and crypt hyperplasia. Once thought a disease that largely presented with malnourished children, the wide spectrum of disease activity is now better recognized and this has resulted in a shift in the presenting symptoms of most patients with CD. New advances in testing, both serologic and endoscopic, have dramatically increased the detection and diagnosis of CD. While the gluten-free diet is still the only treatment for CD, recent investigations have explored alternative approaches, including the use of altered nonimmunogenic wheat variants, enzymatic degradation of gluten, tissue transglutaminase inhibitors, induction of tolerance, and peptides to restore integrity to intestinal tight junctions.

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Optical coherence tomography in pediatric patients: A feasible technique for diagnosing celiac disease in children with villous atrophy

Cited by 23 publications

References 20 publications

Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

Current technologies for the endoscopic assessment of duodenal villous pattern in celiac disease

Update on celiac disease – etiology, differential diagnosis, drug targets, and management advances

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Optical coherence tomography in pediatric patients: A feasible technique for diagnosing celiac disease in children with villous atrophy

Cited by 23 publications

References 20 publications

Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

Current technologies for the endoscopic assessment of duodenal villous pattern in celiac disease

Update on celiac disease &ndash; etiology, differential diagnosis, drug targets, and management advances

Contact Info

Product

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Update on celiac disease – etiology, differential diagnosis, drug targets, and management advances