2005
DOI: 10.1562/2004-06-25-ra-216.1
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Optical Properties of Human Prostate at 732 nm Measured In Vivo During Motexafin Lutetium–mediated Photodynamic Therapy¶

Abstract: Characterization of the tissue light penetration in prostate photodynamic therapy (PDT) is important to plan the arrangement and weighting of light sources so that sufficient light fluence is delivered to the treatment volume. The optical properties (absorption [mu(a)], transport scattering [mu(s)'] and effective attenuation [mu(eff)] coefficients) of 13 patients with locally recurrent prostate cancer were measured in situ using interstitial isotropic detectors. Measurements were made at 732 nm before and afte… Show more

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Cited by 76 publications
(78 citation statements)
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“…While the mean reduced scattering coefficient in canine was 3.6 ± 4.8 cm −1 , 7 it was 15 ± 11 cm −1 in human at the same wavelength (732 nm). 12 The increased reduced scattering coefficient resulted in an increased effective attenuation coefficient, or a reduction of optical penetration depth, assuming the absorption coefficient remains the same. ) produced an optical kernel approximately in the middle of the range of kernel variations (solid line in Fig.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…While the mean reduced scattering coefficient in canine was 3.6 ± 4.8 cm −1 , 7 it was 15 ± 11 cm −1 in human at the same wavelength (732 nm). 12 The increased reduced scattering coefficient resulted in an increased effective attenuation coefficient, or a reduction of optical penetration depth, assuming the absorption coefficient remains the same. ) produced an optical kernel approximately in the middle of the range of kernel variations (solid line in Fig.…”
Section: Resultsmentioning
confidence: 99%
“…We have previously shown that the human prostate has an inhomogeneous light-opacity distribution in vivo, which calls into question some of these assumptions. 12,13 A number of optimization algorithms used in brachytherapy are of interest for prostate photodynamic therapy. The most common ones are simulated annealing algorithms [14][15][16] and genetic algorithms.…”
Section: Introductionmentioning
confidence: 99%
“…Many studies have been conducted to determine the in vivo optical properties of human prostate. [77][78][79] These light fluence measurements show that the optical properties of the prostate vary substantially within a prostate gland as well as among separate prostate glands. The optical properties of prostate tissue may also vary over time during a PDT procedure.…”
Section: Iiia Light Dosimetry With Real-time Feedbackmentioning
confidence: 82%
“…To implement this model in our clinical protocol, we have developed a computer-controlled positioning system capable of moving an isotropic point source and an isotropic detector independently along parallel catheters in the prostate [22]. As a result, fluence rates can be measured at a variety of distances from the point source, and the resulting profile can be used to determine the prostate optical properties.…”
Section: Interstitial Pdt Dosimetry In Vivo Characterization Of Tissumentioning
confidence: 99%
“…However, this approach does not take into account the light scattering by tissue and usually underestimates the local light fluence rate, and consequently the fluence. Techniques have been developed to characterize the tissue optical properties and the light fluence rate in vivo [21,22]. Other optical spectroscopic methods [23,24] have been developed to characterize tissue absorption and scattering spectra, which in term provide information about tissue oxygenation and drug concentration.…”
Section: Introductionmentioning
confidence: 99%