Optical Coherence Tomography Reveals New Insights into the Accommodation Mechanism

Farouk, Mahmoud; Naito, Toshio; Shinomiya, Kayo; Eguchi, Hiroshi; Sayed, Khulood Mohammed; Nagasawa, Toshihiko; Katome, Takashi; Mitamura, Yoshinori

doi:10.1155/2015/510459

Cited by 11 publications

(5 citation statements)

References 15 publications

(26 reference statements)

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“…The ACD and anterior chamber width (ACW) were measured using the horizontal (0°–180°) and vertical (90°–270°) slices. After manually locating the angle recesses, the ACD were automatically calculated by the system [13]. The ACW and lens vault (LV) were measured manually, ACW was the distance between the two scleral spurs, and LV was defined as the distance between the anterior surface of the crystalline lens and the spur-to-spur line (Figure S1, in Supplementary Material available online at https://doi.org/10.1155/2017/6762047).…”

Section: Methodsmentioning

confidence: 99%

Measurement of and Factors Associated with the Anterior Chamber Volume in Healthy Chinese Adults

Zong

Jiang

et al. 2017

Journal of Ophthalmology

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Purpose. To measure the anterior chamber volume (ACV) and determine factors associated with the ACV in healthy Chinese adults. Methods. In this cross-sectional study, we used swept-source optical coherence tomography (SS-OCT) to measure ACV and other anterior segment parameters. Factors associated with ACV were also determined. Results. A total of 313 healthy Chinese adults were enrolled. The anterior segment parameters, including ACV, could be measured by SS-OCT with excellent repeatability and reproducibility. There was a significant difference between the horizontal and vertical anterior chamber widths (ACW) (P < 0.05), with a mean difference of 390 μm. The ACV (mean 153.83 ± 32.42 mm3) was correlated with most of the anterior segment parameters, especially anterior chamber depth (ACD), which accounted for about 85% of the variation of ACV. Most of the anterior segment parameters were significantly correlated with age, and the relative changes in ACV and ACD were greatest in subjects aged 41–50 years. Conclusion. ACV was correlated with most of the anterior segment parameters measured in this study, particularly ACD. The relatively large difference between horizontal and vertical ACW suggests that the ACV could and should be measured using multiple OCT scans.

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Section: Methodsmentioning

confidence: 99%

Measurement of and Factors Associated with the Anterior Chamber Volume in Healthy Chinese Adults

Zong

Jiang

et al. 2017

Journal of Ophthalmology

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“…On the other hand, the ACD and PD decreased after -6D accommodation stimulation whereas it increased after cycloplegia with tropicamide. Thus two typical artificial accommodation states were established in myopia children as previously reported 12,15,16 .…”

Section: Schlemm's Canal Changed In Different Accommodation States Ofmentioning

confidence: 55%

Measuring changes in Schlemm’s canal and trabecular meshwork in different accommodation states in myopia children: an observational study

Xiang

Chen

Zhao

et al. 2019

Eye

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Purpose: Studies were designed to evaluate changes in the size of the Schlemm's Canal (SC) and trabecular meshwork(TM) during accommodation stimuli and cycloplegia states in myopic children. Methods: 34 children were enrolled. A-6D accommodation stimulus was achieved by looking at an optotype through a mirror. Cycloplegia state was induced with 1% tropicamide. Two states were confirmed by measuring the central lens thickness (CLT) , the anterior chamber depth and the pupil diameter. The size of the Schlemm's Canal (SC) and Trabecular Meshwork(TM) was measured using swept-source optical coherence tomography. And the associations between the change of the SC and the CLT were analyzed. Results: When compared with the relaxation state, under-6D accommodation stimuli, the size of SC increased significantly: the SC area (SCA) amplified from 6371±2517μm 2 to 7824±2727 μm 2 ; the SC length (SCL) from 249±10 μm to 295±12 μm, and SC width (SCW) from 27±9 μm to 31±8 μm. Under cycloplegia state, the SCA reduced to 5009±2028 μm 2 ; the SCL to 212±μm and the SCW to 22±5 μm. In addition, the changed areas of SCA (r=0. 35; P=0.0007), SCL (r=0. 251; P=0.0172), and SCW (r=0. 253; P=0.016) were significantly correlated with the change in CLT. However, the size of TM did not change substantially when compared with the relaxation state. Only the TM length (TML) increased from 562±45μm to 587±47μm after-6D accommodation stimulus. Conclusion: SC size enlarges after-6D accommodation stimuli and shrinks under cycloplegia. However, for TM, only the TM length increase under accommodation stimulus state.

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“…Accommodation in children was studied also by OCT, demonstrating similar results as in adults and proved to be suitable for ciliary muscle as well as to evaluate the changes in the anterior chamber depth and lens thickness during accommodation (7,8).…”

Section: Introductionmentioning

confidence: 79%

Observation of Ciliary Body Changes during Accommodation Using Anterior OCT

et al. 2018

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: Aim : To evaluate the anatomical changes in the ciliary body (CB) during naturally stimulated accommodation in children using anterior segment optical coherence tomography (OCT). Methods : This study was a prospective, observational, noncomparative case series included 18 eyes of 9 children (8 males and 1female) aged from 4 to 10 years. Ciliary body thickness (CBT) was measured temporally by Anterior OCT at 1, 2 and 3 mm posterior to the scleral spur. Measurements were performed in the accommodated state and the unaccommodated state (with cycloplegia). Results : The mean CBT significantly increased by accommodation at 1 mm posterior to the scleral spur from 751 42 to 818 40 μm (P 0.001) and significantly decreased at 2 and 3 mm from 506 66 to 445 59 μm and from 290 54 to 240 50 μm respectively (P 0.001). Conclusion : During accommodation, the anterior portion of the ciliary body thickens, while the posterior portion decreases in thickness. These findings imply that the circular ciliary muscles are mainly involved in accommodation and not the longitudinal muscles.

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Optical Coherence Tomography Reveals New Insights into the Accommodation Mechanism

Cited by 11 publications

References 15 publications

Measurement of and Factors Associated with the Anterior Chamber Volume in Healthy Chinese Adults

Measurement of and Factors Associated with the Anterior Chamber Volume in Healthy Chinese Adults

Measuring changes in Schlemm’s canal and trabecular meshwork in different accommodation states in myopia children: an observational study

Observation of Ciliary Body Changes during Accommodation Using Anterior OCT

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