The problem of voltage control and reactive power management plays a crucial role on power system's operations. Particularly, detecting the most effective control actions to reduce the system loss and enhance the voltage profile is of major interest. This paper deals with system voltage inadequacy detection. To address this problem, artificial immune system is employed considering its negative selection mechanism. Its purpose is to monitor system operation data entry and check if the voltage level is within its operating values. In this sense, the user may define the range of control, so the proposed methodology may be useful for normal and emergency operating conditions. Corrective actions are undertaken if necessary. The IEEE 34 nodes distribution system is used to test the proposed methodology.