Optical fiber amplifier and thermometer assisted point-of-care biosensor for detection of cancerous exosomes

Zou, Liyuan; Liu, Xiaofeng; Zhou, Yuan; Mei, Wenjing; Wang, Qing; Yang, Xiaohai

doi:10.1016/j.snb.2021.130893

Cited by 15 publications

(8 citation statements)

References 30 publications

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“…The challenge of sensor technology in cancer research is the development of simple, reliable, and sensitive point-of-care testing biosensors for cancerous exosome detection to early cancer diagnosis and prognosis. The biosensor is a main technology for cancer research that could also avoid the influence of the external environment, including surrounding light and temperature [55].…”

Section: Discussionmentioning

confidence: 99%

Sensor Technology for Opening New Pathways in Diagnosis and Therapeutics of Breast, Lung, Colorectal and Prostate Cancer

Roshani

Coccia

Mosleh

2022

HighTech. Innov. J.

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This study analyzes the interaction between sensor research and technology and different types of cancer (breast, lung, colorectal, and prostate) with the goal of detecting new directions for improving diagnosis and therapeutics in medicine. This study develops an approach to computational scientometrics based on data from the Web of Science from the 1991 to 2021 period. The results of this analysis show the vital role of biosensors and electrochemical biosensors applied in breast cancer, lung cancer, and prostate cancer research. Instead, scientific research of optical sensors is developing main technological trajectories in breast, prostate, and colorectal cancer for improving diagnostics. Finally, oxygen sensor research has a main technological development in breast and lung cancer for new applications in breath analysis directed to treatment processes. Preliminary results presented here clearly illustrate the evolutionary paths of sensor research and technologies that have great potential for developing incremental and radical innovations in cancer diagnosis and therapies. These conclusions are, of course, tentative. There is a need for much more detailed research based on other aspects and factors for detecting stable technological trajectories that can foster the technology transfer of new sensor in cancer research for improving diagnosis and therapeutics, reducing, whenever possible, world-wide mortality of cancer in society.JEL Classification: I10, O30, O31, O32; O33. Doi: 10.28991/HIJ-2022-03-03-010 Full Text: PDF

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Section: Discussionmentioning

confidence: 99%

Sensor Technology for Opening New Pathways in Diagnosis and Therapeutics of Breast, Lung, Colorectal and Prostate Cancer

Roshani

Coccia

Mosleh

2022

HighTech. Innov. J.

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“…The challenge of sensor technology in cancer research is the developing of simple, reliable and sensitive point-of-care testing biosensor for cancerous exosomes detection to early cancer diagnosis and prognosis. The biosensor could also avoid the influence of the external environment, including surrounding light and temperature ( Zou et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Sensor Technology for Opening New Pathways in Diagnosis and Therapeutics of Breast, Lung, Colorectal and Prostate Cancer

Roshani

Coccia

Mosleh

2022

Preprint

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This study analyzes the interaction between sensor research and technology and different types of cancer (breast, lung, colorectal and prostate) that generates a high mortality in society with the goals of detecting new directions for improving diagnosis and therapeutics. This study develops an approach of computational scientometrics based on data of the Web of Science from 1991 to 2021 period. The results of this analysis show the vital role of biosensor and electrochemical biosensor applied in breast cancer, lung cancer, and prostate cancer research, except colorectal cancer for latter one. Instead, research of optical sensors is developing mainly in the directions of breast, prostate, and colorectal cancer for improving diagnostics. Finally, oxygen sensor research is developing for breast and lung cancer for applications in breath analysis in new treatment processes. Preliminary results presented here clearly illustrate the evolutionary paths of main sensor technologies that have a great potential in future diagnosis of cancer, but we also need additional examinations of other aspects and factors for supporting appropriate strategies of management of technology to foster the technology transfer of sensor technologies in cancer research for improving diagnosis and, whenever possible, reduce world-wide mortality of cancer ins society.

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“…Exosomes are captured using a particular antibody, tagged with a fluorescent dye and measured by a plate reader in microfluidic-dependent Fluorescence Correlation Microscopy (FCM). A microfluidic chip used for immunocapture and quantitative exosome analysis can be developed using FCM [ 107 ].…”

Section: Characterization Of Exosomesmentioning

confidence: 99%

Exosomes as New Generation Vehicles for Drug Delivery: Biomedical Applications and Future Perspectives

Rajput

Varshney²,

Bajaj³

et al. 2022

Molecules

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Currently, particular interest among the scientific community is focused on exploring the use of exosomes for several pharmaceutical and biomedical applications. This is due to the identification of the role of exosomes as an excellent intercellular communicator by delivering the requisite cargo comprising of functional proteins, metabolites and nucleic acids. Exosomes are the smallest extracellular vesicles (EV) with sizes ranging from 30–100 nm and are derived from endosomes. Exosomes have similar surface morphology to cells and act as a signal transduction channel between cells. They encompass different biomolecules, such as proteins, nucleic acids and lipids, thus rendering them naturally as an attractive drug delivery vehicle. Like the other advanced drug delivery systems, such as polymeric nanoparticles and liposomes to encapsulate drug substances, exosomes also gained much attention in enhancing therapeutic activity. Exosomes present many advantages, such as compatibility with living tissues, low toxicity, extended blood circulation, capability to pass contents from one cell to another, non-immunogenic and special targeting of various cells, making them an excellent therapeutic carrier. Exosome-based molecules for drug delivery are still in the early stages of research and clinical trials. The problems and clinical transition issues related to exosome-based drugs need to be overcome using advanced tools for better understanding and systemic evaluation of exosomes. In this current review, we summarize the most up-to-date knowledge about the complex biological journey of exosomes from biogenesis and secretion, isolation techniques, characterization, loading methods, pharmaceutical and therapeutic applications, challenges and future perspectives of exosomes.

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Optical fiber amplifier and thermometer assisted point-of-care biosensor for detection of cancerous exosomes

Cited by 15 publications

References 30 publications

Sensor Technology for Opening New Pathways in Diagnosis and Therapeutics of Breast, Lung, Colorectal and Prostate Cancer

Sensor Technology for Opening New Pathways in Diagnosis and Therapeutics of Breast, Lung, Colorectal and Prostate Cancer

Sensor Technology for Opening New Pathways in Diagnosis and Therapeutics of Breast, Lung, Colorectal and Prostate Cancer

Exosomes as New Generation Vehicles for Drug Delivery: Biomedical Applications and Future Perspectives

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