Optically Specific Detection of D- and L-Lactic Acids by a Flow-Injection Dual Biosensor System with On-line Microdialysis Sampling

Nanjo, Yoko; Yano, Takayuki; Hayashi, Ryutaro; Yao, Takeshi

doi:10.2116/analsci.22.1135

Cited by 14 publications

(5 citation statements)

References 19 publications

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“…The biosensor consisted of a triple enzyme electrode that selectively detected glucose, l -lactate, and pyruvate without significant cross-reactivity [79]. Similar flow injection-based online systems were described by the same group for l -glutamate, acetylcholine, and dopamine [80] and d -/ l -lactic acid [81]. …”

Section: Microdialysis Coupled To Biosensorsmentioning

confidence: 99%

Recent trends in microdialysis sampling integrated with conventional and microanalytical systems for monitoring biological events: A review

Nandi

Lunte

2009

Analytica Chimica Acta

199

150

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Microdialysis (MD) is a sampling technique that can be employed to monitor biological events both in vivo and in vitro. When it is coupled to an analytical system, microdialysis can provide near realtime information on the time-dependent concentration changes of analytes in the extracellular space or other aqueous environments. Online systems for the analysis of microdialysis samples enable fast, selective and sensitive analysis while preserving the temporal information. Analytical methods employed for online analysis include liquid chromatography (LC), capillary (CE) and microchip electrophoresis and flow-through biosensor devices. This review article provides an overview of microdialysis sampling and online analysis systems with emphasis on in vivo analysis. Factors that affect the frequency of analysis and, hence, the temporal resolution of these systems are also discussed.

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Section: Microdialysis Coupled To Biosensorsmentioning

confidence: 99%

Recent trends in microdialysis sampling integrated with conventional and microanalytical systems for monitoring biological events: A review

Nandi

Lunte

2009

Analytica Chimica Acta

199

150

View full text Add to dashboard Cite

show abstract

“…Yao et al also reported an online system employing a triple -enzyme electrode for the detection of glucose, l -lactate, and pyruvate [69] . Similar fl ow injectionbased online systems were described by the same group for l -glutamate, acetylcholine, and dopamine [72] and d -/ l -lactic acid [73] .…”

Section: Non -Separation -Based Methods Of Analysismentioning

confidence: 93%

Analytical Considerations for Microdialysis Sampling

Nandi

Kuhnline

Lunte

2011

Applications of Microdialysis in Pharmaceutical Science

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“…Liu et al [ 23 ] separated and measured L-lactic acid and D-lactic acid in kimchi and concluded that L-lactic acid was dominant in kimchi, and the content of L-lactic acid gradually increased during the fermentation process, while the content of D-lactic acid first increased and then decreased. Nanjo et al [ 24 ] developed an enzyme sensor system for the simultaneous determination of D-lactic acid and L-lactic acid in alcoholic beverages. The olfactory threshold and aroma characteristics of chiral flavor compounds may vary depending on the stereoisomers considered, so lactic acid isomers must be isolated to obtain an accurate assessment of their flavor characteristics.…”

Section: Introductionmentioning

confidence: 99%

Distribution and Quantification of Lactic Acid Enantiomers in Baijiu

Qiu

Dai

et al. 2022

Foods

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Enantiomers of lactic acid were investigated in Baijiu, including soy sauce aroma-type Baijiu (SSB), strong aroma-type Baijiu (STB), and light aroma-type Baijiu (LTB), via high-performance liquid chromatography with a chiral separation column. The natural concentration and enantiomeric distribution of lactic acid were studied, and their contribution to the flavor of Chinese Baijiu was evaluated based on recognition threshold. The results showed that there were significant differences in the content of lactic acid and the ratio of enantiomeric isomers among different aroma types and storage year. In SSB, the concentrations of D-lactic acid and L-lactic acid were higher, with the highest concentrations of 1985.58 ± 11.34 mg/L and 975.31 ± 14.03 mg/L, respectively. In STB, the highest concentrations of D-lactic acid and L-lactic acid were 1048.00 ± 11.46 mg/L and 939.83 ± 0.23 mg/L, respectively. In LTB, the highest concentrations of D-lactic acid and L-lactic acid were 760.90 ± 9.45 mg/L and 558.33 ± 3.06 mg/L, respectively. The average D/L enantiomeric ratios were 78:22 ± 16.16 and 80:20 ± 9.72 in the Commercial Baijiu products of SSB and STB, respectively. The average D/L enantiomeric ratio in LTB was 90:10 ± 6.08. D-lactic acid in JSHS vintage Baijiu showed a wave variation with aging, while L-lactic acid gradually increased during aging, and the average D/L enantiomeric ratio was 76:24 ± 4.26. The concentration of D-lactic acid in XJCT vintage Baijiu also showed a wave variation with aging, and the concentration of L-lactic acid tended to be stable during aging, with an average D/L enantiomeric ratio of 88:12 ± 2.80. The content of the two configurations of lactic acid in the LZLJ vintage Baijiu showed a decreasing trend during aging, with an average D/L enantiomeric ratio of 60:40 ± 11.99. The recognition threshold of D-lactic acid in 46% ethanol solution was 194.18 mg/L with sour taste; while the L-lactic acid was 98.19 mg/L with sour taste. The recognition threshold of L-lactic acid was about half that of D-lactic acid, indicating that L-lactic acid has a stronger sour taste. The taste activity values (TAVs) of D-lactic acid and L-lactic acid were greater than 1 in most of the Baijiu samples, and the TAV of D-lactic acid was greater than that of L-lactic acid. The study showed that the lactic acid enantiomers contributed to the taste perception of Baijiu in most of the samples, and D-lactic acid contributed more to the Baijiu taste than L-lactic acid.

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Optically Specific Detection of D- and L-Lactic Acids by a Flow-Injection Dual Biosensor System with On-line Microdialysis Sampling

Cited by 14 publications

References 19 publications

Recent trends in microdialysis sampling integrated with conventional and microanalytical systems for monitoring biological events: A review

Recent trends in microdialysis sampling integrated with conventional and microanalytical systems for monitoring biological events: A review

Analytical Considerations for Microdialysis Sampling

Distribution and Quantification of Lactic Acid Enantiomers in Baijiu

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