Optical coherence tomography is a valuable tool in the study of the effects of microneedle geometry on skin penetration characteristics and in-skin dissolution

Donnelly, Ryan F.; Garland, Martin J.; Morrow, Desmond I. J.; Migalska, Katarzyna; Singh, Thakur Raghu Raj; Majithiya, Rita; Woolfson, A. David

doi:10.1016/j.jconrel.2010.08.008

Cited by 246 publications

(190 citation statements)

References 37 publications

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“…These results are in agreement with similar studies (Donnelly et al, 2010), which showed different permeation profiles for theophylline loaded polymeric MNs of different heights (350m and 900m) by piercing neonatal porcine skin or with silicon MNs with different needle lengths (ranging from 100 to 1100m) (Yan et al, 2010). Depending on the skin thickness the drug has to diffuse different distances before finally reaching the acceptor compartment.…”

Section: Resultssupporting

confidence: 92%

Inkjet printing of transdermal microneedles for the delivery of anticancer agents

Uddin

Scoutaris

Klepetsanis

et al. 2015

International Journal of Pharmaceutics

160

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A novel inkjet printing technology is introduced as a process to coat metal microneedle arrays with three anticancer agents 5-fluororacil, curcumin and cisplatin for transdermal delivery. The hydrophilic graft copolymer Soluplus® was used as a drug carrier and the coating formulations consisted of drug -polymer solutions at various ratios. A piezoelectric dispenser jetted microdroplets on the microneedle surface to develop uniform, accurate and reproducible coating layers without any material losses. Inkjet printing was found to depend on the nozzle size, the applied voltage (mV) and the duration of the pulse (s). The drug release rates were determined in vitro using Franz type diffusion cells with dermatomed porcine skin. The drug release rates depended on the drug-polymer ratio, the drug lipophilicity and the skin thickness. All drugs presented increased release profiles (750 m skin thickness), which were retarded for 900 m skin thickness. Soluplus assisted the drug release especially for the water insoluble curcumin and cisplatin due to its solubilizing capacity. Inkjet printing was proved an effective technology for coating of metal microneedles which can then be used for further transdermal drug delivery applications.

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Section: Resultssupporting

confidence: 92%

Inkjet printing of transdermal microneedles for the delivery of anticancer agents

Uddin

Scoutaris

Klepetsanis

et al. 2015

International Journal of Pharmaceutics

160

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“…shown that the depth of MN penetration into the skin is critically dependent upon the force used for MN application (Donnelly et al, 2010). This finding suggests that to ensure consistent MN penetration on a patient -to -patient basis, it may be necessary to develop a suitable application method and device, rather than relying on manual insertion of MNs.…”

Section: Introductionmentioning

confidence: 99%

Influence of Array Interspacing on the Force Required for Successful Microneedle Skin Penetration: Theoretical and Practical Approaches

Olatunji

Das

Garland

et al. 2013

Journal of Pharmaceutical Sciences

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201

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“…At an application force of 11.0 N/array, it was found that, in each case, increasing microneedle height from 350 to 600 µm to 900 µm led to a significant increase in the depth of microneedle penetration achieved. [29] TCP Transl Clin Pharmacol Skin permeation of vitamin C When five different application times were applied, the highest permeability of 2051.39 µg/cm 2 was shown in application time of 5 min with a fixed level 2 of vibration intensity and 700 g of application power (Table 3). Therefore, the optimal application conditions for the vibrating microneedles on permeability by vitamin C were vibration intensity of level 3, application power of 1,000 g, and application time of 5 min.…”

Section: Effects Of Application Conditions Of Vibrating Microneedles mentioning

confidence: 99%

Enhancement of skin permeation of vitamin C using vibrating microneedles

Lee

Baek

Kwag

et al. 2017

Transl Clin Pharmacol

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This study was performed to evaluate the use of vibrating microneedles for the transdermal delivery of vitamin C. The microneedles were designed to vibrate at three levels of intensity. In vitro permeation by vitamin C was evaluated according to the specific conditions such as vibration intensity (levels 1, 2 and 3), application time (1, 3, 5, 7 and 10 min), and application power (500, 700 and 1,000 g). The highest permeation of vitamin C was observed at level 3 of vibration intensity, 5 min of application, and 1,000 g of application power. Vitamin C gel showed no cytotoxic effect against Pam212 cells or skin irritation effects. A pharmacokinetic study of the gel in rats was conducted under optimized conditions. The AUC 0 -∞ and C max increased 1.35-fold and 1.44-fold, respectively, compared with those after vitamin C gel without application with vibrating microneedles. The present study suggests that vibrating microneedles can be used to facilitate the skin permeability of vitamin C under optimal conditions.

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Optical coherence tomography is a valuable tool in the study of the effects of microneedle geometry on skin penetration characteristics and in-skin dissolution

Cited by 246 publications

References 37 publications

Inkjet printing of transdermal microneedles for the delivery of anticancer agents

Inkjet printing of transdermal microneedles for the delivery of anticancer agents

Influence of Array Interspacing on the Force Required for Successful Microneedle Skin Penetration: Theoretical and Practical Approaches

Enhancement of skin permeation of vitamin C using vibrating microneedles

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