Optical fiber sensor based on surface plasmon resonance for rapid detection of avian influenza virus subtype H6: Initial studies

179

Surface Plasmon Resonance (SPR) fiber sensor research has grown since the first demonstration over 20 year ago into a rich and diverse field with a wide range of optical fiber architectures, plasmonic coatings, and excitation and interrogation methods. Yet, the large diversity of SPR fiber sensor designs has made it difficult to understand the advantages of each approach. Here, we review SPR fiber sensor architectures, covering the latest developments from optical fiber geometries to plasmonic coatings. By developing a systematic approach to fiber-based SPR designs, we identify and discuss future research opportunities based on a performance comparison of the different approaches for sensing applications.

Section: Applicationsmentioning

confidence: 99%

Plasmonic Fiber Optic Refractometric Sensors: From Conventional Architectures to Recent Design Trends

Klantsataya

Jia

Ebendorff-Heidepriem

et al. 2016

179

“…A detection limit of 1 μg mL −1 was reported. Zhao et al [ 34 ] later applied side-polished SPR fiber sensor for influenza subtype H6 detection through a flow injection system. The detection limit was 5.14 × 10 5 EID 50 /0.1ML.…”

Section: Introductionmentioning

confidence: 99%

A Phase-Intensity Surface Plasmon Resonance Biosensor for Avian Influenza A (H5N1) Detection

Wong

Chua

Mittman

et al. 2017

In this paper, we present a phase-intensity surface plasmon resonance (SPR) biosensor and demonstrate its use for avian influenza A (H5N1) antibody biomarker detection. The sensor probes the intensity variation produced by the steep phase response at surface plasmon excitation. The prism sensor head is fixed between a pair of polarizers with a perpendicular orientation angle and a forbidden transmission path. At SPR, a steep phase change is introduced between the p- and s-polarized light, and this rotates the polarization ellipse of the transmission beam. This allows the light at resonance to be transmitted and a corresponding intensity change to be detected. Neither time-consuming interference fringe analysis nor a phase extraction process is required. In refractive index sensing experiments, the sensor resolution was determined to be 6.3 × 10−6 refractive index values (RIU). The sensor has been further applied for H5N1 antibody biomarker detection, and the sensor resolution was determined to be 193.3 ng mL−1, compared to 1 μg mL−1 and 0.5 μg mL−1, as reported in literature for influenza antibody detection using commercial Biacore systems. It represents a 517.3% and 258.7% improvement in detection limit, respectively. With the unique features of label-free, real-time, and sensitive detection, the phase-intensity SPR biosensor has promising potential applications in influenza detection.

“…In particular, a fiber-optic SPR system has been described for the analysis of avian influenza virus subtype H6 [ 66 ]. To optimize the immobilization of the self-assembled monolayers (SAM) and the subsequent antibody functionalization, the optical fiber was modified with plasma at low temperature, which rendered better results than chemical modification.…”

Section: Other Plasmonic Nanomaterial-based Strategiesmentioning

confidence: 99%

Recent Progress in Plasmonic Biosensing Schemes for Virus Detection

Mauriz

2020

The global burden of coronavirus disease 2019 (COVID-19) to public health and global economy has stressed the need for rapid and simple diagnostic methods. From this perspective, plasmonic-based biosensing can manage the threat of infectious diseases by providing timely virus monitoring. In recent years, many plasmonics’ platforms have embraced the challenge of offering on-site strategies to complement traditional diagnostic methods relying on the polymerase chain reaction (PCR) and enzyme-linked immunosorbent assays (ELISA). This review compiled recent progress on the development of novel plasmonic sensing schemes for the effective control of virus-related diseases. A special focus was set on the utilization of plasmonic nanostructures in combination with other detection formats involving colorimetric, fluorescence, luminescence, or Raman scattering enhancement. The quantification of different viruses (e.g., hepatitis virus, influenza virus, norovirus, dengue virus, Ebola virus, Zika virus) with particular attention to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was reviewed from the perspective of the biomarker and the biological receptor immobilized on the sensor chip. Technological limitations including selectivity, stability, and monitoring in biological matrices were also reviewed for different plasmonic-sensing approaches.