Optically activatable photosynthetic bacteria-based highly tumor specific immunotheranostics

Yang, Xi; Komatsu, Satoru; Reghu, Sheethal; Miyako, Eijiro

doi:10.1016/j.nantod.2021.101100

Cited by 22 publications

(24 citation statements)

References 56 publications

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“…The light conversion properties of natural PSB are able to be exploited for cancer treatment. Yang et al (2021 ) developed tumor-targeted optical immunotheranostics by applying NIR activatable non-pathogenic purple photosynthetic bacteria (PPSB) for PDT and PTT, together with photoacoustic imaging. Living PPSB have been used for cancer theranostics thanks to their multifunctionality and biocompatibility, using bio-optical-window first and second NIR light.…”

Section: Applications Of Bacteria-mediated Strategies In Cancer Therapymentioning

confidence: 99%

Recent advances in bacteria-mediated cancer therapy

Liang

Wang

Shao

et al. 2022

Front. Bioeng. Biotechnol.

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Cancer is among the leading cause of deaths worldwide. Although conventional therapies have been applied in the fight against the cancer, the poor oxygen, low extracellular pH, and high interstitial fluid pressure of the tumor microenvironment mean that these treatments fail to completely eradicate cancer cells. Recently, bacteria have increasingly been considered to be a promising platform for cancer therapy thanks to their many unique properties, such as specific tumor-targeting ability, high motility, immunogenicity, and their use as gene or drug carriers. Several types of bacteria have already been used for solid and metastatic tumor therapies, with promising results. With the development of synthetic biology, engineered bacteria have been endowed with the controllable expression of therapeutic proteins. Meanwhile, nanomaterials have been widely used to modify bacteria for targeted drug delivery, photothermal therapy, magnetothermal therapy, and photodynamic therapy, while promoting the antitumor efficiency of synergistic cancer therapies. This review will provide a brief introduction to the foundation of bacterial biotherapy. We begin by summarizing the recent advances in the use of many different types of bacteria in multiple targeted tumor therapies. We will then discuss the future prospects of bacteria-mediated cancer therapies.

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Section: Applications Of Bacteria-mediated Strategies In Cancer Therapymentioning

confidence: 99%

Recent advances in bacteria-mediated cancer therapy

Liang

Wang

Shao

et al. 2022

Front. Bioeng. Biotechnol.

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“…Under near infrared light induction, the functionalized bacteria showed superior antitumor effect by laser-driven photothermal conversion and the excess TNF-a expression with the assistance of macrophages (105). Similarly, Yang et al apply non-pathogenic natural purplep synthetic bacteria Rhodopseudomonas palustris in cancer theranostics without complicated chemical functionalization and genetic manipulation, which are blessed with tumor-targeting abilities, excellent heat and ROS production, resulting in drastic tumor elimination (106).…”

Section: Combined With Photodynamic Therapy and Photothermal Therapymentioning

confidence: 99%

Current Status and Future Directions of Bacteria-Based Immunotherapy

Tang

Xian

et al. 2022

Front. Immunol.

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With the in-depth understanding of the anti-cancer immunity, immunotherapy has become a promising cancer treatment after surgery, radiotherapy, and chemotherapy. As natural immunogenicity substances, some bacteria can preferentially colonize and proliferate inside tumor tissues to interact with the host and exert anti-tumor effect. However, further research is hampered by the infection-associated toxicity and their unpredictable behaviors in vivo. Due to modern advances in genetic engineering, synthetic biology, and material science, modifying bacteria to minimize the toxicity and constructing a bacteria-based immunotherapy platform has become a hotspot in recent research. This review will cover the inherent advantages of unedited bacteria, highlight how bacteria can be engineered to provide greater tumor-targeting properties, enhanced immune-modulation effect, and improved safety. Successful applications of engineered bacteria in cancer immunotherapy or as part of the combination therapy are discussed as well as the bacteria based immunotherapy in different cancer types. In the end, we highlight the future directions and potential opportunities of this emerging field.

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“…The combination of functional nanoparticles and bacterial therapy might be a potentially transformative approach for highly tumor-specific immunostimulatory regulation. 16,21 Currently, the major challenges are to explore simpler nanofunctionalizations with nonpathogenic natural bacteria and emerging nanomicrobial technologies to effectively control immunological activities for biomedical treatments.…”

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confidence: 99%

“…Nanotechnological approaches are promising for improving the performance and synergistic effects of bacterial therapy. − In particular, nanotechnological approach-dependent photothermal conversion can significantly enhance the potential of bacterial cancer therapy. − For instance, Chen et al reported the chemical cross-linking of the external surface of the bacterial membrane of S. typhimurium with indocyanine green (ICG)-loaded nanoparticles as a photothermal agent for cancer hyperthermia . However, conventional nanotechnological approaches continue to use genetic manipulation for attenuating toxicity and improving the efficacy of bacteria.…”

mentioning

confidence: 99%

“…However, the tumor targeting potential of nanoparticles is insufficient for the desired antitumor efficacies using immune cells because enhanced permeation and retention effects and biomarker-dependent ligand–receptor interactions play dominant roles in the efficacy of immunotherapy using ordinary nanoparticle technologies. The combination of functional nanoparticles and bacterial therapy might be a potentially transformative approach for highly tumor-specific immunostimulatory regulation. , Currently, the major challenges are to explore simpler nanofunctionalizations with nonpathogenic natural bacteria and emerging nanomicrobial technologies to effectively control immunological activities for biomedical treatments.…”

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confidence: 99%

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Nanoengineered Bifidobacterium bifidum with Optical Activity for Photothermal Cancer Immunotheranostics

Reghu

Miyako

2022

Nano Lett.

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There is substantial interest regarding the understanding and designing of nanoengineered bacteria to combat various fatal diseases. Here, we report the nanoengineering of Bifidobacterium bifidum using Cremophor EL to encapsulate organic dye molecules by simple incubation and washing processes while maintaining the bacterial morphology and viability. The prepared functional bacteria exhibit characteristics such as optical absorbance, unique fluorescence, powerful photothermal conversion, low toxicity, excellent tumor targeting, and anticancer efficacy. They also displayed significant in vivo fluorescent expression in implanted colorectal cancerous tumors. Moreover, the powerful photothermal conversion of the functional bacteria could be spatiotemporally evoked by biologically penetrable near-infrared laser for effective tumor regression in mice, with the help of immunological responses. Our study demonstrates that a nanoengineering approach can provide the strong physicochemical traits and attenuation of living bacterial cells for cancer immunotheranostics.

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Optically activatable photosynthetic bacteria-based highly tumor specific immunotheranostics

Cited by 22 publications

References 56 publications

Recent advances in bacteria-mediated cancer therapy

Recent advances in bacteria-mediated cancer therapy

Current Status and Future Directions of Bacteria-Based Immunotherapy

Nanoengineered Bifidobacterium bifidum with Optical Activity for Photothermal Cancer Immunotheranostics

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