Optically activated and interrogated plasmonic hydrogels for applications in wound healing

Milanesi, Alessio; Magni, Giada; Centi, Sonia; Schifino, Gioacchino; Aluigi, Annalisa; Khlebtsov, Boris N.; Cavigli, Lucia; Barucci, Andrea; Khlebtsov, Nikolai G.; Ratto, Fulvio; Rossi, Francesca; Pini, Roberto

doi:10.1002/jbio.202000135

Cited by 18 publications

(12 citation statements)

References 103 publications

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“…For example, Au NR–PVA nanofibers can yield a stable flexible self-supporting membrane with good SERS performances and enhanced optical nonlinearity. , Au NR–PNIPAM hydrogel composites fabricated through electrospinning and solidification treatment show rapid thermal/light responses and high structural integrity . (Au core)@(Ag shell) NR assemblies held in porous chitosan–PVA scaffolds present excellent photothermal conversion performances, potentially useful in tissue engineering and wound healing …”

Section: Assembly and Organization Of Gold Nanorodsmentioning

confidence: 99%

“…656 (Au core)@(Ag shell) NR assemblies held in porous chitosan− PVA scaffolds present excellent photothermal conversion performances, potentially useful in tissue engineering and wound healing. 657 Copolymers can template the assembly of Au NRs through microphase separation. When Au NRs are incorporated into copolymer matrixes, Au NRs are preferentially confined in the microphase domains of the copolymer module, as a result of the minimization of conformational entropy loss.…”

Section: Template-assisted Assemblymentioning

confidence: 99%

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Gold Nanorods: The Most Versatile Plasmonic Nanoparticles

et al. 2021

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Gold nanorods (NRs), pseudo-one-dimensional rod-shaped nanoparticles (NPs), have become one of the burgeoning materials in the recent years due to their anisotropic shape and adjustable plasmonic properties. With the continuous improvement in synthetic methods, a variety of materials have been attached around Au NRs to achieve unexpected or improved plasmonic properties and explore state-of-the-art technologies. In this review, we comprehensively summarize the latest progress on Au NRs, the most versatile anisotropic plasmonic NPs. We present a representative overview of the advances in the synthetic strategies and outline an extensive catalogue of Au-NR-based heterostructures with tailored architectures and special functionalities. The bottom-up assembly of Au NRs into preprogrammed metastructures is then discussed, as well as the design principles. We also provide a systematic elucidation of the different plasmonic properties associated with the Au-NR-based structures, followed by a discussion of the promising applications of Au NRs in various fields. We finally discuss the future research directions and challenges of Au NRs.

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Section: Assembly and Organization Of Gold Nanorodsmentioning

confidence: 99%

Section: Template-assisted Assemblymentioning

confidence: 99%

Gold Nanorods: The Most Versatile Plasmonic Nanoparticles

et al. 2021

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“…In brief, particles were transferred at a nominal concentration of 200 μM Au in a solution containing 20 mM cetrimonium chloride (CTAC) and supplemented with 400 μM AgNO3 and 1.6 mM ascorbic acid. This molar ratio of Ag:Au around 2:1 was intended to convey a blue shift of the longitudinal modes of the gold nanorods exceeding 200 nm . After 2 h at 70 °C, particles were brought to a concentration of 1.6 mM Au in a 100 mM acetate buffer pH 5.0 containing 500 μM CTAC, 0.005% (w/w) polysorbate 20 and 50 μM mPEG-SH, in order to obtain an amphiphilic termination and delay the onset of oxidative degradation of the silver shell.…”

Section: Methodsmentioning

confidence: 99%

Photomobile Polymer–Piezoelectric Composite for Enhanced Actuation and Energy Generation

Sagnelli,

D’Avino,

Rippa

et al. 2023

ACS Appl. Opt. Mater.

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In this study, we present an innovative approach to increase the quantum yield and wavelength sensitivity of photomobile polymer (PMP) films based on azobenzene by doping the polymer matrix with noble metal nanoparticles. These doped PMP films showed faster and more significant bending under both UV as well as visible and near-infrared light regardless of whether it was coherent, incoherent, polarized, or unpolarized irradiation, expanding the potential of PMP-based actuators. To illustrate their practical implications, we created a proof-of-concept model of power generation by coupling it to flexible piezoelectric materials under simulated sunlight. This model has been tested under real operating conditions, thus demonstrating the possibility of generating electricity with variable light exposure. Additionally, our synthetic protocol is solvent-free, which is another benefit of environmental relevance. Our research lays the groundwork for the development of sunlight-sensitive devices, such as photomechanical actuators and advanced photovoltaic modules, which may break ground in the thriving field of smart materials. We are confident that the presented findings will contribute to the ongoing discourse in the field and inspire additional advances in renewable energy applications.

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“…In particular, polysaccharides as hyaluronan and chitosan and their derivatives are suitable for laser bonding, mainly for their high affinity to the biological matrix, biodegradability, non-toxicity and low cost. Moreover, chitosan is characterized by hemostatic, wound healing-promoting activity and naturally tends to form films with high mechanical strength and good elasticity [ 15 , 16 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Characterization and Ex Vivo Application of Indocyanine Green Chitosan Patches in Dura Mater Laser Bonding

et al. 2021

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Dura mater repair represents a final and crucial step in neurosurgery: an inadequate dural reconstruction determines dreadful consequences that significantly increase morbidity and mortality rates. Different dural substitutes have been used with suboptimal results. To overcome this issue, in previous studies, we proposed a laser-based approach to the bonding of porcine dura mater, evidencing the feasibility of the laser-assisted procedure. In this work, we present the optimization of this approach in ex vivo experiments performed on porcine dura mater. An 810-nm continuous-wave AlGaAs (Aluminium Gallium Arsenide) diode laser was used for welding Indocyanine Green-loaded patches (ICG patches) to the dura. The ICG-loaded patches were fabricated using chitosan, a resistant, pliable and stable in the physiological environment biopolymer; moreover, their absorption peak was very close to the laser emission wavelength. Histology, thermal imaging and leak pressure tests were used to evaluate the bonding effect. We demonstrated that the application of 3 watts (W), pulsed mode (Ton 30 ms, Toff 3.5 ms) laser light induces optimal welding of the ICG patch to the dura mater, ensuring an average fluid leakage pressure of 216 ± 105 mmHg, falling within the range of physiological parameters. This study demonstrated that the thermal effect is limited and spatially confined and that the laser bonding procedure can be used to close the dura mater. Our results showed the effectiveness of this approach and encourage further experiments in in vivo models.

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Optically activated and interrogated plasmonic hydrogels for applications in wound healing

Cited by 18 publications

References 103 publications

Gold Nanorods: The Most Versatile Plasmonic Nanoparticles

Gold Nanorods: The Most Versatile Plasmonic Nanoparticles

Photomobile Polymer–Piezoelectric Composite for Enhanced Actuation and Energy Generation

Characterization and Ex Vivo Application of Indocyanine Green Chitosan Patches in Dura Mater Laser Bonding

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