Ancient villages are precious architectural treasures that have been protected from fire hazards for centuries through traditional fire prevention strategies. However, research on traditional fire response strategies is limited, with existing studies mainly focusing on climate response strategies, conservation, and renewal. No prior research has revealed the quantitative fire response strategies used for ancient buildings. This paper takes the first ancient village in western Hunan, High-Chair village, as an example, and it (1) assesses the fire risk of High-Chair village; (2) determines the traditional fire response strategies of the ancient village, including fire prevention culture, residential layout, wall forms, and fire resistant materials; and (3) uses CFD simulation to reveal and verify the science and rationale of the traditional patio layout and hill wall forms. The study suggests utilizing CFD simulation to quantitatively assess and validate fire response strategies. Such knowledge of fire prevention can provide fire mitigation solutions for rural construction.