Optical Coherence Tomography Study of Retinal and Choroidal Changes in Patients with Chronic Obstructive Pulmonary Disease

El-Naser, Mai G. Abd; El-Rahman, Heba M. Abd; Adawy, Zeinab; Aly, Mona M

doi:10.21608/ejhm.2019.30967

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…Corroboratory genetic evidence for this was also observed, with genetic predisposition to lower FEV1 and FVC being associated with thinner RNFL and PS layers. Thinning of the RNFL and choroid have been associated with COPD in a number of cross-sectional studies ( 53 – 55 ). OCT studies in the context of infectious pneumonia are few in number and mostly relate to SARS-CoV-2 (COVID-19), which is variably reported to be associated with reduced macular thickness and RNFL thinning ( 56 ), as well as increased RNFL and GCC thickness compared with controls.…”

Section: Discussionmentioning

confidence: 99%

Phenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic health

Zekavat,

Jorshery,

Rauscher

et al. 2024

Sci. Transl. Med.

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The human retina is a multilayered tissue that offers a unique window into systemic health. Optical coherence tomography (OCT) is widely used in eye care and allows the noninvasive, rapid capture of retinal anatomy in exquisite detail. We conducted genotypic and phenotypic analyses of retinal layer thicknesses using macular OCT images from 44,823 UK Biobank participants. We performed OCT layer cross-phenotype association analyses (OCT-XWAS), associating retinal thicknesses with 1866 incident conditions (median 10-year follow-up) and 88 quantitative traits and blood biomarkers. We performed genome-wide association studies (GWASs), identifying inherited genetic markers that influence retinal layer thicknesses and replicated our associations among the LIFE-Adult Study ( N = 6313). Last, we performed a comparative analysis of phenome- and genome-wide associations to identify putative causal links between retinal layer thicknesses and both ocular and systemic conditions. Independent associations with incident mortality were detected for thinner photoreceptor segments (PSs) and, separately, ganglion cell complex layers. Phenotypic associations were detected between thinner retinal layers and ocular, neuropsychiatric, cardiometabolic, and pulmonary conditions. A GWAS of retinal layer thicknesses yielded 259 unique loci. Consistency between epidemiologic and genetic associations suggested links between a thinner retinal nerve fiber layer with glaucoma, thinner PS with age-related macular degeneration, and poor cardiometabolic and pulmonary function with a thinner PS. In conclusion, we identified multiple inherited genetic loci and acquired systemic cardio-metabolic-pulmonary conditions associated with thinner retinal layers and identify retinal layers wherein thinning is predictive of future ocular and systemic conditions.

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Section: Discussionmentioning

confidence: 99%

Phenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic health

Zekavat,

Jorshery,

Rauscher

et al. 2024

Sci. Transl. Med.

View full text Add to dashboard Cite

show abstract

“…Corroboratory genetic evidence for this was also observed, with genetic predisposition to lower FEV1 and FVC being associated with thinner RNFL and PS layers. Thinning of the RNFL and choroid have been associated with COPD in a number of cross-sectional studies (81)(82)(83)(84)(85). OCT studies in the context of infectious pneumonia are few in number and mostly relate to SARS-CoV-2 (COVID-19), which is variably reported to be associated with reduced macular thickness and RNFL thinning (86), as well as increased RNFL and GCC thickness compared to controls (87).…”

Section: Discussionmentioning

confidence: 99%

Insights into human health from phenome- and genome-wide analyses of UK Biobank retinal optical coherence tomography phenotypes

Zekavat,

Jorshery,

Shweikh

et al. 2023

Preprint

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The human retina is a complex multi-layered tissue which offers a unique window into systemic health and disease. Optical coherence tomography (OCT) is widely used in eye care and allows the non-invasive, rapid capture of retinal measurements in exquisite detail. We conducted genome- and phenome-wide analyses of retinal layer thicknesses using macular OCT images from 44,823 UK Biobank participants. We performed phenome-wide association analyses, associating retinal thicknesses with 1,866 incident ICD-based conditions (median 10-year follow-up) and 88 quantitative traits and blood biomarkers. We performed genome-wide association analyses, identifying inherited genetic markers which influence the retina, and replicated our associations among 6,313 individuals from the LIFE-Adult Study. And lastly, we performed comparative association of phenome- and genome- wide associations to identify putative causal links between systemic conditions, retinal layer thicknesses, and ocular disease. Independent associations with incident mortality were detected for photoreceptor thinning and ganglion cell complex thinning. Significant phenotypic associations were detected between retinal layer thinning and ocular, neuropsychiatric, cardiometabolic and pulmonary conditions. Genome-wide association of retinal layer thicknesses yielded 259 loci. Consistency between epidemiologic and genetic associations suggested putative causal links between thinning of the retinal nerve fiber layer with glaucoma, photoreceptor segment with AMD, as well as poor cardiometabolic and pulmonary function with PS thinning, among other findings. In conclusion, retinal layer thinning predicts risk of future ocular and systemic disease. Furthermore, systemic cardio-metabolic-pulmonary conditions promote retinal thinning. Retinal imaging biomarkers, integrated into electronic health records, may inform risk prediction and potential therapeutic strategies.

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Evaluation of the impact of COPD severity grading and oxygen saturation on the retinal nerve fiber layer thickness and subfoveal choroidal thickness in COPD patients

2021

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Background Retinal and choroidal blood vessels are involved in many systemic diseases because they are complex vascular systems. Chronic obstructive pulmonary disease is considered as an inflammatory disease that affects many systems and coexists with several co-morbidities. Systemic inflammation and hypoxia affect the macula, choroid, retinal nerve fiber layer (RNFL), and blood vessels. Ocular co-morbidities have been detected in COPD patients. These can be quantitatively and qualitatively evaluated by Spectral Domain Optical Coherence Tomography (SD-OCT). Enhanced depth imaging OCT (EDI-OCT) is a quite new technique that utilizes light with an extended wavelength. An apparent relation has been found between chronic pulmonary disease and low corneal endothelial cell density preoperatively. So this work aimed to assess the impact of COPD severity grading and oxygen saturation on retinal nerve fiber layer thickness and subfoveal choroidal thickness. Results This was a case-control study, recruited 50 COPD patients and another 50 healthy volunteers as a control group. Measuring the thickness of the RNFL (superior, inferior, nasal, and temporal) in the four quadrants as well as the subfoveal choroidal thickness was done to both groups. The RNFL thickness in all quadrants and the SFCT in the COPD group were statistically significantly thinner in comparison to the control group. The RNFL thickness (mean) was 79.16 ± 10.49 μm compared to 96.30 ± 4.66 μm in the control group (p value 0.001). The SFCT (mean) was 213.12 ± 25.61 μm compared to 354.62 ± 53.82 μm in the control group (p value 0.001). The degree of thinning of the RNFL (superior, inferior, and temporal) and the SCFT was related to COPD (GOLD) stages severity (p value 0.001). Nasal RNFL was thinned out in all stages of COPD (GOLD) but with no statistical significance (p value 0.264). Conclusion The choroid and retina seem to be of the affected tissues during the progressive inflammatory course of COPD. Ocular pathologies should be evaluated in patients with systemic hypoxia. The eye examination for COPD patients can be carried out via a non-invasive procedure such as the OCT and the changes in the RNFL and SFCT thickness could be used as indicators for the severity of COPD.

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Optical Coherence Tomography Study of Retinal and Choroidal Changes in Patients with Chronic Obstructive Pulmonary Disease

Cited by 4 publications

References 21 publications

Phenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic health

Phenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic health

Insights into human health from phenome- and genome-wide analyses of UK Biobank retinal optical coherence tomography phenotypes

Evaluation of the impact of COPD severity grading and oxygen saturation on the retinal nerve fiber layer thickness and subfoveal choroidal thickness in COPD patients

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