This paper presents an Enhanced Marine Predators Algorithm (EMPA) for simultaneous optimal distribution system reconfigurations (DSRs) and distributed generations (DGs) addition. The proposed EMPA recognizes the changes opportunity in environmental and climatic conditions. The EMPA handles a multi-objective model to minimize the power losses and enhance the voltage stability index (VSI) at different loading levels. The proposed EMPA is performed on IEEE 33-bus and large-scale 137-bus distribution systems (DSs) where three distinct loading conditions are beheld through light, nominal and heavy levels. For the 33-bus DS, the proposed EMPA successfully reduces the cumulative losses by 72.4 % compared to 70.36 % for MPA for the three-loading levels simultaneously. As a result, significant voltage improvement is achieved for heavy, nominal and light loadings to be 95.05, 97, 98.3%, respectively. For the 137-bus DS, it successfully minimizes the losses of 81.16 % under small standard deviation 4.76 %. Also, the 83-bus test system is considered for fair comparative between the proposed and previous techniques. The simulation outputs revealed significant improvements in the standard MPA and demonstrated the superiority and effectiveness of the proposed EMPA compared to other reported results by recent algorithms for DSRs associated with DGs integration.