Optical Coherence Tomography-Raster Scanning and Manual Segmentation in Determining Drusen Volume in Age-Related Macular Degeneration

Freeman, Samuel; Kozák, Igor; Cheng, Lingyun; Bartsch, Dirk-Uwe; Mojana, Francesca; Nigam, Nitin; Brar, Manpreet; Yuson, R. M. S.; Freeman, William R.

doi:10.1097/iae.0b013e3181bd2f94

Cited by 69 publications

(66 citation statements)

References 21 publications

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“…133 Using higher-quality images compared with the original Rodenstock SLO, the investigation of retinal sensitivity in the junctional zone of patients with atrophic AMD using OCT/SLO MP was repeated. 96 Similar to the original report, findings of variable but definite reduction in retinal sensitivity was noted in patients with increased FAF intensity in the junctional zone. RPE cell damage in the regions characterized by increased FAF was also confirmed by SD-OCT imaging.…”

supporting

confidence: 74%

“…96,102,125 Prior to this, MP layer. 127 The relationship between the IS-OS layer and retinal sensitivity has been reported in a variety of diseases.…”

Section: Microperimetrymentioning

confidence: 99%

“…96 In addition to monitoring drusen load to predict disease progression, several studies have attempted drusen reduction as a means of preventing vision loss. [97][98][99] However, before accurate correlations can be made between changes in drusen load and disease state, a reliable mechanism for quantifying drusen must be established.…”

Section: 82mentioning

confidence: 99%

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Scanning Laser Ophthalmoscope in the Management of Age-related Macular Degeneration

Scripsema¹,

Rosen²

2012

US Ophthalmic Review

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Recent advances in retinal imaging have improved the evaluation and prognostication of age-related macular degeneration. The development and modification of the scanning laser ophthalmoscope (SLO) has played a pivotal role in our understanding of the disease. SLO has led to improved methods of visualizing characteristics of the disease, such as drusen and alterations in autofluorescence, and also provided a platform for the quantification of structural and functional changes occurring as a result of the disease process. This article provides a review of the current literature on the impact and clinical utility of SLO devices for infrared viewing, fundus autofluorescence, microperimetry, and as integraded multimodal imaging systems such as optical coherence tomography and SLO.

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supporting

confidence: 74%

“…96,102,125 Prior to this, MP layer. 127 The relationship between the IS-OS layer and retinal sensitivity has been reported in a variety of diseases.…”

Section: Microperimetrymentioning

confidence: 99%

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Scanning Laser Ophthalmoscope in the Management of Age-related Macular Degeneration

Scripsema¹,

Rosen²

2012

US Ophthalmic Review

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“…13 Spectral-domain OCT (SD-OCT) has been demonstrated as a useful technique in the characterization of AMD. [14][15][16] Previous investigations of the relationship between these structural and functional measures in patients with early and late AMD, using SLO microperimetry combined with SD-OCT, have shown significant correlations between retinal sensitivity and drusen volume 11 and between sensitivity and integrity of the inner segment/outer segment junction 11,17 (herein called the inner segment ellipsoid [ISe] band 18 ). Another study described an association between retinal thinning and rod-mediated light sensitivity in nonexudative AMD.…”

Section: Resultsmentioning

confidence: 99%

Relationship between Retinal Layer Thickness and the Visual Field in Early Age-Related Macular Degeneration

Acton

Rjh

Hood

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To quantify and compare the structural and functional changes in subjects with early age-related macular degeneration (AMD), using spectral-domain optical coherence tomography (SD-OCT) and microperimetry.METHODS. Twenty-one eyes of 21 subjects with early AMD were examined. MP-1 10-2 visual fields (VFs) and SD-OCT line and detail volume scans were acquired. The thicknesses of the outer segment (OS; distance between inner segment ellipsoid band and upper retinal pigment epithelium [RPE] border) and RPE layers and elevation of the RPE from Bruch's membrane were measured using a computer-aided manual segmentation technique. Thickness values were compared with those for 15 controls, and values at locations with VF total deviation defects were compared with values at nondefect locations at equivalent eccentricities. RESULTS.Sixteen of 21 eyes with AMD had VF defects. Compared with controls, line scans showed significant thinning of the OS layer (P ¼ 0.006) and thickening and elevation of the RPE (P ¼ 0.037, P ¼ 0.002). The OS layer was significantly thinner in locations with VF defects compared with locations without defects (P ¼ 0.003). There was a negligible difference between the retinal layer thickness values of the 5 eyes without VF defects and the values of normal controls.CONCLUSIONS. In early AMD, when VF defects were present, there was significant thinning of the OS layer and thickening and elevation of the RPE. OS layer thinning was significantly associated with decreased visual sensitivity, consistent with known photoreceptor loss in early AMD. For AMD subjects without VF defects, thickness values were normal. The results highlight the clinical utility of both SD-OCT retinal layer quantification and VF testing in early AMD. (Invest Ophthalmol Vis Sci. 2012;53:7618-7624) DOI:10.1167/iovs.12-10361 A ge-related macular degeneration (AMD) is the third leading cause of blindness worldwide, accounting for 8.7% of blindness in the global population.1 Due to the increase in the average lifespan of the elderly population, it is expected that 17.8 million individuals in the United States will be affected by 2050.2 In view of the relevance of AMD as a public health issue, it is important to understand the changes that occur in the early stages of disease, which may lead to improved future intervention strategies.There has been recent interest in the use of fundus perimetry, also known as microperimetry, as an outcome measure in clinical trials of macular disease.3-7 Functional loss due to AMD was previously demonstrated by findings of reduced visual field sensitivity in retinal locations with drusen compared with nondrusen locations, using scanning laser ophthalmoscope (SLO) perimetry and microperimetry. [8][9][10][11] In contrast, other studies reported no difference in sensitivity between drusen and nondrusen areas. 12Optical coherence tomography (OCT) is a noninvasive imaging technique that provides cross-sectional images of retinal layer structure, useful for visualization of pathology. Spectral-domain O...

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“…High-quality individual B-scans are able to show fine details of drusen structure and morphology 18 and estimate damage to the photoreceptor layer over the drusen. 19 Furthermore, recent studies have shown the potential of SD-OCT to quantify geometrical parameters of the RPE deformations typically associated with drusen, using manual measurement of drusen volume, 20 semiautomatic measurement of drusen area and drusen size, 21,22 and automatic detection and measurement of drusen area, height, and volume. [23][24][25][26][27] To better understand the relationship between drusen defined as pigmentary changes on fundus photography and drusen defined in terms of RPE geometry, we compared the area measurements obtained using both imaging modalities.…”

mentioning

confidence: 99%

Comparison of Drusen Area Detected by Spectral Domain Optical Coherence Tomography and Color Fundus Imaging

Yehoshua

Gregori

Sadda

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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Citation: Yehoshua Z, Gregori G, Sadda SR, et al. Comparison of drusen area detected by spectral domain optical coherence tomography and color fundus imaging. Invest Ophthalmol Vis Sci. 2013;54;4:24294: -24344: . DOI:10.1167 PURPOSE. To compare the measurements of drusen area from manual segmentation of color fundus photographs with those generated by an automated algorithm designed to detect elevations of the retinal pigment epithelium (RPE) on spectral domain optical coherence tomography (SD-OCT) images. METHODS.Fifty eyes with drusen secondary to nonexudative age-related macular degeneration were enrolled. All eyes were imaged with a high-definition OCT instrument using a 200 3 200 A-scan raster pattern covering a 6 mm 3 6 mm area centered on the fovea. Digital color fundus images were taken on the same day. Drusen were traced manually on the fundus photos by graders at the Doheny Image Reading Center, whereas quantitative OCT measurements of drusen were obtained by using a fully automated algorithm. The color fundus images were registered to the OCT data set and measurements within corresponding 3-and 5-mm circles centered at the fovea were compared. . The mean differences between color images and the SD-OCT (color À SD-OCT) were 0.36 (60.93) (P ¼ 0.008) for the 3-mm circle and 1.26 (61.38) (P < 0.001) for the 5-mm circle measurements. Intraclass correlation coefficients of agreements for 3-and 5-mm measurements were 0.599 and 0.540, respectively. RESULTS. The mean areas (6SD [rangeCONCLUSIONS. There was only fair agreement between drusen area measurements obtained from SD-OCT images and color fundus photos. Drusen area measurements on color fundus images were larger than those with SD-OCT scans. This difference can be attributed to the fact that the OCT algorithm defines drusen in terms of RPE deformations above a certain threshold, and will not include small, flat drusen and subretinal drusenoid deposits. The two approaches provide complementary information about drusen.

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Optical Coherence Tomography-Raster Scanning and Manual Segmentation in Determining Drusen Volume in Age-Related Macular Degeneration

Cited by 69 publications

References 21 publications

Scanning Laser Ophthalmoscope in the Management of Age-related Macular Degeneration

Scanning Laser Ophthalmoscope in the Management of Age-related Macular Degeneration

Relationship between Retinal Layer Thickness and the Visual Field in Early Age-Related Macular Degeneration

Comparison of Drusen Area Detected by Spectral Domain Optical Coherence Tomography and Color Fundus Imaging

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