Optimal Power for Microwave Slotted Probes in Ablating Different Hepatocellular Carcinoma Sizes

Ashour, Amira S.; Asran, Menna; Fotiadis, Dimitrios I.

doi:10.1016/j.compbiomed.2020.104101

Cited by 14 publications

(9 citation statements)

References 13 publications

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“…High-frequency electromagnetic energy (commercially available at 915 MHz or 2.45 GHz) generated by a microwave power generator is transferred through a coaxial cable as an antenna into surrounding tissues to cause a rise in temperature to 60 • C or above, which leads to protein denaturation and coagulative necrosis [11][12][13][14][15][16][17]. It is widely accepted that the heat energy is due to the agitation of polar molecules (i.e., water molecules) in the tissue caused by the high-frequency electromagnetic energy [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

A review of antenna designs for percutaneous microwave ablation

et al. 2021

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Microwave (MW) antenna is a key element in microwave ablation (MWA) treatments as the means that energy is delivered in a focused manner to the tumor and its surrounding area. The energy delivered results in a rise in temperature to a lethal level, resulting in cell death in the ablation zone. The delivery of energy and hence the success of MWA is closely dependent on the structure of the antennas. Therefore, three design criteria, such as expected ablation zone pattern, efficiency of energy delivery, and minimization of the diameter of the antennas have been the focus along the evolution of the MW antenna. To further improve the performance of MWA in the treatment of various tumors through inventing novel antennas, this article reviews the state-of-the-art and summarizes the development of MW antenna designs regarding the three design criteria.

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Section: Introductionmentioning

confidence: 99%

A review of antenna designs for percutaneous microwave ablation

et al. 2021

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“…Although they impose less invasiveness and toxic effects on patients in comparison with conventional surgery, chemotherapy, and radiotherapy, current local hyperthermia can cause a series of side effects, , including thermal damage to the normal tissues adjacent to ablated tumors because both normal and cancerous masses share comparable heating efficacies. As restricted by the limited ablation zone of current local hyperthermia, they are only able to ablate solid tumors up to ∼5 cm across at a comparable therapeutic efficacy to surgery . Additionally, it has been indicated that local hyperthermia not only releases large amounts of tumor-associated antigens (TAAs) but also provides a bridging time window to collectively provoke specific antitumor immunity by activating the host’s immune system. − However, due to the limited immunogenicity of most TAAs and the immunosuppressive features of both ablated and untreated metastatic tumors, current local hyperthermia cannot elicit sufficient specific antitumor immunity to prevent local recurrence and distant metastasis .…”

Section: Introductionmentioning

confidence: 99%

“…As restricted by the limited ablation zone of current local hyperthermia, they are only able to ablate solid tumors up to ∼5 cm across at a comparable therapeutic efficacy to surgery. 18 Additionally, it has been indicated that local hyperthermia not only releases large amounts of tumor-associated antigens (TAAs) but also provides a bridging time window to collectively provoke specific antitumor immunity by activating the host's immune system. 19−22 However, due to the limited immunogenicity of most TAAs and the immunosuppressive features of both ablated and untreated metastatic tumors, current local hyperthermia cannot elicit sufficient specific antitumor immunity to prevent local recurrence and distant metastasis.…”

Section: Introductionmentioning

confidence: 99%

Rational Design of Biomaterials to Potentiate Cancer Thermal Therapy

Zhu

Wang

et al. 2023

Chem. Rev.

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Cancer thermal therapy, also known as hyperthermia therapy, has long been exploited to eradicate mass lesions that are now defined as cancer. With the development of corresponding technologies and equipment, local hyperthermia therapies such as radiofrequency ablation, microwave ablation, and high-intensity focused ultrasound, have has been validated to effectively ablate tumors in modern clinical practice. However, they still face many shortcomings, including nonspecific damages to adjacent normal tissues and incomplete ablation particularly for large tumors, restricting their wide clinical usage. Attributed to their versatile physiochemical properties, biomaterials have been specially designed to potentiate local hyperthermia treatments according to their unique working principles. Meanwhile, biomaterial-based delivery systems are able to bridge hyperthermia therapies with other types of treatment strategies such as chemotherapy, radiotherapy and immunotherapy. Therefore, in this review, we discuss recent progress in the development of functional biomaterials to reinforce local hyperthermia by functioning as thermal sensitizers to endow more efficient tumor-localized thermal ablation and/or as delivery vehicles to synergize with other therapeutic modalities for combined cancer treatments. Thereafter, we provide a critical perspective on the further development of biomaterial-assisted local hyperthermia toward clinical applications.

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“…Ashour et al 28 used FEM to investigate the relationship between power dissipation, exposure duration, and subsequent temperature at three microwave frequencies: 433 MHz, 915 MHz, and 2.45 GHz inside a human liver with hepatocellular carcinoma. The authors found that a tumor with a diameter of 24, 28, 36, and 39 mm could be completely ablated using the single slot with shifted 1t (SSST) probe with input power of 20 W for 3, 5, 10, and for 15‐min treatment.…”

Section: Introductionmentioning

confidence: 99%

Numerical analogy of bioheat transfer and microwave cancer therapy for liver tissue

2022

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A numerical study of microwave cancer therapy for cylindrical-shaped liver tissue with an elliptical-shaped liver tumor has been carried out by this study. The time-dependent electromagnetic wave and the bio-heat transfer equations have been used as the governing equations and solved with appropriate boundary conditions using Galerkin's weighted residual scheme built-in finite element method-based COMSOL Multiphysics software. The coaxial applicator as well as the effects of different microwave input power levels (from 5 to 25 W), frequencies (from 0.7 to 5 GHz), and treatment time (from 0 to 1000 s) on hepatocellular carcinoma have been examined by this simulation and displayed graphically in terms of the microwave power dissipation, isothermal lines inside liver tissue, timedependent profiles of temperature at different locations inside the tumor, specific absorption rate (SAR), and surface average transient temperature distribution of tumor tissue. The results demonstrate that microwave input antenna power and frequency have significant impacts on the temperature distribution and SAR values of liver tissue. When the microwave input power, as well as frequency, is increased, SAR and tissue temperature values also increase but the high

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Optimal Power for Microwave Slotted Probes in Ablating Different Hepatocellular Carcinoma Sizes

Cited by 14 publications

References 13 publications

A review of antenna designs for percutaneous microwave ablation

A review of antenna designs for percutaneous microwave ablation

Rational Design of Biomaterials to Potentiate Cancer Thermal Therapy

Numerical analogy of bioheat transfer and microwave cancer therapy for liver tissue

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