Optimal design of batch and simulated moving bed chromatographic separation processes

Jupke, Andreas; Epping, Achim; Schmidt–Traub, H.

doi:10.1016/s0021-9673(01)01311-5

Cited by 84 publications

(61 citation statements)

References 22 publications

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“…However, in order to fully take advantage of this principle, a large number of operational parameters (e.g., flowrates, switching time and column configuration) need to be properly adjusted. 2 For mathematical modeling and computer simulation of SMB systems, several different models are used, including true moving bed (TMB) model, [3][4] continuous moving bed (CMB) model for linear systems [5][6] and simulated moving bed (SMB) model 1,[7][8] . However, the quality of the solution of the TMB or CMB model is only sufficient for a restricted range of applications.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, the combined models lead to a nonlinear and coupled partial differential algebraic equation (PDAE) system which is often solved, after discretization of spatial derivatives, by ODE or DAE (differential algebraic equation) time-integrators (e.g., DASSL 10 ) in the framework of the method of lines (MOL). [4][5]8,[11][12][13] The MOL converts the distributed dynamic system into a large system of ODEs or DAEs, which often requires a long computational time and may give rise to substantial discretization error. 14 A conservation element and solution element method, [14][15][16][17] CE/SE method for short, has been proposed to accurately and effectively solve the distributed dynamic system (or PDEs).…”

Section: Introductionmentioning

confidence: 99%

“…The features i)-iii) and vi) render this SMB process non-standard, thus a model is developed to investigate different aspects of this SMB operation and to optimize the process. A nonlinear and nonequilibrium SMB model 1,[7][8] is developed in this study and the CE/SE method 14,17 is employed to ensure fast and accurate calculation.…”

Section: Introductionmentioning

confidence: 99%

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Optimization of a Six-Zone Simulated-Moving-Bed Chromatographic Process

Lim

Jørgensen

2007

Ind. Eng. Chem. Res.

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Using strong cation exchange simulated moving bed (SMB) chromatography, a nitrogen-phosphate-potassium (NPK) fertilizer is produced in a cost-effective manner. The SMB process operated in a non-traditional way is divided into production and regeneration sections for exclusion of undesirable ions, and composed of six zones including two wash-water zones. This paper addresses modeling, simulation and optimization studies on this ionexchange SMB process, based upon experimental data obtained both from a pilot plant and an industrial plant. This study aims to optimize the SMB process in terms of i) maximization of productivity in the production section and ii) minimization of wash-water consumption, thereby resulting in i) increasing the profit and ii) reducing the overall operating cost in the downstream processing, respectively. The two objectives are sequentially treated within the framework of a multi-level optimization procedure (MLOP) which includes two pre-optimization levels, a productivity maximization level and a desorbent (or wash-water) consumption minimization level. In this optimization study, it is demonstrated that wash-water consumption can be reduced by 5 % at a 5% higher productivity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Optimization of a Six-Zone Simulated-Moving-Bed Chromatographic Process

Lim

Jørgensen

2007

Ind. Eng. Chem. Res.

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“…The combination of these versatile chiral HPLC columns and chiral detectors (ORD and CD) can be used to analyze/isolate many novel enantiomeric compounds (Aboul-Enein et al, 2000;Feng & May, 2001). Recently, isolation on a milligram or gram level has been developed for pure enantiomeric compounds using the simulated moving bed (SMB) technique (Jupke et al, 2002). Additionally, the enantioseparation cost of SMB and conventional batch separation depends largely on the cost of the mobile phase (Pynnonen, 1998, Jupke et al, 2002.…”

mentioning

confidence: 99%

“…Recently, isolation on a milligram or gram level has been developed for pure enantiomeric compounds using the simulated moving bed (SMB) technique (Jupke et al, 2002). Additionally, the enantioseparation cost of SMB and conventional batch separation depends largely on the cost of the mobile phase (Pynnonen, 1998, Jupke et al, 2002. A polar mobile phase of methanol-water or ethanol-water has been widely thought to be the most economical way for preparative enantioseparation under the reverse phase mode.…”

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confidence: 99%

Comparative Enantioseparation of Monoterpenes by HPLC on Three Kinds of Chiral Stationary Phases with an On-Line Optical Rotatory Dispersion under Reverse Phase Mode.

Mookdasanit

Tamura

2002

FSTR

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HPLC enantioseparation of chiral monoterpenes was studied using amylose (AD-H), cellulose (OD-H) and ␤-cyclodextrin (CD-Ph), phenyl carbamate derivatives as chiral stationary phases (CSPs). The contributions of various functional groups of the chiral monoterpenes in capacity factor (k), separation factor (␣) and resolution factor (Rs) were investigated. AD-H column clearly showed the chiral recognition in 7 chemicals from a total of 9 analytes and especially for linalool, while the CD-Ph column could achieve efficient enantioseparation on carvone. The enantioseparation mechanism between the analytes and the CSPs is discussed. Chiral HPLC system coupled with ORD detector could be applied to isolate and directly determine the configuration of (3S)-(+)-linalool, which is not commercially available. Moreover, 100% enantiomeric excess of the isolated (3S)-(+)-linalool was observed from the SPME-GCMS result. Additionally, enantioseparation of (3S)-(+)-linalool by preparative HPLC system offered a 500-fold higher sample loading capacity than that of GC.

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Adsorption, Liquid Separation

Gembicki¹,

Oroskar²,

Johnson³

2002

Kirk-Othmer Encyclopedia of Chemical Technology

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Nearly every chemical manufacturing operation requires the use of separation processes to recover and purify the desired product. Liquid‐phase adsorption has long been used for the removal of contaminants present at low concentrations in process streams such as in deodorization of water, decolorization of sugar, and ion exchange of fermentation broth. Liquid‐phase simulated moving bed (SMB) processes are being increasingly used for bulk separation of a whole range of molecules whose molecular properties are very similar. Examples are p ‐xylene from C 8 aromatics, normal paraffins from iso‐paraffins, fructose from glucose, and chiral molecules in the pharmaceutical industry. When it comes to the separation of close boiling molecules, SMB processes generally provide a better alternative to other conventional means of separation from both operating and capital costs point of view. This article reviews the application of liquid‐phase adsorption processes in the hydrocarbon, industrial chemicals, food, and pharmaceutical industry. Special emphasis is given to the class of processes referred to as SMB processes including fundamental SMB principles , and the general applicability and guidelines for SMB design. The paper also illustrates several examples of SMB applications in the petrochemical industry and its recent growth in the pharmaceutical and biotech industry.

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Optimal design of batch and simulated moving bed chromatographic separation processes

Cited by 84 publications

References 22 publications

Optimization of a Six-Zone Simulated-Moving-Bed Chromatographic Process

Optimization of a Six-Zone Simulated-Moving-Bed Chromatographic Process

Comparative Enantioseparation of Monoterpenes by HPLC on Three Kinds of Chiral Stationary Phases with an On-Line Optical Rotatory Dispersion under Reverse Phase Mode.

Adsorption, Liquid Separation

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